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The 1st and 2nd term of International Open Laboratory

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IOL2017

The NIRS International Open Laboratory (IOL) started at the end of 2008 due to great efforts of Profs. Ohtsura Niwa and Hirohiko Tsujii, having created an environment where young researchers can engage in advanced research with the support of distinguished scientists in the world. The first term IOL consisted of three units, and Prof. Anders Brahme (Karolinska Institute, Sweden), Prof. Penny Jeggo (Sussex University, U.K.), and Prof. Tom Hei, (Columbia University, USA) paired up with selected NIRS researchers and performed active international collaborative research. Following a successful completion of the first term, the same vibrant spirit continues for the second term IOL which started in April 2011 for three years with four units. Two new distinguished scientists, Prof. Jac Nickoloff (Colorado State Univ., USA) and Prof. Marco Durante (GSI, Germany) joined us for the second term in addition to the former three professors. Collaborative publications in international journals are increasing and articles on IOL have appeared in the web sites of foreign organizations. We are hoping that NIRS IOL becomes a good model for international collaborations.

Organization (The 2nd Term of IOL)

Directors

Director : Makoto Akashi

Vice Director : Tadashi Kamada, Kazuo Sakai, Takeshi Murakami

Scientific Secretary : Ryuichi Okayasu

Chief Advisor : Hirohiko Tsujii

 

 

Secretariat

 

Shigekazu Fukuda(Head)

Takashi Fujita

Yukari Mizumura

Rie Sano

 

 
Name of Reserch Unit Unit Leader J  Unit Leader F
Space Radiation Research Unit Yukio Uchihori

Tom Hei

Professor and Vice-Chairman of Radiation Oncology
Associate Director, Center for Radiological Research
Professor of Environmental Health Sciences
Columbia University Medical Center, New York, NY USA

Radiation Response Model Unit Naruhiro Matsufuji

Anders Brahme

Professor of Medical Radiation Physics
Division of Medical Radiation Physics
Department of Oncology-Pathology
Karolinska Institute, Stockholm Sweden

Particle Therapy Molecular Target Unit
Akira Fujimori

Penny A. Jeggo 

Professor
Genome Damage and Stability Centre
University of Sussex
Brighton, UK

Jac A. Nickoloff 

Professor and Head
Environmental and Radiological Health Sciences
Colorado State University
Fort Collins, CO USA

Particle Beam Quality Research Unit Yoshiya Furusawa

Marco Durante

Professor and Head
Biophysics Department
GSI Helmholtzzentrum fur Schwerionenforschung
Darmstadt, Germany

 

 

Objectives

  1. To conduct world top level research by collaborating with distinguished professors from leading research institutes in US and Europe.
  2. To promote further internationalization at NIRS by active research collaborations with foreign scientists(e.g., To have more activities in English)

Workshops

  • NIRS IOL Second Term Final Report Meeting. January 29th 2014
  • IOL Progress Report Meeting 2013. January 22th 2013.
  • NIRS-Columbia University Joint Workshop 2012. June 12th 2012.

Poster [PDFファイル/528KB]
Program [PDFファイル/118KB]

  • The 2nd Term IOL Research Seminar in November (4 units + Distinguished Scientists organized by NIRS Open Lab.)
  • NIRS International Symposium on Radiation Life Sciences. June 12th 2011
    (organized by NIRS Open Lab. Planning Office)
  • The 6th NIRS IOL Workshop on Recent Advances in DNA Repair and Related Studies. March 24th 2010.
    (organized by Particle Radiation Molecular Biology Unit)
  • The 5th NIRS IOL Workshop on Advances in Dosimetry and Health Effects Associated with Exposure to Articles of Space Radiation Environment. January 13th 2010.
    (organized by Space Radiation Effects Research Unit)

 

The 4th NIRS IOL Workshop on Cellular and Molecular Effects of Light Ions, April 15, 2009.
(organized by Particle Therapy Model Research Unit)

The 3rd NIRS IOL workshon on February 27

Poster [PDFファイル/97KB]| Program [PDFファイル/92KB]

The 3rd NIRS IOL Workshop on Recent Development in DNA Repair Studies, February 27, 2009.
(organized by Particle Radiation Molecular Biology Unit)

The 3rd NIRS IOL workshop on February 27.2009

Poster [PDFファイル/726KB]) | Program [PDFファイル/726KB]

The 2nd NIRS IOL Workshop on Challenges in the New Frontier in Space Travel, Physics and Biology of Radiation Risk, February 12, 2009.
(organized by Space Radiation Effects Research Unit)

The 2nd NIRS IOL workshop on February 12 2009

Poster [PDFファイル/708KB] | Program [PDFファイル/40KB]MeetingReports [PDFファイル/705KB]

The 1st NIRS IOL Workshop on Innovation in the Radiation Therapy, November 17, 2008.
(organized by Particle Therapy Model Research Unit)

The 1st NIRS IOL workshop on November 17 2008

Poster [PDFファイル/1.74MB] | Program [PDFファイル/14KB]MeetingReports [PDFファイル/1.85MB]

Press Release

Press release(December 2, 2011)
NIRS and Columbia University, NY, USA have signed a "Memorandum of Understanding" for collaborative biomedical research using radiation including heavy ions produced by HIMAC at NIRS (Nov. 21, 2011)

Outcomes/Achievement/Special Remarks

    Peer-reviewed publications directly related to IOL,  ( 2011~2013 )

  1. Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A. The complexity of DNA double strand breaks is a critical factor enhancing end-resection. DNA Repair. 12(11): 936-946. 2013.
  2. Nakajima NI, Brunton H, Watanabe R, Shrikhande A, Hirayama R, Matsufuji N, Fujimori A, Murakami T, Okayasu R, Jeggo P, Shibata A. Visualisation of fÀH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage. PLoSOne 8:e70107. 2013.
  3. Shimizu N, Nakajima NI, Tsunematsu T, Ogawa I, Kawai H, Hirayama R, Fujimori A, Yamada A, Okayasu R, Ishimaru N, Takata T, Kudo Y. Selective enhancing effect of early mitotic inhibitor 1 (Emi1) depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells. J Biol Chem. 14:288(24):17238-52. 2013
  4. Fujii Y, Yurkon CR, Maeda J, Genet SC, Kubota N, Fujimori A, Mori T, Maruo K, Kato TA. Comparative study of radioresistance between feline cells and human cells. Radiat Res. 180: 70-77. 2013.
  5. Fujisawa H, Genik PC, Kitamura H, Fujimori A, Uesaka M, Kato TA. Comparison of human chordoma cell-kill for 290 MeV/n carbon ions versus 70 MeV protons in vitro. Radiat Oncol. 8: 912013. 2013.
  6. Fujii Y, Yurkon CR, Maeda J, Genet SC, Okayasu R, Kitamura H, Fujimori A, Kato TA. Influence of track directions on the biological consequences in cells irradiated with high LET heavy ions. Int J Radiat Biol. 89: 401-10. 2013.
  7. Wada, M., Suzuki, M., Liu, C. et al. Modeling the biological response of normal human cells, including repair processes, to fractionated carbon beam irradiation. J. Radiat. Res. 54: 798?807. 2013.
  8. Kodaira S, Tolochek RV, Ambrozova I, Kawashima H, Yasuda N, Kurano M, Kitamura H, Uchihori Y, Kobayashi I, Hakamada H, Suzuki A, Kartsev IS, Yarmanova EN, Nikolaev I V, Shurshakov VA. Verification of shielding effect by the water-filled materials for space radiation in the International Space Station using passive dosimeters. Advances in Space Research: (in press)
  9. Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou Y, Ikeda H, Kobayashi K, Kobayashi Y, Uchihori Y, Hei TK, Azzam EI, Murakami T. Gap Junction Communication and the Propagation of Bystander Effects Induced by Microbeam Irradiation in Human Fibroblast Cultures: The Impact of Radiation Quality. Radiat. Res. 180: 367-375. 2013.
  10. Autsavapromporn N, Suzuki M, Plante I, Liu C, Uchihori Y, Hei TK, Azzam EI, Murakami T. Participation of gap junction communication in potentially lethal damage repair and DNA damage in human fibroblasts exposed to low- or high-LET radiation. Mutat. Res. 756: 78-85. 2013.
  11. Scifoni E, Tinganelli W, Weyrather WK, Durante M, Maier A, Kramer M.
    Including oxygen enhancement ratio in ion beam treatment planning: model implementation and experimental verification. Phys Med Biol. 11:3871-95. 2013.
  12. Antonovic L, Brahme A, Furusawa Y, Toma-Dasu I. Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions. J Radiat Res.54:18-26. 2013.
  13. Ma NY, Tinganelli W, Maier A, Durante M, Kraft-Weyrather W. Influence of chronic hypoxia and radiation quality on cell survival. J Radiat Res. 54Suppl:i13-i22. 2013
  14. Fujii Y, Genet M, Roybal E, Kubota N, Okayasu R, Miyagawa K, Fujimori A, Kato T. Comparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks, Oncol. Rep. 180:70-77. 2013.
  15. Okumura K, Kinashi Y, Kubota Y, Kitajima E, Okayasu R, Ono K, Takahashi S. Relative biological effects of neutron mixed-beam irradiation for boron neutron capture therapy on cell survival and DNA double-strand breaks in cultured mammalian cells. J Radiat Res. 54:70-5. 2013.
  16. Kodaira S, Kawashima H, Kitamura H, Kurano M, Yasuda N, Ogura K, Kobayashi I, Suzuki A, Koguchi Y, Akatov Y A, Shurashakov VA, Tolochek R V, Krasheninnikova T K, Ukraintsev AD, Gureeva EA, Kuzunetsov VN, Benton E. Analysis of radiation dose variations measured by passive dosimeters on board the International Space Station during the solar quiet period (2007-2008). Radiation Measurements. 49:95-102. 2013.
  17. Shoulkamy MI, Nakano T, Ohshima M, Hirayama R, Uzawa A, Furusawa Y, Ide H. Detection of DNA-protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs Nucl Acids Res. 40:e143. 2012.
  18. Nakagawa Y, Takahashi A, Kajihara A, Yamakawa N, Imai Y, Ota I, Okamoto N, Mori E, Noda T, Furusawa Y, Kirita T, Ohnishi T. Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation. Biochem Biophys Res Comm. 423: 654-660. 2012.
  19. Genet S, Maeda J, Fujisawa H, Yurkon C, Fujii Y, Romero A, Genik P, Fujimori A, Kitamura H, Kato T. Comparison of cellular lethality in DNA repair-proficient or - deficient cell lines resulting from exposure to 70 Me V/n protons or 290 Me V/n carbon ions. Oncology Reports. 28: 1591-1596. 2012.
  20. LeSech C, Kobayashi K, Usami N, Furusawa Y, Porcel E, Lacombe S. Comment on 'Therapeutic application of metallic nanoparticles combined with particle-induced x-ray emission effect' Nanotechnology. 23:078001. 2012.
  21. LeSech C, Kobayashi K, Usami N, Furusawa Y, Porcel E, Lacombe S. Comment on "Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles" Appl Phys Lett. 100:1063. 2012.
  22. Oonishi K, Cui X, Hirakawa H, Fujimori A, Kamijo T, Yamada S, Yokosuka O, Kamada T. Different effects of carbon ion beams and X-rays on clonogenic survival an DNA repair in human pancreatic cancer stem-like cells. Radiother. Oncol. 105: 258-265. 2012.
  23. Choi V, Konishi T, Oikawa M, Cheng SH, Yu P, et.al. Triphasic low-dose response in zebrafish embryos irradiated by microbeam protons, Journal of Radiation Research. 53(3):475-481. 2012.
  24. Kodaira S, Naka S, Yasuda N, Kawashima H, Kurano M, Ota S, Ideguchi Y, Hasebe N, Ogura K. Improvement of charge resolution for high Z/fÀ particles in CR-39 nuclear track detectors by means of two-step etching technique, Nucl. Instrum. & Meth. B, 274:36-41. 2012.
  25. Antonovic L, Brahme A, Furusawa Y, Toma-Dasu I. Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions. J Radiat Res. 2012 (available on line)
  26. Sato T, Furusawa Y. Cell Survival Fraction Estimation Based on the Probability Densities of Domain and Cell Nucleus Specific Energies Using Improved Microdosimetric Kinetic Models. Radiat Res. 1781:341-356. 2012.
  27. Hirai T, Shirai H, Fujimori H, Okayasu R, Sasai K, Masutani M. Radiosensitization effect of poly(ADP-ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation. Cancer Sci. 103(6):1045-50. 2012.
  28. Tsujii H, Kamada T. A review of update clinical results of carbon ion radiotherapy. Jpn J Clin Oncol. 42(8):670-85. 2012.
  29. Okayasu, R. Repair of DNA damage induced by accelerated heavy ions-a mini review. Int. J. Cancer 130:991-1000. 2012.
  30. Fischer ES, Scrima A, Bohm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, ThomZa NH. The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation, Cell. 147(5):1024-39. 2011.
  31. Kato TA, Okayasu R, Jeggo PA, Fujimori A. ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy. IJRB 87(12):1189-1195. 2011.
  32. Kato TA, Tsuda A, Uesaka M, Fujimori A, Kamada T, Tsujii H, Okayasu R. In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs. Radiat. Oncol. 6:116 (BMC journal). 2011;
  33. Allen C, Borak TB, Tsujii H, Nickoloff JA. Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy. Mutat. Res. 711:150-157. 2011.
  34. Katsube T, Mori M, Tsuji H, Shiomi T, Shiomi N, Onoda M Differences in Sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient Human Cells. J Radiat Res. 52(4):415-24. 2011.
  35. Brahme A. Accurate Description of the Cell Survival and Biological Effect at Low and High Doses and LET's. J Radiat Res. 52(4):389-407. 2011.
  36. Ponnaiya B, Suzuki M, Tsuruoka C, Uchihori Y, Wei Y, Hei TK. Detection of chromosomal instability in bystander cells after si490-ion irradiation. Radiat Res. 176(3):280-90. 2011

List of external grant funding related to NIRS IOL from 2011 to 2013

Particle Beam Quality Research Unit(Furusawa U)

  • POFIII Helmholtz Gemainschaft, "Combined heavy ion therapy and immunotherapy" 2014-1018.

Radiation Response Model Unit(Matsufuji U)

  • Partner EU grant for Marta Lazzeroni PhD 100913: "Production Of High Quality 11C Beams For Radiation Treatment And Accurate PET-CT Dose Delivery Verification"

Particle Therapy Molecular Target Research Unit(Fujimori U)

  • Japan Society for the Promotion of Science (JSPS) KAKENHI grant # 24249067 April 2012-March 2016 PI: Ryuichi Okayasu (Akira Fujimori, Collaborator) "Basic studies on factors to improve effectiveness of radiation therapy"

Space Radiation Research Unit:(Uchihori U)

  • JSPS KAKENHI grant # 13307594, April 2013 - March 2015 PI: Teruaki Konishi, "Studies on Cellular response induced by bystander effect between normal and cancer cell lines"
  • Radiation Effect Association Fellowship Grant, April 2011 - March 2012 PI: Teruaki Konishi, "Cell cycle regulation in the low-dose radiation using the HCT116-FUCCI cells by microbeam irradiation"
  • JSPS KAKENHI grant # 25713047, April 2013 - March 2016 PI: Satoshi Kodaira "Measurement and Dosimetry of secondary particles produced in the radiotherapy fields"
  • JSPS KAKENHI grant # 24656067, April 2012 - March 2014 PI: Satoshi Kodaira "An approach of track formation mechanism in plastic nuclear track detectors with different chain length"
  • "Leading-edge Research Infrastructure Joint-use Platform Establishment Program" project funded by the Ministry of Education, Culture, Sports, Science and Technology (MEXT). Nov. 2013 - March 2015. (Research, Development and Support Center is in charge with this program)

Others

  • JSPS KAKENHI grant # 25871149 April 2013-March 2016 PI: Aya Masaoka "Studies on interacting molecular mechanisms associated with DNA double strand break repair and base excision repair"
  • Grant in aid for Cancer Research from MEXT 19-9 April 2011-Matrch 2014 PI: Mitsuko Masutani (NIRS Collaborator: Ryuichi Okayasu)"Development of radio-sensitizers effective for cancer radiation therapy"
  • JSPS KAKENHI grant # 23390301 April 2011-March 2015 PI: Akihiro Kurimasa (NIRS Collaborator: Ryuichi Okayasu)"Molecular targeting therapy aiming at cancer radio-sensitization using RNA engineering"

Special Remarks

  • Professor Marco Durante received the 2013 IBA Prize (awarded by European Physical Society) for Applied Nuclear Science and Nuclear Methods in Medicine at the 2013 International Nuclear Physics Conference in Florence, Italy, on June 7, 2013.
  • Professor Marco Durante received the Bacq and Alexander Award for his outstanding contributions to the field of radiation research at the 40th meeting of the ERRS (ERR2013) in Dublin, Ireland, on September 4, 2013.
  • The IOL progress report meeting 2012-2013 was held in January 2013. Prof. Jac Nickoloff, Colorado State Univ. and Dr. Emanuele Scifoni, GSI gave special talks in this meeting.(January 2013)
  • Prof. Tom Hei, Columbia University, USA became the president of Radiation Research Society. (October 2012)
  • IOL sponsored an international workshop at the 55th annual meeting of Japan Radiation Research Society in Sendai, Japan. IOL Distinguished Scientists, Prof. Penny Jeggo, Prof. Jac Nickoloff and Prof. Marco Durante spoke in this workshop and had great responses. (September 2012)
  • NIRS-Columbia University Joint Workshop was held at NIRS in June 2012 and many people attended. Prof. Eric Hall (keynote speaker), Prof. Tom Hei, and Prof. Clifford Chao from Columbia University as well as Prof. Marco Durante gave talks and they all were well received. Other speakers include scientists from NIRS, Columbia University and Colorado State University.
    NIRS Web News (in Japanese) (June 2012)
  • Dr. Chris Allen from Colorado State University and Dr. Walter Tinganelli were hired as appointed scientists at IOL (April 2012)
  • Dr. Ryuichi Okayasu, IOL Scientific Secretary, obtained a prestigious JSPS KAKENHI Basic Research A category grant for four years. (April 2012)
  • Press release: NIRS and Columbia University, NY, USA have signed a "Memorandum of Understanding" for collaborative biomedical research using radiation including heavy ions produced by HIMAC at NIRS. (November 2011)
  • Dr. N. Autsavapromporn, an IOL appointed scientist, obtained JSPS post-doctoral fellowship for foreign researchers for two years with Dr. Masao Suzuki, NIRS. (November 2011)
  • Prof. Penny Jeggo, Univ. of Sussex, UK was given prestigious ERRS Bacq and Alexander Award at the recent International Congress of Radiation Research meeting in Poland. (August 2011)
  • Prof. Marco Durante, GSI, Germany was chosen as President of International Association for Radiation Research (IARR) (2011)

2009

Radiological Sciences(Vol.52 No.2 inf 2009)(in Japanese) [PDFファイル/3.85MB]
Digital Booklet

 

2008

Radiological Schiences(Vol.51 No.12 in 2008) (in Japanese) [PDFファイル/3.12MB]

IOL Related Meetings

  1. The 55th Annual Meeting of The Japan Radiation Research Society, international Workshop (September 2012)
  2. The 54th Annual Meeting of The Japan Radiation Research Society, international Workshop (November 2011)
  3. NIRS-ETOILE 2nd Joint Symposium International Symposium on Heavy Ion Radiotherapy and Advanced Technology (from January 12th to 13th, 2011). 

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