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高崎量子応用研究所

プロジェクト「マイクロビーム生物研究」の業績一覧

掲載日:2019年5月7日更新
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業績一覧

原著論文

2018

Development of ultra-thin chips for immobilization of Caenorhabditis elegans in microfluidic channels during irradiation and selection ofbuffer solution to prevent dehydration. Suzuki M, Sakashita T, HattoriY, Yokota Y, Kobayashi Y, Funayama T. J Neurosci Methods. 2018 Aug1;306:32-37

2017

Region-specific irradiation system with heavy-ion microbeam for activeindividuals of Caenorhabditis elegans. Suzuki, M., Hattori, Y.,Sakashita, T., Yokota, Y., Kobayashi, Y. & Funayama, T., J. Radiat. Res.58: 881-886, 2017.

Abscopal Activation of Microglia in Embryonic Fish Brain FollowingTargeted Irradiation with Heavy-Ion Microbeam. Yasuda, T., Kamahori, M.,Nagata, K., Watanabe-Asaka, T., Suzuki, M., Funayama, T., Mitani, H. &Oda, S., Int J Mol Sci 18: 1428, 2017.

Histone deacetylase inhibitors sensitize murine B16F10 melanoma cells tocarbon ion irradiation by inducing G1 phase arrest. Saito, K., Funayama,T., Yokota, Y., Murakami, T. & Kobayashi, Y., Biol Pharm Bull 40:844-851, 2017.

An Estimation Method for Environmental Friction Based on Body DynamicModel of Caenorhabditis elegans. Soh, Z., Suzuki, M. & Tsuji, T.,J Robot Network Artificial Life, 4: 32-40, 2017.

A correlation of long term effects and radiation quality in the progenyof bystander cells after microbeam radiations: The experimental study ofradiotherapy for cancer risk mitigation. Autsavapromporn, N., Konishi,T., Liu, C., Plante, I., Funayama, T., Usami, N., Azzam, E. I. & Suzuki,M., J Phys Conf Ser 860: 012026, 2017.

2016

In vivo 3D analysis of systemic effects after local heavy-ionbeam irradiation in an animal model. Nagata, K., Hashimoto, C., Watanabe-Asaka, T., Itoh, K., Yasuda, T.,Ohta, K., Oonishi, H., Igarashi, K., Suzuki, M., Funayama, T.,Kobayashi, Y., Nishimaki, T., Katsumura, T., Oota, H., Ogawa, M., Oga,A., Ikemoto, K., Itoh, H., Kutsuna, N., Oda, S. & Mitani, H. Sci Rep 6,28691, 2016.

冷凍状態で照射した牛生レバーに誘導されるラジカル検出.菊地正博.食品照射.51,3-10 2016.

2015

ガンマ線照射により牛レバーに誘導される8-hydroxyguanineを指標とする検知法の検討.菊地正博,小林泰彦,食品照射,50(1),3-8,2015.

照射牛レバーで計測されるESRシグナル変化.菊地正博,小林泰彦,食品照射,50(1),9-12,2015.

複数ピークからなるESRスペクトルのピーク分離解析.菊地正博,永田夏樹,菰田聖一,亀谷宏美,鵜飼光子,小林泰彦,食品照射,50(1),13-19,2015.

Nitric oxide-mediated bystander signal transductions induced by heavy-ion microbeam irradiation Life Sciences in Space Research. Tomita M, Matsumoto H, Funayama T, Yokota Y, Otsuka K, Maeda M, Kobayashi Y, Life Sci Space Res, 6, 36-43, 2015.

The bystander cell-killing effect mediated by nitric oxide in normal human fibroblasts varies with irradiation dose but not with radiation quality. Yokota Y, Funayama T, Mutou-Yoshihara Y, Ikeda H, Kobayashi Y, Int J Radiat Biol, 91(5), 383-388, 2015.

A mathematical model of the radiation-induced responses in cellular population including cell-to-cell communications. Hattori Y, Suzuki M, Funayama T, Kobayashi Y, Yokoya A and Watanabe R, Radiat Prot Dosimetry, 166, 142-147, 2015.

Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: The relevance to cancer risk. Autsavapromporn N, Plante I, Liu C, Konishi T, Usami N, Funayama T, Azzam E I, Murakami T & Suzuki M, Int J Radiat Biol, 91(1), 62-70, 2015.

2014

加工食品を対象にしたアルキルシクロブタノン法(EN1785)の性能評価.堤智明,足立利華,高附巧,根井大介,亀谷宏美,等々力節子,菊地正博,小林泰彦,松田りえ子,手島玲子,食品照射,49(1),9-15,2014.

Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation. Takahashi A, Kubo M, Hongyu Ma, Nakagawa A, Yoshida Y, Isono M, Kanai T, Ohno T, Furusawa Y, Funayama T, Kobayashi Y and Nakano T, Radiat Res, 182(3), 338-344, 2014.

A branching process model for the analysis of abortive colony size distributions in carbon ion-irradiated normal human fibroblasts. Sakashita T, Hamada N, Kawaguchi I, Hara T, Kobayashi Y, Saito K, J Radiat Res, 55(3), 423-431, 2014.

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells. Murata K, Noda S, Oike T, Takahashi A, Yoshida Y, Suzuki Y, Ohno T, Funayama T, Kobayashi Y, Takahashi T, Nakano T, J Radiat Res, 55(4), 658-664, 2014.

放射線照射食品に誘導されるラジカルのPulse-ESRとCW-ESRによる解析.岸田敬吾,川村翔栄,亀谷宏美,中村秀夫,菊地正博,小林泰彦,鵜飼光子,RAIOISOTOPES,63(3),131-138,2014.

ESRスピントラップ法による放射線照射漢方エキス剤のラジカル捕捉活性評価.太多由依,川村翔栄,菊地正博,小林泰彦,鵜飼光子,中村秀夫,RAIOISOTOPES,63(3),119-130,2014.

2013

Gap Junction Communication and the Propagation of Bystander Effects Induced by Microbeam Irradiation in Human Fibroblast Cultures: The Impact of Radiation Quality. Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou, Y, Ikeda H, Kobayashi K, Kobayashi Y, Uchihori Y, Hei T K, Azzamg E I & Murakami T, Radiat Res, 180(4), 367-375, 2013.

長期保存中に照射食品に誘導されるラジカルの減衰挙動の解析.岸田敬吾,川村翔栄,中村秀夫,菊地正博,小林泰彦,鵜飼光子,食品照射,48(1),11-18,2013.

照射穀類粉に誘導されるラジカルのESRによる解析.川村翔栄,岸田敬吾,菊地正博,小林泰彦,鵜飼光子,食品照射,48(1),3-10,2013.

A framework for analysis of abortive colony size distributions using a model of branching processes in irradiated normal human fibroblasts. Sakashita T, Hamada N, Kawaguchi I, Ouchi NB, Hara T, Kobayashi Y, Saito K, PLoS ONE, 2013, 8, e70291.

Effects of Ion Beam Irradiation on the Expression of Glutathione Peroxidase in Cultured Human Retinal Vascular Endothelial Cells Exposed to L-dopa. Akeo K, Hamada N, Funayama T, Akeo Y, Kobayashi Y, Tiss Cult Res Commun, 32, 195-202, 2013.

2012

Innate immune genes including a mucin-like gene, mul-1, induced by ionizing radiation in Caenorhabditis elegans. Kimura T, Takanami T, Sakashita T, Wada S, Kobayashi Y, Higashitani A, Radiat Res. 178, 313-320, 2012.

Effects of low- and high-LET radiation on the salt chemotaxis learning in Caenorhabditis elegans. Sakashita T, Suzuki M, Hamada N, Shimozawa Y, Shirai-Fukamoto K, Yokota Y, Hamada-Sora S, Kakizaki T, Wada S, Funayama T, Kobayashi Y, Biol Sci Space, 26, 21-25, 2012.

Pulse-ESRとCW-ESRによる照射黒コショウ中のラジカルの緩和時間解析.亀谷宏美,菊地正博,等々力節子,古田雅一,小林泰彦,原英之,下山雄平,鵜飼光子,食品照射,47(1),6-10,2012.

照射処理により食品中に誘導されるラジカルの解析.岸田啓吾,貝森良彦,川村翔栄,坂本侑輝,中村秀夫,菊地正博,下山雄平,小林泰彦,鵜飼光子,食品照射,47(1),1-5,2012.

Electron-spin relaxation phenomena in irradiated saccharides detected by pulsed electron paramagnetic resonance spectroscopy. Kikuchi M, Kameya H, Shimoyama Y, Ukai M, Kobayashi Y, Radiat Phys Chem, 81(10), 1639-1645, 2012.

Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells. Musha A, Yoshida Y, Takahashi,T, Ando ., Funayama T, Kobayashi Y, Negishi A, Yokoo S & Nakano T, J Radiat Res, 53(4), 545-550, 2012.

Behavioral resistance of Caenorhabditis elegans against high-LET radiation exposure. Sakashita T, Suzuki M, Hamada N, Shimozawa Y, Shirai-Fukamoto K, Yokota Y, Hamada-Sora S, Kakizaki T, Wada S, Funayama T, Kobayashi Y, Biol Sci Space, 26, 7-11, 2012.

Involvement of bystander effect in suppression of the cytokine production induced by heavy-ion broad beams. Mutou-Yoshihara Y, Funayama T, Yokota Y and Kobayashi Y, Int J Radiat Biol, 88(3), 258-266, 2012.

Tolerance of anhydrobiotic eggs of the Tardigrade ramazzottius varieornatus to extreme environments. Horikawa D D, Yamaguchi A, Sakashita T, Tanaka D, Hamada N, Yukuhiro F, Kuwahara H, Kunieda T, Watanabe M, Nakahara Y, Wada S, Funayama T, Katagiri C, Higashi S, Yokobori S, Kuwabara M, Rothschild L J, Okuda T, Hashimoto H and Kobayashi Y, Astrobiology, 12(4), 283-289, 2012.

Relaxation Behaviors of Free Radicals from γ-Irradiated Black Pepper using Pulsed EPR Spectroscopy. Kameya H, Kikuchi M, Hara H, Furuta M, Todoriki S, Kobayashi Y, Ukai M and Shimoyama Y, Applied Magnetic Resonance, 42(2), 153-159, 2012

Evaluation of the relative biological effectiveness of carbon ion beams in the cerebellum using the rat organotypic slice culture system. Yoshida Y, Suzuki Y, Al-Jahdari W S, Hamada N, Funayama T, Shirai K, Katoh H, Sakashita T, Kobayashi Y & Nakano T, J Radiat Res, 53(1), 87-92, 2012.

2011

照射食品に誘導されるラジカルの減衰挙動.貝森良彦,坂本侑輝,菊地正博,亀谷宏美,中村秀夫,下山雄平,小林泰彦,鵜飼光子,食品照射,46(1),13-18,2011.

ESR detection procedure of irradiated papaya containing high water content. Kikuchi M, Shimoyama Y, Ukai M, Kobayashi Y, Radiat Phys Chem, 80, 664-667, 2011.

照射された生鮮果物パパイヤの迅速ESR検知法.菊地正博,下山雄平,鵜飼光子,小林泰彦,RADIOISOTOPES,60(4),163-171,2011.

集束式重イオンマイクロビームの大気中ビームサイズの迅速評価方法の検討:CR-39のエッチング時間短縮,及び半自動画像処理.坂下哲哉, 横田裕一郎,舟山知夫,柏木啓次,佐藤隆博,小林泰彦,RADIOISOTOPE,60(2),47-53,2011.

Radiation-induced ICAM-1 expression via TGF-β1 pathway on human umbilical vein endothelial cells; comparison between X-ray and carbon-ion beam irradiation. Kiyohara H, Ishizaki Y, Suzuki Y, Katoh H, Hamada N, Ohno T,Takahashi T, Kobayashi Y, Nakano T, J Radiat Res, 52(3), 287-291, 2011.

Monte carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths. Watanabe R, Wada S, Funayama T, Kobayashi Y, Saito K and Furusawa Y, Radiat Prot Dosimetry, 43(2-4), 186-190, 2011.

2010

Anhydrobiosis-associated nuclear DNA damage and repair in the Sleeping Chironomid: linkage with radioresistance. O. Gusev, Y. Nakahara, V. Vanyagina, L. Malutina, R. Cornette, T. Sakashita, N. Hamada, T. Kikawada, M. Fujita, Y. Kobayashi and T. Okuda., PLoS ONE, e14008, 2010

照射ニンニクのESR、PSL、TLによる検知.亀谷宏美,齊藤希巳江,菊地正博,小林泰彦,鵜飼光子,等々力節子,日本食品科学工学会誌,57(11),472-478,2010.

照射された生鮮果実パパイヤにおけるラジカル緩和現象.菊地正博,垣田大介,下山雄平,岩佐達郎,鵜飼光子,小林泰彦,食品照射,45(1-2),34-38,2010.

放射線照射によるニンニクの萌芽発根抑制効果.小林泰彦,菊地正博,等々力節子,齊藤希巳江,桂洋子,亀谷宏美,市川まりこ,飯塚友子,千葉悦子,鵜飼光子,食品照射,45(1-2),26-33,2010.

照射マンゴー中に誘導されるラジカルの緩和挙動と線量依存性.亀谷宏美,垣田大介,貝森良彦,菊地正博,小林泰彦,鵜飼光子,下山雄平,RADIOISOTOPES,59(10),607-614,2010.

Enhanced micronucleus formation in the descendants of gamma-ray-irradiated tobacco cells: Evidence for radiation-induced genomic instability in plant cells. Y. Yokota, T. Funayama, Y. Hase, N. Hamada, Y. Kobayashi, A. Tanaka and I. Narumi, Mutat. Res.-Fundam. Mol. Mech. Mutagen. 691, 41-46, 2010. (doi: 10.1016/j.mrfmmm.2010.07.001).

ESR Study of Free Radicals in Mango. Masahiro KIKUCHI, Mohammad S. HUSSAIN, Norio MORISHITA, Mitsuko UKAI, Yasuhiko KOBAYASHI and Yuhei SHIMOYAMA, Spectrochim Acta Part A, 75(1), 310-313, 2010.

Irradiation with carbon ion beams induces apoptosis, autophagy, and cellular senescence in a human glioma-derived cell line. Jinno-Oue A, Shimizu N, Hamada N, Wada S, Tanaka A, Shinagawa M, Ohtsuki T, Mori T, Saha MN, Hoque, AS, Islam S, Kogure K, Funayama T, Kobayashi Y, Hoshino H, Int. J. Radiat. Oncol. Biol. Phys. 76(1), 229-241, 2010.

2009

照射マンゴーに誘起されるラジカルの緩和現象.菊地正博,小川英之,森下憲雄,鵜飼光子,小林泰彦,下山雄平,食品照射,44(1-2),9-13,2009.

照射された生マンゴーに誘起されたラジカルのESR測定.菊地正博,Mohammad S.Hussain,森下憲雄,鵜飼光子,下山雄平,小林泰彦,RADIOISOTOPES,58(12),789-797,2009.

The radiobiological effectiveness of carbon-ion beams on growing neurons. Al-Jahdari W S, Suzuki Y, Yoshida Y, Hamada N, Shirai K, Noda S, Funayama T, Sakashita T, Kobayashi Y, Saito S, Goto F and Nakano T, Int J Radiat Biol, 85(8), 700-709, 2009.

Targeted Heavy-Ion Microbeam Irradiation of the Embryo But Not Yolk in the Diapause-Terminated Egg of the Silkworm, Bombyx mori, Induces The Somatic Mutation. Toshiharu FURUSAWA, Kana FUKAMOTO, Tetsuya SAKASHITA, Eiko SUZUKI, Takehiko KAKIZAKI, Nobuyuki HAMADA, Tomoo FUNAYAMA, Hiromi SUZUKI, Noriaki ISHIOKA, Seiichi WADA, Yasuhiko KOBAYASHI and Shunji NAGAOKA, J. Radiat. Res. 50(4), 371-375, 2009.

Kinetic analysis of double-strand break rejoining reveals the DNAreparability of gamma-irradiated tobacco cultured cells. YuichiroYokota, Seiichi Wada, Yoshihiro Hase, Tomoo Funayama, YasuhikoKobayashi, Issay Narumi, and Atsushi Tanaka, J. Radiat. Res. 50(2), 170-175, 2009.

Ceramide induces myogenic differentiation and apoptosis in Drosophila Schneider cells. Hidemasa Kawamura, Kazuaki Tatei, Tetsuo Nonaka, HideruObinata, Tomoyasu Hattori, Ai Ogawa, Hideko Kazama, Nobuyuki Hamada,Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Takashi Nakano,and Takashi Izumi, J. Radiat. Res., 50(2), 161-169, 2009.

Effects of Ionizing Radiation on Locomotory Behavior andMechanosensation in Caenorhabditis elegans. Michiyo Suzuki,Tetsuya Sakashita, Sumino Yanase, Masahiro Kikuchi, HirofumiOhba, Atsushi Higashitani, Nobuyuki Hamada, Tomoo Funayama, Kana Fukamoto, Toshio Tsuji, and Yasuhiko Kobayashi, J. Radiat. Res. 50(2), 119-125, 2009.

Microbeam Irradiation Facilities for Radiobiology in Japan and China. Yasuhiko KOBAYASHI, Tomoo FUNAYAMA, Nobuyuki HAMADA, Tetsuya SAKASHITA, Teruaki KONISHI, Hitoshi IMASEKI, Keisuke YASUDA, Masanori HATASHITA, Keiichi TAKAGI, Satoshi HATORI, Keiji SUZUKI, Motohiro YAMAUCHI, Shunichi YAMASHITA, Masanori TOMITA, Munetoshi MAEDA, Katsumi KOBAYASHI, Noriko USAMI and Lijun WU, J. Radiat. Res., 50: Suppl., A29-A47, 2009.

Expanding the Question-answering Potential of Single-cell Microbeams at RARAF, USA. Bigelow A, Garty G, Funayama T, Randers-Pehrson G, Brenner D & Geard C, J. Radiat. Res., 50: Suppl., A21-A28, 2009.

Insufficient membrane fusion in dysferlin-deficient muscle fibers after heavy-ion irradiation. Mizuki Hino, Nobuyuki Hamada, Yuki Tajika, Tomoo Funayama, Yoshihiro Morimura, Tetsuya Sakashita, Yuichiro Yokota, Kana Fukamoto, Yasuhiko Kobayashi, and Hiroshi Yorifuji, Cell Struct. Funct. 34, 11-15, 2009.

Heavy-ion induced bystander killing of human lung cancer cells: the role of gap junctional intercellular communication. Kosaku Harada, Tetsuo Nonaka, Nobuyuki Hamada, Hideyuki Sakurai, Masatoshi Hasegawa, Tomoo Funayama, Takehiko Kakizaki, Yasuhiko Kobayashi, and Takashi Nakano, Cancer Sci. 100(4), 684-688, 2009.

Status of food irradiation in the world. Tamikazu Kume, Masakazu Furuta, Setsuko Todoriki, Naoki Uenoyama and Yasuhiko Kobayashi, Radiat. Phys. Chem. 78, 222-226, 2009.

Quantity and Economic Scale of Food Irradiation in the World. Tamikazu Kume, Masakazu Furuta, Setsuko Todoriki, Naoki Uenoyama and Yasuhiko Kobayashi, RADIOISOTOPES, 58(1), 25-35, 2009.

No evidence for DNA and early cytogenetic damage in bystander cells following heavy ion micro-irradiation at two facilities. Claudia Fournier, Philippe Barberet, Thomas Pouthier, Sylvia Ritter, Bernd Fischer, Kay-Obbe Voss, Tomoo Funayama, Nobuyuki Hamada, Yasuhiko Kobayashi, and Gisela Taucher-Scholz, Radiat Res. 171, 530-540, 2009.

2008

A LET-dependent decrease in the apoptotic response of normal human fibroblast cultures to isosurvival doses of gamma-rays and energetic heavy ions. Nobuyuki Hamada, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: 41-45, 2008.

Heavy-ion microbeam irradiation induces bystander killing of human cells. Nobuyuki Hamada, Takamitsu Hara, Motoko Omura-Minamisawa, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: 46-53, 2008.

Exposure of normal human fibroblasts to heavy-ion radiation promotes their morphological differentiation. Sakura Sora, Nobuyuki Hamada, Takamitsu Hara, Tomoo Funayama, Tetsuya Sakashita, Yuichiro Yokota, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: 54-58, 2008.

The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation. Nobuyuki Hamada, Keiko Kataoka, Sakura Sora, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Takashi Nakano, and Yasuhiko Kobayashi. Radiother. Oncol. 89: 227-230, 2008.

Energetic heavy ions overcome tumor radioresistance caused by overexpression of Bcl-2. Nobuyuki Hamada, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Yuichiro Yokota, Takashi Nakano, and Yasuhiko Kobayashi. Radiother. Oncol. 89: 231-236, 2008.

The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny. Nobuyuki Hamada, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Cancer Lett. 268: 76-81, 2008.

A LET-dependent decrease in the apoptotic response of normal human fibroblast cultures to isosurvival doses of gamma-rays and energetic heavy ions. Nobuyuki Hamada, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Sakura Sora, Takashi Nakano, and Yasuhiko Kobayashi. Biol. Sci. Space 22: in press, 2008.

Establishment of a rearing system of the extremotolerant tardigradeRamazzottius varieornatus: a new model animal for astrobiology. Daiki D.Horikawa, Takekazu Kunieda, Wataru Abe, Masahiko Watanabe, Yuichi Nakahara,Fumiko Yukuhiro, Tetsuya Sakashita, Nobuyuki Hamada, Seiichi Wada, TomooFunayama, Chihiro Katagiri, Yasuhiko Kobayashi, Seigo Higashi, and TakashiOkuda. Astrobiology, 8: 557-568, 2008.

Effects of Locally Targeted Heavy-ion and Laser Microbeam on RootHydrotropism in Arabidopsis thaliana. Yutaka Miyazawa, Tetsuya Sakashita,Tomoo Funayama, Nobuyuki Hamada, Hiroshi Negishi, Akie Kobayashi, TomokoKaneyasu, Atsushi Ooba, Keita Morohashi, Takehiko Kakizaki, Seiichi Wada,Yasuhiko Kobayashi, Nobuharu Fujii, and Hideyuki Takahashi. J. Radiat. Res.49: 373-379, 2008.

Expression profiles are different in carbon ion-irradiated normal humanfibroblasts and their bystander cells. Mayumi Iwakawa, Nobuyuki Hamada,Kaori Imadome, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, andTakashi Imai. Mutat. Res. 642: 57-67, 2008.

Proliferation and cell death of human glioblastoma cells after carbon-ion beam exposure: morphologic and morphometric analyses. Takuma Oishi, Atsushi Sasaki, Nobuyuk Hamada, Shogo Ishiuchi, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Takashi Nakano, and Yoichi Nakazato. Neuropathology 28: 408-416, 2008.

Locomotion – learning behevior relationship in Caenorhabditis elegans following gamma-ray irradiation. Tetsuya Sakashita, Nobuyuki Hamada, Daisuke D. Ikeda, Michiyo Suzuki, Sumino Yanase, Naoaki Ishii, and Yasuhiko Kobayashi. J. Radiat. Res. 49: 285-291, 2008.

Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions. Nobuyuki Hamada, Meinan Ni, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Mutat. Res. 639: 35-44, 2008.

Modulatory effect of ionizing radiation on food-NaCl associative learning: The role of γ subunit of G protein in Caenorhabditis elegans. Tetsuya Sakashita, Nobuyuki Hamada, Daisuke D. Ikeda, Sumino Yanase, Michiyo Suzuki, Naoaki Ishii and Yasuhiko Kobayashi, FASEB J. 22:713-720, 2008.

Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts. Nobuyuki Hamada, Takamitsu Hara, Tomoo Funayama, Tetsuya Sakashita, Yasuhiko Kobayashi, Mutat. Res. 637: 190-196, 2008.

Heavy-ion microbeam system at JAEA-Takasaki for Microbeam Biology. Tomoo Funayama, Seiichi Wada, Yuichiro Yokota, Kana Fukamoto, Tetsuya Sakashita Mitsumasa Taguchi, Takehiko Kakizaki, Nobuyuki Hamada, Michiyo Suzuki, Yoshiya Furusawa, Hiroshi Watanabe, Kenji Kiguchi, and Yasuhiko Kobayashi, J. Radiat. Res. 49: 71-82, 2008.

2007

Effects of γ-ray irradiation on olfactory adaptation to benzaldehyde in Caenorhabditis elegans, Sakashita T, Hamada N, Suzuki M, Ikeda DD, Yanase S, Ishii N, Kobayashi Y, Biological Sciences in Space 21:117-120, 2007.

The effects of ultraviolet irradiation and hypoxia on expression of glutathione peroxidase and glyceraldehyde 3-phosphate dehydrogenase in the cultured retinal pigment epithelium. Kiyoshi Akeo, Tomoo Funayama, Nobuyuki Hamada, Yoko Akeo, Tadahisa Hiramitsu, and Yasuhiko Kobayashi. Tissue Cult. Res. Commun., 26: 149-157, 2007.

Chemiluminescence ELISA for the detection of oxidative DNA base damage using anti-8-hydroxy-2'-deoxyguanosine antibody: application to the detection of irradiated foods. Masahiro KIKUCHI, Chaminda R. GUNAWARDANE, Md. Khorshed ALAM, A. Zainuri Mohd. DZOMIR, Ramya C. Pitipanaarachchi, Tomoo FUNAYAMA, Nobuyuki HAMADA, Tetsuya SAKASHITA, Seiichi WADA, Katsuya SATOH, Issay NARUMI and Yasuhiko KOBAYASHI, RADIOISOTOPES 56: 509-517, 2007

Heavy Ion Microbeam Irradiation Induces Ultrastructural Changes in Isolated Single Fibers of Skeletal Muscle. Hino M., Wada S., Tajika Y., Morimura Y., Hamada N., Funayama T., Sakashita T., Kakizaki T., Kobayashi Y. and Yorifuji H. Cell Struct. Funct. 32: 51-56, 2007.

Physiological changes leading to anhydrobiosis improve radiation tolerance in Polypedilum vanderplanki larvae. Watanabe M., Nakahara Y., Sakashita T., Kikawada T., Fujita A., Hamada N., Horikawa D. D., Wada S., Kobayashi Y., Okuda T. J. Insect Physiology 53(6), 573-579, 2007

Vulnerability of feline T-lymphocytes to charged particles. Kakizaki T., Hamada N., Sakashita T., Wada S., Hara T., Funayama T., Hohdatsu T., Natsuhori M., Sano T., Kobayashi Y., and Ito N. J. Vet. Med. Sci. 48: 97-106, 2007.

Development of the Irradiation Method for the First Instar Silkworm Larvae Using Locally Targeted Heavy-ion Microbeam. Fukamoto K., Shirai K., Sakata T., Sakashita T., Funayama T., Hamada N., Wada S., Kakizaki T., Shimura S., Kobayashi Y. and Kiguchi K. J. Radiat. Res. 48, 247-253, 2007

Role of DNA-PKcs in the bystander effect after low- or high-LET irradiation. Kanasugi Y, Hamada N., Wada S., Funayama T., Sakashita T., Kakizaki T., Kobayashi Y., Takakura K. Int. J. Radiat. Biol. 83: 73-80, 2007.

2006

Estimation of radiation tolerance against high LET heavy ions in an anhydrobiotic insect, Polypedilum vanderplanki. Watanabe M., Sakashita T., Fujita A., Kikawada T., Nakahara Y., Hamada N., Horikawa D.D., Wada S., Funayama T., Kobayashi Y., Okuda T. Int. J. Radiat. Biol. 82: 835-842, 2006.

Radiation tolerance in the tardigrade Milnesium tardigradum. Horikawa D.D., Sakashita T., Katagiri C., Watanabe M., Kikawada T., Nakahara Y., Hamada N., Wada S., Funayama T., Higashi S., Kobayashi Y., Okuda T., Kuwabara M. Int. J. Radiat. Biol. 82: 843-848, 2006.

Killing of Feline T-Lymphocytes by Gamma-Rays and Energetic Carbon Ions. Kakizaki T., Hamada N., Funayama T., Sakashita T., Wada S., Hohdatsu T., Natsuhori M., Sano T., Kobayashi Y., Ito N. J. Vet. Med. Sci. 68: 1269-1273, 2006.

Distinct Modes of Cell Death by Ionizing Radiation Observed in Two Lines of Feline T-Lymphocytes. Kakizaki T., Hamada N., Wada S., Funayama T., Sakashita T., Hohdatsu T., Sano T., Natsuhori M., Kobayashi Y., Ito N. J. Radiat. Res. 47(3-4):237-243, 2006.

Process of in vivo cyst formation from the implanted larval integument in the sweet potato hornworm, Agrius convolvuli: A simple model for studying wound healing. Fukamoto K., Shirai K., Sato S., Kanekatsu R., Kiguchi K., Kobayashi Y. J. Insect Baiotechnol. Sericol. 75:99-106, 2006.

Effects of heavy-ion irradiation on the differentiation of epidermal cells in the silkworm, Bombyx mori. Fukamoto K., Shimura S., Shirai K., Kanekatsu R., Kiguchi K., Sakashita T., Funayama T., Kobayashi Y. J. Insect Baiotechnol. Sericol. 75:107-114, 2006.

Biological effects of anhydrobiosis in an African chironomid, Polypedilum vanderplanki on radiation tolerance. Watanabe M., Sakashita T., Fujita A., Kikawada T., Horikawa D.D., Nakahara Y., Wada S., Funayama T., Hamada N., Kobayashi Y., Okuda T. Int. J. Radiat. Biol. 82:587-592, 2006.

Effects of gamma irradiation on bcl-2 and p53 expression in the porcine ciliary body. Akeo K., Funayama T., Ogawa A., Hamada N., Akeo Y., Kobayashi Y. Exp. Anim. 55(4):375-381, 2006.

LET-Dependent Survival of Irradiated Normal Human Fibroblasts and Their Descendents. Hamada N., Funayama T., Wada S., Sakashita S., Kakizaki T., Ni M., Kobayashi Y. Radiat. Res. 166:24-30, 2006.

Differential effects of x-irradiation on immature and mature hippocampal neurons in vitro. Shirai K., Mizui T., Suzuki Y., Kobayashi Y., Nakano T., Shirao T. Neuroscience Letters 399:57-60, 2006.

Method for detecting DNA strand breaks in mammalian cells using the Deinococcus radiodurans PprA protein. Satoh K, Wada S, Kikuchi M, Funayama T, Narumi I, Kobayashi Y. Mutat. Res. 596:36-42, 2006.

Cell cycle arrest and apoptosis in Caenorhabditis elegans germline cells following heavy-ion microbeam irradiation. Sugimoto T., Dazai K., Sakashita T, Funayama T., Wada S., Hamada N., Kakizaki T., Kobayashi Y., Higashitani A. Int. J. Radiat. Biol. 82:31-38, 2006.

Contribution of circulating hemocytes to the regeneration of heavy ion beams (12C5+) irradiated hematopoietic organs in the silkworm, Bombyx mori, through the way of phagocytosis of injured cells after invasion. Ling E., Shirai K., Kanekatsu R., Kiguchi K., Kobayashi Y., Funayama T. Watanabe H. Developmental & Comparative Immunology 30(6):531-543, 2006.

2005

Exploration of 'Over Kill Effect' of High-LET Ar- and Fe-ions by Evaluating the Fraction of Non-hit Cell and Interphase Death. Mehnati P., Morimoto S., Yatagai F., Furusawa Y., Kobayashi Y., Wada S., Kanai T., Hanaoka F. and Sasaki H. J. Radiat. Res. 46(3):343-350, 2005.

Comparative radiation tolerance based on the induction of DNA double-strand breaks in tobacco BY-2 cells and CHO-K1 cells irradiated with gamma rays. Yokota Y, Shikazono N, Tanaka A, Hase Y, Funayama T, Wada S, Inoue M. Radiat. Res. 163:520-525, 2005.

Irradiation of mammalian cultured cells with collimated heavy ion microbeam. Funayama T., Wada S., Kobayashi Y., Watanabe H. Radiat. Res. 163:241-246, 2005.

Characterization of pathways dependent on the uvsE, uvrA1, or uvrA2 gene product for ultraviolet resistance in Deinococcus radiodurans. Tanaka M, Narumi I, Funayama T, Kikuchi M, Watanabe H, Matsunaga T, Nikaido O, Yamamoto K. J. Bacteriol. 187:3693-3697, 2005.

Prediction of Cellular Radiosensitivity from DNA Damage Induced by ƒÁ-Rays and Carbon Ion Irradiation in Canine Tumor Cells. Wada S., Khoa T.V., Kobayashi Y., Funayama T., Ogihara K., Ueno S., Ito N. J. Vet. Med. Sci. 67(11):1089-1095, 2005.

2004

Light dependency of resistance to ionizing radiation in Euglena gracilis. Hayashi H, Narumi I, Wada S, Kikuchi M, Furuta M, Uehara K, Watanabe H. J. Plant Physiol. 161:1101-1106, 2004.

PprA: a novel protein from Deinococcus radiodurans that stimulates DNA ligation. Narumi I, Satoh K, Cui S, Funayama T, Kitayama S, Watanabe H. Mol. Microbiol. 54:278-285, 2004.

Evaluation of the resistance of Euglena gracilis to ion beam radiation. Hayashi H, Wada S, Funayama T, Narumi I, Kobayashi Y, Watanabe H, Furuta M, Uehara K. J. Eukaryot. Microbiol. 51:321-324, 2004.

2003

Development of an ion microbeam system for irradiating single plant cell[s]. Yokota Y, Funayama T, Kobayashi Y, Sakashita T, Wada S, Hase Y, Shikazono N, Tanaka A, Inoue M. Biol. Sci. Space 17:298-301, 2003.

Detection of Radiation-Induced Apoptosis Using the Comet Assay. Wada S., Khoa T.V., Kobayashi Y., Funayama T., Yamamoto K., Natsuhori M., Ito N. J. Vet. Med. Sci. 65(11):1161-1166, 2003.

Bystander effect induced by counted high-LET particles in confluent human fibroblasts: A mechanistic study. Shao C., Furusawa Y., Kobayashi Y., Funayama T., Wada S. The FASEB Journal 17:1422-1427, 2003.

Regeneration of hemopoietic organs in the silkworm, Bombyx mori, after locally targeted irradiation with heavy ion beams. Ling E., Fukamoto K., Xu S., Shirai K., Kanetatsu R., Kobayashi Y., Tu Z.L., Funayama T., Watanabe H., Kiguchi K. J. Insect Biotechnol. Sericol. 72(2): 95-100, 2003.

Why does hemocyte density rise during the wandering stage of the silkworm, Bombyx mori? Ling E., Shirai K., Kanetatsu R., Kobayashi Y., Tu Z.L., Funayama T., Watanabe H., Kiguchi K. J. Insect Biotechnol. Sericol. 72(2):101-109, 2003.

The Relationship between Cellular Radiosensitivity and Radiation-Induced DNA Damage Measured by the Comet Assay. Wada S., Kurahashi H., Kobayashi Y., Funayama T., Yamamoto K., Natsuhori M., Ito N. J. Vet. Med. Sci.i 65(4):471-477, 2003.

Irradiation of single mammalian cells with a precise number of energetic heavy ions - Applications of microbeams for studying cellular radiation response. Kobayashi Y., Funayama T., Wada S., Taguchi M., Watanabe H. Nucl. Inst. and Methods in Phys. Res., B210:308-311, 2003.

Radiosurgery using heavy ion microbeams for biological study: Fate mapping of the cellular blastderm-stage egg of the silkworm, Bombyx mori. Kiguchi K., Shirai K., Kanekatsu R., Kobayashi Y., Tu Z.L., Funayama T., Watanabe H. Nucl. Inst. and Methods in Phys. Res., B210:312-315, 2003.

Detection of DNA damage induced by heavy ion irradiation in the individual cells with comet assay. Wada S., Natsuhori M., Ito N., Funayama T., Kobayashi Y. Nucl. Inst. and Methods in Phys. Res., B206:553-556, 2003.

Irradiation effect of different heavy ions and track section on the silkworm Bombyx mori. Tu Z.L., Kobayashi Y., Kiguchi K., Watanabe H. Nucl. Inst. and Methods in Phys. Res., B206:591-595, 2003.

照射糖培養液の微生物生育に及ぼす影響.伊藤均,食品照射,38(1,2):6-10,2003.

著書・総説・解説

菊地正博&小林泰彦,農学と放射線化学-イオンビーム育種,照射食品検知法-.RADIOISOTOPES,66:611-616,2017.

冨田雅典,松本英樹&舟山知夫,重イオン線によるバイスタンダー応答の特徴.放射線生物研究,51:324-335,2016.

舟山知夫,横田裕一郎&鈴木芳代,量研機構・高崎の重イオンマイクロビーム.放射線生物研究,51:336-356,2016.

放射線の効果を細胞から細胞へ伝えるバイスタンダー効果の特徴 -鍵を握るのは一酸化窒素-.横田裕一郎,舟山知夫,池田裕子,小林泰彦,Isotope News,No.741,21-25,2016.

第15回国際放射線研究会議(ICRR2015)参加記(放射線生物学関連分野).小林泰彦,放射線と産業,No.139,44-45,2015.

放射化学の事典,「放射線殺菌・滅菌」「芽止め照射」.小林泰彦,朝倉書店,2015年

放射線「作用」の本質的な特徴は何か.小林泰彦,環境と健康,28(2),129-139,2015

放射線殺菌の原理と食品照射の国際動向.小林泰彦,ソフト・ドリンク技術資料,No.175,103-128,2015.

食品照射の基礎知識と国際動向.小林泰彦,FFIジャーナル,220(1),52-63,2015.

放射線殺菌と海外情報.小林泰彦,食品衛生学雑誌,56(1),J14-J18,2015.

食品の安全と安心講座I考える材料と見る視点(松田友義編)pp.52-69,第6章「放射性物質による食品汚染を考える」.小林泰彦,幸書房,2015年

原子力・量子・核融合事典第4分冊:量子ビームと放射線医療,「食品照射:放射線による食品や農作物の殺菌・殺虫・芽止め技術」.小林泰彦,丸善,2014年

新しい形の食品照射のコミュニケーション活動.小林泰彦,食品照射,49(1),116-117,2014.

知らせたいことを伝えるのではなく、知りたいことに丁寧に答える.小林泰彦,食品照射,49(1),127-128,2014.

ヒト正常細胞のコロニー形成実験から明らかになった新事実.浜田信行,坂下哲哉,原孝光,藤通有希,放射線生物研究,49(3),318-331,2014.

水産環境の放射性物質汚染による健康影響.小林泰彦,海洋と生物,Vol.36(3),269-276,2014.

ケンカ白熱教室! 放射能はどこまで安全か?.小出裕章,小林泰彦,幻冬舎,2013年

低線量放射線影響とバイスタンダー効果 —放射線が当たった細胞から当たっていない細胞への情報伝達—.小林泰彦,獣医畜産新報,66(12),909-913,2013

医学物理の理工学(上巻),pp.239-250,「重イオンマイクロビームを用いた細胞1個の狙い撃ち照射」.小林泰彦,養賢堂,2012年

放射能と食の安全 ~食品中の放射性物質の「基準値」の意味~.小林泰彦,日本機械学会誌,115,No.1126,669,2012.

放射線・放射能の基礎と食品の安全性について ~誤解を解き無用の不安を減らすために~.小林泰彦,食品の包装,Vol.43(2),71-79,2012.

市民のためのしゃべり場みんなで語る『食の安全と放射線・放射能』印象記.小林泰彦,Isotope News,No.692,18-19,2011.

モデルとしての線虫に観る放射線の生物への影響と研究の展開.坂下哲哉,鈴木芳代,放射線と産業,No.131,37-41,2011.

市民のためのしゃべり場『食べ物に放射線?』印象記.小林泰彦,Isotope News,No.684,26-27,2011.

原子力教科書放射線利用,pp.159-208,第14章「重イオンマイクロビームを用いた細胞局部照射実験」,第15章「食品照射:放射線による食品や農作物の殺菌・殺虫・芽止め技術」.小林泰彦,オーム社、2011年

Recent Advances in the Biology of Heavy-Ion Cancer Therapy. Nobuyuki HAMADA, Tatsuhiko IMAOKA, Shin-ichiro MASUNAGA, Toshiyuki OGATA, Ryuichi OKAYASU, Akihisa TAKAHASHI, Takamitsu A. KATO, Yasuhiko KOBAYASHI, Takeo OHNISHI, Koji ONO, Yoshiya SHIMADA and Teruki TESHIMA, J Radiat Res, 51(4), 365-383, 2010.

REVIEW: Radiation biology of Caenorhabditis elegans: Germ cell response, aging and behavior. Tetsuya SAKASHITA, Takako TAKANAMI, Sumino YANASE, Nobuyuki HAMADA, Michiyo SUZUKI, Takafumi KIMURA, Yasuhiko KOBAYASHI, Naoaki ISHII and Atsushi HIGASHITANI, J Radiat Res, 51(2), 107-121, 2010.

線虫C.elegansにおける運動と学習を指標とした放射線影響解析.坂下哲哉,鈴木芳代,放射線生物研究,46(1),30-46,2010.

日本におけるシステム放射線生物学(SRB)の胎動.坂下哲哉,鈴木芳代,大内則幸,伴信彦,放射線生物研究,45(4),379-395,2010.

重イオンマイクロビームの生物学研究への応用.小林泰彦,Isotope News,No.670,6-10,2010.

食品照射:放射線による食品や農作物の殺菌・殺虫・芽止め技術.小林泰彦,菊地正博,放射線化学,第88号,18-27,2009.

マイクロビームを用いたバイスタンダー効果の研究.小林泰彦,JAPIニューズレター,12(5),2-7,2009.

マイクロビームを用いたバイスタンダー効果の研究.小林泰彦,放射線と産業,No.124,27-31,2009.

原子力機構TIARAのマイクロビーム装置によるバイスタンダー効果研究.舟山知夫,横田裕一郎,坂下哲哉,小林泰彦,Isotope News, No.669,7-11,2009.

Bcl-2は重粒子線治療の標的となるか.浜田信行,原孝光,片岡啓子,楚良桜,小林泰彦,放射線生物研究,44(2),216-225,2009.

浜田信行、岩川眞由美、今井高志、小林泰彦:重粒子線誘発バイスタンダー効果 -照射された細胞から照射されていない周囲の細胞への情報伝達-、放射線科学、51(8):31-41,2008.

Heavy-ion microbeams – development and applications in biological studies.Tomoo Funayama, Nobuyuki Hamada, Tetsuya Sakashita, Yasuhiko Kobayashi. IEEE Trans. Plasma Sci. 36: 1432-1440, 2008.

小林泰彦、舟山知夫、浜田信行、坂下哲哉、横田裕一郎、深本花菜、鈴木芳代、田口光正:重イオンマイクロビームを用いた生物学的研究、放射線生物研究、43:150-169,2008.

「高等植物の放射線耐性メカニズム—タバコ培養細胞における損傷とその修復から見えてくること」横田裕一郎、放射線生物研究,42(4),402-415,2007.

「第13回国際放射線研究会議(ICRR2007)に参加して」横田裕一郎、放射線と産業,第116号,53-55,2007.

「重イオンマイクロビームを用いた細胞1個の狙い撃ち照射」小林泰彦,真空,50(9),564-568,2007.

「アメリカに留学して感じたこと」舟山知夫,放射線と産業,第112号:45-50,2006.

Intercellular and Intracelllar Signaling Pathways Mediating Ionising Radiation-Induced Bystander Effects. Hamada N., Matsumoto H., Hara T., Kobayashi Y. J. Radiat. Res. 48: 87-95, 2007.

Vanguards of paradigm shift in radiation biology: Radioadaptive response and radiation-induced bystander response.Matsumoto H., Hamada N., Takahashi A., Kobayashi Y., Ohnishi T. J. Radiat. Res. 48: 97-106, 2007.

講座「細胞局部照射実験の歴史と粒子線マイクロビームのマイクロサージャリへの応用」小林泰彦,RADIOISOTOPES,55(5):281-292,2006.

「マイクロビームによる細胞のピンポイント照射」小林泰彦,放射線と産業,第108号:21-25,2005.

「食品照射と検知法」小林泰彦,放影研ニュース,No.44:15-16,2005.

「生物の放射線耐性と進化」渡辺宏,鳴海一成,菊地正博,小林泰彦,放射線31:191-202,2005.

Microbeams of heavy charged particles. Kobayashi Y., Funayama T., Wada S., Furusawa Y., Aoki M., Shao C., Yokota Y., Sakashita T., Matsumoto Y., Kakizaki T., Hamada N. Biol. Sci. Space 18:235-240,2004.

「イオンビーム局部照射による微細外科手術 ーカイコの造血器官・血球の機能解析への応用ー」 小林泰彦, 木口憲爾, Isotope News 2003年9月号,No.593:9-12,2003.

「細胞をシングルイオン照射したときに何が起こるか ー放射線応答研究のためのマイクロビームによる細胞照射実験ー」小林泰彦,舟山知夫,Isotope News 2003年6月号,No.590:2-7,2003.

「病人食や宇宙食にも利用 ー食品照射の原理と安全性ー」小林泰彦,日本原子力文化振興財団月報6月号,No.242:1-3,2003.

「日本における食品照射の開発の経緯と今後の課題」伊藤均,食品照射,38(1,2):23-30,2003.

「マイクロビームによる細胞局部照射の試み ー紫外線から重粒子線までー」小林泰彦.放射線生物研究,37(1):67-84,2002.

「第2回宇宙放射線研究国際ワークショップに参加して」和田成一.放射線生物研究,37(2):221-223,2002.

「原研・高崎研・生物照射用マイクロビーム装置の現状」舟山知夫,小林泰彦.放射線生物研究,37(3):334-347,2002.

「植物の形態形成分子機構の研究 —イオンビームによる植物細胞アポトーシス誘導体の確立—」川合真紀,小林泰彦,大野豊,渡辺宏,内宮博文,基礎科学ノート,8(1):9-12,2001.

「放射線利用における品質管理・線量計測の現状 —バイオ分野のイオンビーム利用研究における線量計測」小林泰彦,放射線と産業,第89号:26-31,2001.

「マイクロビーム探訪の旅」舟山知夫,放射線と産業,第91号:56-61,2001.

「マイクロビームによる生物照射の現状と将来展望」渡辺宏,小林泰彦,Isotope News 2000年2月号,No.549:2-5,2000.

「マイクロビームでミクロの外科手術」木口憲爾,小林泰彦,放射線と産業,第85号:30-36,2000.

 

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