Measurement technology has always supported the development of science. The paradigm shift in life sciences has also always been caused by novel measurement techniques. And today in science, we are required increasingly to measure the nano world in the living system with extreme accuracy. In recent years, with significant advances in quantum technology, “quantum” (NV center) contained in a diamond crystal is likely to play the key role in such measurements. Our group develops the “future biomeasurement technology” that visualize the nano world in the living system through the eyes of quantum. This technology is expected to provide new avenues toward analyses of complex life phenomena such as aging, carcinogenesis and neural activity.
Team Leader, Ryuji Igarashi
Recent Publications
- Virus Detection using Second Harmonics of Magnetic Nanoparticles Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Igarashi Ryuji, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata IEEJ Transactions on Electrical and Electronic Engineering, 17 (8), 1228 - 1230, 2022-08, DOI:10.1002/tee.23613
- No Intercellular Regulation of the Cell Cycle among Human Cervical Carcinoma HeLa Cells Expressing Fluorescent Ubiquitination-Based Cell-Cycle Indicators in Modulated Radiation Fields Hisanori Fukunaga, Kaminaga Kiichi, Hirose Eri, Watanabe Ritsuko, Noriko Usami, Kevin M. Prise, Yokoya Akinari Molecular Science, 22(23), 12785, 2021-12, DOI:10.3390/ijms222312785
- A simple and soft chemical deaggregation method producing single-digit detonation nanodiamonds Terada Daiki, Frederick So, Bodo Hattendorf, Yanagi Tamami, Eiji Ōsawa, Norikazu Mizuochi, Shirakawa Masahiro, Igarashi Ryuji, Takuya Fabian Segawa Nanoscale Advances, 4(10), 2268 - 2277, 2022-03, DOI:10.1039/D1NA00556A
- The Anomalous Formation of Irradiation Induced Nitrogen-Vacancy Centers in 5-Nanometer-Sized Detonation Nanodiamonds Frederick T.K So, Alexander I. Shames, Terada Daiki, Genjo Takuya, Hiroki Morishita, Ohki Izuru, Ohshima Takeshi, Onoda Shinobu, Hideaki Takashima, Shigeki Takeuchi, Norikazu Mizuochi, Igarashi Ryuji, Shirakawa Masahiro, Takuya F. Segawa The Anomalous Formation of Irradiation Induced Nitrogen-Vacancy Centers in 5-Nanometer-Sized Detonation Nanodiamonds The Journal of Physical Chemistry C, 126(11), 5206 - 5217, 2022-03, DOI:10.1021/acs.jpcc.1c10466
- Bridging mRNA and Polycation using RNA Oligonucleotide Derivatives Improves the Robustness of Polyplex Micelles for Efficient mRNA Delivery Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka Advanced healthcare materials, 11(9), 2102016, 2022-12, DOI:10.1002/adhm.202102016
- Overcoming humidity-induced swelling of graphene oxide-based hydrogen membranes using charge-compensating nanodiamonds Guoji Huang, Behnam Ghalei, Ali Pournaghshband Isfahani, H. Karahan, Daiki Terada, Detao Qin, Conger Li, Masahiko Tsujimoto, Daisuke Yamaguchi, Kunihisa Sugimoto, Ryuji Igarashi, Bor Kae Chang, Tao Li, Masahiro Shirakawa, Easan Sivaniah Nature Energy, 6, 1176 - 1187, 2021-12, DOI:10.1038/s41560-021-00946-y
- Non-contact Measurement of Internal Body Temperature Using Subcutaneously Implanted Diamond Microparticles Kaminaga Kiichi, Yanagihara Hiromi, Genjo Takuya, Morioka Takamitsu, Abe Hiroshi, Shirakawa Masahiro, Ohshima Takeshi, Kakinuma Shizuko, Igarashi Ryuji Biomaterials Science, 9(21), 7049 - 7053, 2021-09, DOI:10.1039/D1BM01187A
- All-Optical Wide-Field Selective Imaging of Fluorescent Nanodiamonds in Cells, In Vivo and Ex Vivo Tamami Yanagi, Kiichi Kaminaga, Michiyo Suzuki, Hiroshi Abe, Hiroki Yamamoto, Takeshi Ohshima, Akihiro Kuwahata, , Masaki Sekino, Tatsuhiko Imaoka, Shizuko Kakinuma, Takuma Sugi, Wataru Kada, Osamu Hanaizumi, Ryuji Igarashi ACS Nano, 15(8), 12869 - 12879, 2021-08, DOI:10.1021/acsnano.0c07740
- PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials Naoto Yoshinaga , Mitsuru Naito , Yoshihiro Tachihara , Eger Boonstra , Kensuke Osada , Horacio Cabral , Satoshi Uchida Pharmaceutics, , 2022-01, DOI:10.3390/pharmaceutics13060800
- Machine-Learning Optimization of Multiple Measurement Parameters Nonlinearly Affecting the Signal Quality Fujisaku Takahiro, Frederick So, Igarashi Ryuji, Shirakawa Masahiro ACS Measurement Science Au, 1, 20 - 26, 2021-07, DOI:10.1021/acsmeasuresciau.1c00009
- Calcium imaging in freely behaving Caenorhabditis elegans with well-controlled, nonlocalized vibrations Kazuki Shigyou, Haruka Maeoka, Ryuji Igarashi, Takuma Sugi Journal of Visualized Experiments, 170, e61626, 2021-05, DOI:10.3791/61626
- Distance measurements between 5-nanometer diamonds – Single particle magnetic resonance or optical super-resolution imaging? Dorothea Pinotsi,Rui Tian,Pratyush Anand, Koichiro Miyanishi, Jens M. Boss, Kevin Kai Chang,Pol Welter,Frederick T.-K. So, Daiki Terada, Ryuji Igarashi, Masahiro Shirakawa, Christian L. Degenb, Takuya F. Segawa Nanoscale Advances, 2023-01 DOI https://doi.org/10.1039/D2NA00815G
- Rapid Virus Detection using Magnetic Second Harmonics of Superparamagnetic Iron Oxide Nanoparticles Ryuichi Hirota , Toru Murayama , Ryota Katsumi , Tokuhisa Kawawaki , Shin Yabukami , Igarashi Ryuji , Yuichi Negishi , Moriaki Kusakabe , Masaki Sekino , Takashi Yatsui , Akihiro Kuwahata AIP Advances, , 2023-01
- Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues. Mitsuru Naito , Yusuke Watanuki , Kazuko Toh , Jongmin Yum , Beob Soo Kim , Kaori Taniwaki , Satomi Ogura , Hiroki Ishida , Masaru Cho , Hiroyuki Chaya , Ken Miyajima , Yuichi Yamasaki , Kensuke Osada , Katsura Minegishi , Yoshitsugu Aoki , Kanjiro Miyata ournal of controlled release : official journal of the Controlled Release Society, 347, 607 - 614, 2022-07, DOI:10.1016/j.jconrel.2022.05.030
- Nanoscale quantum sensing with nitrogen-vacancy centers in nanodiamonds — A magnetic resonance perspective Takuya F. Segawa , Ryuji Igarashi Progress in Nuclear Magnetic Resonance Spectroscopy, 134-135, 20 - 38, 2023-01, DOI:10.1016/j.pnmrs.2022.12.001