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Institute for Quantum Life Science

DNA Damage Chemistry Team

Update:2024年1月30日更新
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DNA損傷タイトル

DNA損傷DNA that controls the inheritance of organisms is always damaged in cells. The number of lesions is tens of thousands per cell per day! These lesions- DNA damage- are caused not only by external factors such as chemicals, ultraviolet light and ionizing radiation, but also by internal factors such as oxygen respiration. However, organisms have acquired various DNA damage repair methods in the process of evolution. The chemical structure of DNA damage is diverse. Which repair process is selected to repair a given DNA damage? Or is there a damage impossible to be repaired at all? We will elucidate these issues using quantum technologies.

Team Leader, Ken Akamatsu

 

Recent Publications

Yusuke Sato, Yoshihide Takaku, Toshiaki Nakano, Ken Akamatsu, Dai Inamura, and Seiichi Nishizawa; Synthetic DNA binders for fluorescence sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity, Chem. Commun.59, 6088-6091 (2023)
 
K. Moribayashi, H. Matsubara, Y.Yonetani, N. Shikazono; Multi-Scale Simulations Aiming To Advance Heavy Ion Beam Cancer Therapy, API conference proceedings, 2756, 030001/1-8 (2023)​