Mutagenesis is known to be associated with carcinogenesis, and thus is closely related to the essence of life. The generation of mutation or cancer is known to depend on how radiation passes energy to the living cells. That is, mutagenic and carcinogenic effects are affected by the types of radiation such as γ rays and ion beams. We believe that looking into the mechanism that causes the difference by the types of radiation will enable us to approach the fundamental nature of life. In this research group, we aim to understand the mechanism of mutagenesis and carcinogenesis through searching for novel fast processes at an extremely small area caused by radiation in addition to conventional processes such as ionizations and excitations.
Team Leader, Naoya Shikazono
Publications
Moribayashi, K. (2023) Effect of the thermalization of secondary electron energies on plasma formation during the irradiation of heavy ions. NIMB 537: 129-132.
Moribayashi, K. (2023) Effect of closeness between a few atoms forming a cluster ion passing through water on the motion of secondary electrons and radial dose. Radiat. Phys. Chem. 208: 110870.
Nakano, T., Moriwak,i T., Tsuda, M., Miyakawa, M., Hanaichi, Y., Sasanuma, H., Hirota, K., Kawanishi, M., Ide, H., Tano, K., and Bessho, T. (2022) SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2'-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line. Chem. Res. Toxicol. 35: 2059-2067.
Nakano, T., Akamatsu, K., Tsuda, M., Tujimoto, A., Hirayama, R., Hiromoto, T., Tamada, T., Ide, H., and Shikazono, N. (2022) Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy. Proc. Natl. Acad. Sci. USA. 119: e2119132119.
Akamatsu, K., Shikazono, N., and Saito T. (2021) Fluorescence anisotropy study of radiation-inudced DNA damage clustereing based on FRET. Anal. Bioanal. Chem. 413: 1185-1192.
Hase, Y., Satoh, K., Chiba, A., Hirano, Y., Moribayashi, K., and Narumi, K. (2021) Proton-Cluster-Beam Lethality and Mutagenicity in Bacillus subtilis Spores. Quantum Beam Sci. 5: 25.
Moribayashi, K. (2021) Debye shield formed by track potential and transport of secondary electrons in heavy ion irradiation. Radiat. Phys. Chem. 184: 109436.
Shikazono N, Akamatsu K. (2020) Strand with mutagenic lesion is preferentially used as a template in the region of a bi-stranded clustered DNA damage site in Escherichia coli. Sci. Rep. 10: 9737.
Du, Y., Hase, Y., Satoh, K., and Shikazono, N. (2020) Characterization of gamma irradiation-induced mutations in Arabidopsis mutants deficient in non-homologous end joining. J. Radiat. Res. 61: 639–647.
Nakano, T., Shoulkamy, M.I., Tsuda, M., Sasanuma, H., Hirota, K., Takata, M., Masunaga, S,I., Takeda, S., Ide, H., Bessho, T., and Tano, K..(2020) Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells. PLoS One 15: e0234859.
Tsuda, M., Kitamasu, K., Kumagai, C., Sugiyama, K., Nakano, T., and Ide, H. (2020) Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1). DNA repair 92: 102849
Xu, X., Nakano, T., Tsuda, M., Kanamoto, R., Hirayama, R., Uzawa, A., and Ide, H. (2020) Direct observation of damage clustering in irradiated DNA with atomic force microscopy. Nuclei Acids Res. 48: e18.
Matsuya, Y., Nakano, T., Kai, T., Shikazono, N., Akamatsu, K., Yoshii, Y., and Sato, T. (2020) A Simplified Cluster Analysis of Electron Track Structure for Estimating Complex DNA Damage Yields. Int. J. Mol. Sci. 21: 1701.
Tsuda, M., Kitamasu, K., Hosokawa, S., Nakano, T., and Ide, H. (2020) Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms. Nucleosides Nucleotides Nucleic Acids 39:170-184.
Hase, Y., Satoh, K., Chiba, A., Hirano, Y., Tomita, S., Saito, Y., and Narumi, K. (2019) Experimental Study on the Biological Effect of Cluster Ion Beams in Bacillus subtilis Spores. Quantum Beam Sci. 3: 8.
Moribayashi, K. (2019) Radial dose distribution model independent of species of incident ions. NIMB 458: 190-195.
Moribayashi, K. (2019) Heat diffusion in heavy-ion beam irradiation. X-ray Spectrometry 48: 708-711.