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Institute for Quantum Life Science

Quantum Cancer Science Team

Update:2024年1月24日更新
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量子発がんタイトル

放射線発がんの図

A tiny invisible change―which the quantum energy of radiation puts in a molecule of a living thing―can trigger a sequence of events leading to a visible consequence. It is believed that subtle modifications of DNA at the atomic/molecular level initiate cellular and tissue changes, resulting in cancer at the individual level, but most of the things are still hypothetical. Some quantum technologies, which are good at measuring tiny changes in the body, can be our ideal partners in the quest of deciphering the mechanism underlying radiation induction of cancer. More specifically, very early stages of cancer may involve changes in the DNA of a cell, behavior of cells and the environment surrounding the cell. We aim to understand these invisible changes by maximally utilizing the potential of quantum technologies.

Team Leader, Tatsuhiko, Imaoka

Recent Publications

  1. Suzuki Kenshi,  Tsuruoka Chizuru,  Morioka Takamitsu,  Seo Hitomi,  Ogawa Mari,  Imaoka Tatsuhiko,  Kakinuma Shizuko,  Takahashi Akihisa. Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 ApcMin/+ mice. Life Sciences in Space Research (submitted)
  2. Shang Yi,  Morioka Takamitsu,  Daino Kazuhiro,  Nakayama Takafumi,  Nishimura Mayumi,  Kakinuma Shizuko. Ionizing radiation promotes, whereas calorie restriction suppresses, NASH and hepatocellular carcinoma in mice. International Journal of Cancer, , 2023-07, DOI:10.1002/ijc.34651
  3. Semba Ryoko,  Morioka Takamitsu,  Yanagihara Hiromi,  Suzuki Kenshi,  Tachibana Hirotaka,  Hamoya Takahiro,  Horimoto Yoshiya,  Imaoka Tatsuhiko,  Saito Mitsue,  Kakinuma Shizuko,  Arai Masami. Azithromycin induces read-through of the nonsense Apc allele and prevents intestinal tumorigenesis in C3B6F1 ApcMin/+ mice. Biomedicine & Pharmacotherapy , 164, 2023-06, DOI:https://doi.org/10.1016/j.biopha.2023.114968
  4. Hiromi Yanagihara,  Takamitsu Morioka,  Shunsuke Yamazaki,  Yutaka Yamada,  Hirotaka Tachibana,  Kazuhiro Daino,  Chizuru Tsuruoka,  Yoshiko Amasaki,  Mutsumi Kaminishi,  Tatsuhiko Imaoka,  Shizuko Kakinuma. Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice. Journal of radiation research, 64(3), 622 - 631, 2023-05