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Institute for Quantum Life Science

Quantum Life Informatics Team

Update：2025年4月1日更新
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量子生命情報タイトル

Uncovering Life Mechanisms Across Hierarchial Levels with Advanced Information Analysis Techniques

Informatics for quantum life science

In living organisms, interactions between different scales of hierarchy—such as molecules, cells, tissues, and organs—maintain the integrity of life. Our team tackles a fundamental problem in life sciences: how phenomena occurring at specific hierarchical levels affect other levels and reflect in the biological behavior of an individual organism. We utilize advanced information science technologies, including AI, machine learning, and quantum computing, while incorporating novel measurement technologies like quantum sensing and hyperpolarized MRI, which are being developed at our institute. These technologies provide bio-parameters that help deepen our understanding of life phenomena across multiple hierarchical levels. Currently, our research focuses on three main themes:

  1. Development of a data-driven analysis platform that reveals the relationship between an individual's state (such as cognition and behavior) and its neural and molecular substrates based on neuroimaging data and various neuropsychological parameters.
  2. Development of novel algorithms based on quantum computing technologies (such as quantum-inspired computing and quantum annealing machines) to achieve fast analysis of high-dimensional spatiotemporal data.
  3.  Evaluation of the efficacy of quantum mechanics’ mathematical framework for understanding macroscopic life phenomena (i.e., to assess the potential benefits of applying quantum mechanics' mathematical framework to explain large-scale biological processes, such as psychological and neural functions).

 

Members

八幡チームリーダー

Team Leader, Noriaki Yahata

Researcher: Kei Majima, Guohua Shen, Zhilei Zhao, Yasuhiko Tachibana​

 

Recent Publications

  • Dong D, Hosomi K, Shimizu T, Okada KI, Kadono Y, Mori N, Hori Y, Yahata N, Hirabayashi T, Kishima H, Saitoh Y. Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques. J Pain. 25(12):104661 (2024)
  • Zhao Z, Okada N, Yagishita S, Yahata N, Nitta N, Shibata S, Abe Y, Morita S, Kumagai E, Tanaka KF, Suhara T, Takumi T, Kasai K, Jinde S. Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism. Neurosci Res. 209:42-49 (2024)
  • Itahashi T, Yamashita A, Takahara Y, Yahata N, Aoki YY, Fujino J, Yoshihara Y, Nakamura M, Aoki R, Okimura T, Ohta H, Sakai Y, Takamura M, Ichikawa N, Okada G, Okada N, Kasai K, Tanaka SC, Imamizu H, Kato N, Okamoto Y, Takahashi H, Kawato M, Yamashita O, Hashimoto RI. Generalizable and transportable resting-state neural signatures characterized by functional networks, neurotransmitters, and clinical symptoms in autism. Mol Psychiatry. (2024)
  • Oyama K, Majima K, Nagai Y, Hori Y, Hirabayashi T, Eldridge MAG, Mimura K, Miyakawa N, Fujimoto A, Hori Y, Iwaoki H, Inoue KI, Saunders RC, Takada M, Yahata N, Higuchi M, Richmond BJ, Minamimoto T. Distinct roles of monkey OFC-subcortical pathways in adaptive behavior. Nat Commun. 15(1):6487 (2024)
  • Fukuma R, Majima K, Kawahara Y, Yamashita O, Shiraishi Y, Kishima H, Yanagisawa T. Fast, accurate, and interpretable decoding of electrocorticographic signals using dynamic mode decomposition. Commun Biol. 7(1):595 (2024)
  • Koide-Majima N, Nishimoto S, Majima K. Mental image reconstruction from human brain activity: Neural decoding of mental imagery via deep neural network-based Bayesian estimation. Neural Netw. 170:349-363 (2024)
  • Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Edden RAE, Sawa A, Kasai K. Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization. Mol Psychiatry. 29(4):939-950 (2024)
  • Sato Y, Okada G, Yokoyama S, Ichikawa N, Takamura M, Mitsuyama Y, Shimizu A, Itai E, Shinzato H, Kawato M, Yahata N, Okamoto Y. Resting-state functional connectivity disruption between the left and right pallidum as a biomarker for subthreshold depression. Sci Rep. 13(1):6349. (2023)
  • Takeuchi H, Yahata N, Lisi G, Tsurumi K, Yoshihara Y, Kawada R, Murao T, Mizuta H, Yokomoto T, Miyagi T, Nakagami Y, Yoshioka T, Yoshimoto J, Kawato M, Murai T, Morimoto J, Takahashi H. Development of a classifier for gambling disorder based on functional connections between brain regions. Psychiatry Clin Neurosci. 76(6):260-267 (2022)
  • Koide-Majima N Majima K. Fast and scalable classical machine-learning algorithm with similar performance to quantum circuit learning. Physical Review A. 104(6): 062411 (2021)
  • Okada N, Yamamoto Y, Yahata N, Morita S, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Yokoyama C, Kasai K. Birth order and prosociality in the early adolescent brain. Sci Rep. 11(1):21806 (2021)
  • Mimura K, Nagai Y, Inoue K.I, Matsumoto J, Hori Y, Sato C, Kimura K, Okauchi T, Hirabayashi T, Nishijo H, Yahata N, Takada M, Suhara T, Higuchi M, Minamimoto T. Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets. iScience. 24(9):103066 (2021)
  • Tanaka S.C, Yamashita A, Yahata N, Itahashi T, Lisi G, Yamada T, Ichikawa N, Takamura M, Yoshihara Y, Kunimatsu A, Okada N, Hashimoto R, Okada G, Sakai Y, Morimoto J, Narumoto J, Shimada Y, Mano H, Yoshida W, Seymour B, Shimizu T, Hosomi K, Saitoh Y, Kasai K, Kato N, Takahashi H, Okamoto Y, Yamashita O, Kawato M, Imamizu H. A multi-site, multi-disorder resting-state magnetic resonance image database. Sci Data. 8(1):227 (2021)
  • Okamoto Y, Kitada R, Tanabe H.C, Sasaki A.T, Kochiyama T, Yahata N, Sadato N. The extrastriate body area is involved in reciprocal imitation of hand gestures, vocalizations, and facial expressions: A univariate and multivariate fMRI study. Soc Neurosci. 16(4):448-465 (2021)
  • Takagi Y, Okada N, Ando S, Yahata N, Morita K, Koshiyama D, Kawakami S, Sawada K, Koike S, Endo K, Yamasaki S, Nishida A, Kasai K, Tanaka S.C. Intergenerational transmission of the patterns of functional and structural brain networks. iScience. 24(7):102708 (2021)
  • Yamashita A, Sakai Y, Yamada T, Yahata N, Kunimatsu A, Okada N, Itahashi T, Hashimoto R, Mizuta H, Ichikawa N, Takamura M, Okada G, Yamagata H, Harada K, Matsuo K, Tanaka SC, Kawato M, Kasai K, Kato N, Takahashi H, Okamoto Y, Yamashita O, Imamizu H. Common Brain Networks Between Major Depressive-Disorder Diagnosis and Symptoms of Depression That Are Validated for Independent Cohorts. Front Psychiatry. 12:667881 (2021)
  • Koide-Majima N, Majima K. Quantum-inspired canonical correlation analysis for exponentially large dimensional data. Neural Netw. 135:55-67. (2021)
  • Yamashita A, Sakai Y, Yamada T, Yahata N, Kunimatsu A, Okada N, Itahashi T, Hashimoto R, Mizuta H, Ichikawa N, Takamura M, Okada G, Yamagata H, Harada K, Matsuo K, Tanaka SC, Kawato M, Kasai K, Kato N, Takahashi H, Okamoto Y, Yamashita O, Imamizu H. Generalizable brain network markers of major depressive disorder across multiple imaging sites. PLoS Biol. 18(12):e3000966 (2020)
  • Koshiyama D, Okada N, Ando S, Koike S, Yahata N, Morita K, Sawada K, Morita S, Kawakami S, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Araki T, Kano Y, Endo K, Yamasaki S, Nishida A, Hiraiwa-Hasegawa M, Kasai K. Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence. Neuroimage. 220:117083 (2020)
  • Itahashi T, Okada N, Ando S, Yamasaki S, Koshiyama D, Morita K, Yahata N, Koike S, Nishida A, Kasai K, Hashimoto RI. Functional connectomes linking child-parent relationships with psychological problems in adolescence. Neuroimage. 219:117013 (2020)
  • Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Edden RAE, Sawa A, Kasai K, Neurometabolic underpinning of the intergenerational transmission of prosociality. Neuroimage. 218:116965 (2020)
  • Yoshihara Y, Lisi G, Yahata N, Fujino J, Matsumoto Y, Miyata J, Sugihara GI, Urayama SI, Kubota M, Yamashita M, Hashimoto R, Ichikawa N, Cahn W, van Haren NEM, Mori S, Okamoto Y, Kasai K, Kato N, Imamizu H, Kahn RS, Sawa A, Kawato M, Murai T, Morimoto J, Takahashi H. Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity. Schizophr Bull. 46(5):1210-1218 (2020)
  • Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Kasai K. Smaller Anterior Subgenual Cingulate Volume Mediates the Effect of Girls’ Early Sexual Maturation on Negative Psychobehavioral Outcome. Neuroimage. 209:116478 (2020)
  • Ichikawa N, Lisi G, Yahata N, Okada G, Takamura M, Hashimoto R, Yamada T, Yamada M, Suhara T, Moriguchi Sho, Mimura M, Yoshihara Y, Takahashi H, Kasai K, Kato N, Yamawaki S, Seymour Ben, Kawato M, Morimoto J, Okamoto Y. Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants. Scientific Reports. 10(1):3542 (2020)
  • Grandjean J, Canella C, Anckaerts C, Ayrancı G, Bougacha S, Bienert T, Buehlmann D, Coletta L, Gallino D, Gass N, Garin CM, Nadkarni NA, Hübner NS, Karatas M, Komaki Y, Kreitz S, Mandino F, Mechling AE, Sato C, Sauer K, Shah D, Strobelt S, Takata N, Wank I, Wu T, Yahata N, Yeow LY, Yee Y, Aoki I, Chakravarty MM, Chang WT, Dhenain M, von Elverfeldt D, Harsan LA, Hess A, Jiang T, Keliris GA, Lerch JP, Meyer-Lindenberg A, Okano H, Rudin M Sartorius A, Van der Linden A, Verhoye M, Weber-Fahr W, Wenderoth N, Zerbi V, Gozzi A. Common Functional Networks in the Mouse Brain Revealed by Multi-Centre Resting-State fMRI Analysis. Neuroimage. 205:116278 (2020)
  • Okada N, Ando S, Sanada M, Hirata-Mogi S, Iijima Y, Sugiyama H, Shirakawa T, Yamagishi M, Kanehara A, Morita M, Yagi T, Hayashi N, Koshiyama D, Morita K, Sawada K, Ikegame T, Sugimoto N, Toriyama R, Masaoka M, Fujikawa S, Kanata S, Tada M, Kirihara K, Yahata N, Araki T, Jinde S, Kano Y, Koike S, Endo K, Yamasaki S, Nishida A, Hiraiwa-Hasegawa M, Bundo M, Iwamoto K, Tanaka SC, Kasai K. Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development. Psychiatry Clin Neurosci. 73(5):231-242 (2019)
  • Yamashita A, Yahata N, Itahashi T, Lisi G, Yamada T, Ichikawa N, Takamura M, Yoshihara Y, Kunimatsu A, Okada N, Yamagata H, Matsuo K, Hashimoto R, Okada G, Sakai Y, Morimoto J, Narumoto J, Shimada Y, Kasai K, Kato N, Takahashi H, Okamoto Y, Tanaka SC, Kawato M, Yamashita O, Imamizu H. Harmonization of resting-state functional MRI data across multiple imaging sites via the separation of site differences into sampling bias and measurement bias. PLoS Biol. 17(4):e3000042 (2019)
  • Iwashiro N, Takano Y, Natsubori T, Aoki Y, Yahata N, Gonoi W, Kunimatsu A, Abe O, Kasai K, Yamasue H. Aberrant attentive and inattentive brain activity to auditory negative words and its relation to persecutory delusion in patients with schizophrenia. Neuropsychiatr Dis Treat. 15:491-502 (2019)
  • Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Edden RAE, Barker PB, Sawa A, Kasai K. Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence. Sci Rep. 9(1):732 (2019)
Institute for Quantum Life Science