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Institute for Quantum Life Science

Quantum Regenerative and Biomedical Engineering Team

Update：2025年4月8日更新
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量子再生タイトル

量子再生概要図In regenerative medicine, there is concern that the differences of cellular states of stem cells and regenerated cells affect the regenerative functions such as the production of regeneration factors, differentiation ability, homing ability, and sensing ability. In this team, we aim to develop the measurement technology of cell statement of stem cells and regenerative cells by quantum nano censer such as nitrogen vacancy center fluorescent nano-diamonds (NVC nano-diamonds) for regenerative function diagnostics. NVC nano-diamonds is known to be able to measure and detect the temperature and pH concentration in the surrounding environment. In recent years, NVC nano-diamonds have been applied for the measurement of cellular temperature and pH concentration in mainly cancer cells such as HeLa cells. However, little is known about the application of NVC nano-diamonds for the measurement of cellular states of stem cells and regenerative cells. In this team, we newly develop the measurement technology of cellular state of stem cells, regenerative cells, matured cells existed in spheroids by NVC nano-diamonds for regenerative function diagnostics. We then elucidate the correlation between the cellular state of stem cells or regenerative cells and the regenerative function using this technology. In addition, we establish the technology that can detect and measure the cellular temperature, flexibility, and pH concentration of transplanted stem cells and regenerated cells in vivo or intra vital of mice.

 

​湯川チームリーダ

 

 

 

 

Team Leader, Hiroshi Yukawa

 

Publications

​2025​

  1. Yukawa H., Kono H., Ishiwata H., Igarashi R., Takakusagi Y., Arai S., Hirano Y., Suhara T., Baba Y. Quantum life science: biological nano quantum sensors, quantum technology-based hyperpolarized MRI/NMR, quantum biology, and quantum biotechnology,Chem. Soc. Rev. 2025; 54: 3293-3322.
  2. Shimada T., Yasui T., Yukawa H., Baba Y. Nanobiodevices and quantum life science for future healthcare, Anal. Sci. 2025.

2024

  1. Shimada T., Ueda Y., Takemaru H., Baba Y., Yukawa H. Nano-quantum sensors-based imaging and sensing for target-based drug discovery and development, Trends Analyt. Chem. 2024; 171: 117496.
  2. Yamada S., Yamada K., Sugawara A., Baba Y., Yukawa H. Near-infrared-II fluorescence/magnetic resonance double modal imaging of transplanted stem cells using lanthanide co-doped gadolinium oxide nanoparticles, Anal. Sci., 2024; 40: 1043-1050. Hot Article in 2024
  3. Takahashi T., Zhang H., Agetsuma M., Nabekura J., Otomo K., Okamura Y., Nemoto T. Large-scale cranial window for in vivo mouse brain imaging utilizing fluoropolymer nanosheet and light-curable resin, Commun. Biol. 2024; 7: 232.
  4. Rikiyama K., Maehara N., Abe H., Nishimura Y., Yukawa H., Kaminaga K., Igarashi R., Osada K. Quantification of Poly(ethylene glycol) Crowding on Nanodiamonds toward Quantum Biosensor for Improved Prevention Effects on Protein Adsorption and Lung Accumulation, Langmuir 2024; 40(18): 9471–9480
  5. Iwatake M., Nagamura-Inoue T., Doi R., Tanoue Y., Ishii M., Yukawa H., Tsuchiya T. Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models, Front. Immunol. 2024; 15: 1384718.
  6. Miki K., Oe M., Suzuki K., Miki K., Mu H., Kato Y., Iwatake M., Yukawa H., Baba Y., Ueda Y., Mori Y., Ohe K. Dual-Responsive Near-Infrared Turn-On Fluorescent Probe for Cancer Stem Cell-Specific Visualization, J. Mater. Chem. B 2024; 12: 6959-6967.
  7. Shimada T., Ueda Y., Baba Y., Yukawa H. Advances of Fluorescent Nanodiamond Platforms for Intracellular and On-Chip Biosensing, Biosensors 2024; 14(7): 340.
  8. Iwatake M., Morita S., Takahashi K., Sato K., Miyagi-Shiohira C., Noguchi H., Baba Y., Yukawa H. Establishment of a stem cell administration imaging method in bleomycin-induced pulmonary fibrosis mouse models, Sci. Rep. 2024; 14: 18905.
  9. Onoshima D., Uchida K., Iida T., Kojima T., Ikeda Y., Iwata D., Nagasawa I., Yukawa H., Baba Y. Single-cell detection and linear discriminant analysis of bacterial Raman spectra in glass filter microholes, Anal. Methods 2024; 16(39): 6746-6750.
  10. Yasui T., Natsume A., Yanagida T., Nagashima K., Washio T., Ichikawa Y., Chattrairat K., Naganawa T., Iida M., Kitano Y., Aoki K., Mizunuma M., Shimada T., Takayama K., Ochiya T., Kawai T., Baba Y. Early Cancer Detection via Multi-microRNA Profiling of Urinary Exosomes Captured by Nanowires, Anal. Chem. 2024; 96(43): 17145–17153.
  11. Asano T., Suga H., Niioka H., Yukawa H., Sakakibara M., Taga S., Soen M., Miwata T., Sasaki H., Seki T., Hasegawa S., Murakami S., Abe M., Yasuda Y., Miyata T., Kobayashi T., Sugiyama M., Onoue T., Hagiwara D., Iwama S., Baba Y., Iwama S. A deep learning approach to predict differentiation outcomes in hypothalamic pituitary organoids, Commun. Biol. 2024; 7: 1468.
  12. Ueda Y., Tsukahara K., Hasumi M., Uyama K., Yukawa H., Kato T., Toda T., Ohta S., Nishii K. Cis-1,4-specific polymerization of 1,3-conjugated dienes with bis (benzimidazole) NiCl2 catalyst system, Polymer 2024; 315: 127806.
  13. Ogino T., Agetsuma M., Sawada M., Inada H., Nabekura J., Sawamoto K. Astrocytic activation increases blood flow in the adult olfactory bulb, Molecular Brain 2024; 17: 52.
  14. Miyagawa A., Ito C., Ueda Y., Nagatomo S., Nakatani K. DNA sensing based on aggregation of Janus particles using dynamic light scattering, Anal. Chim. Acta. 2024; 1318: 342933.
  15. Agetsuma M., Sato I., Tanaka Y.R., Carrillo-Reid L. Dissecting Neural Population Dynamics: Elastic Net and Conditional Random Fields for Deciphering Functional Networks and Information Processing in Learning and Memory, Neuromethods ("Identification, Characterization, and Manipulation of Neuronal Ensembles”) 2024; vol 215: 195-218.

2023

  1. Shimada T., Takeshita D., Ito S., Yasui T., Baba Y. MicroRNA Extraction from Extracellular Vesicles in Body Fluids Using PMMA-based Nanowire Devices, BUNSEKI KAGAKU. 2023; 72: 105-110.
  2. Chattrairat K., Yasui T., Suzuki S., Natsume A., Nagashima K., Iida M., Zhang M., Shimada T., Kato A., Aoki K., Ohka F., Yamazaki S., Yanagida T., Baba Y. All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an ex Vivo Brain Tumor Model, ACS nano 2023; 17(3): 2235-2244.
  3. Carrillo-Reid L., Agetsuma M., Kropff E. Editorial: Reconfiguration of Neuronal Ensembles Throughout Learning, Front. Syst. Neurosci 2023; 17: 1161967.
  4. *Onoshima D., Sato R., Yukawa H., Nohira K., Min H., Baba Y. Development of Sampling and Measurement Technology for Indoor Particulate Matter Using a Small Drone, Earozoru Kenkyu 2023; 38(1): 30-32.
  5. Yamada S., *Yukawa H., Kitamura K., Mizumaki T., Yoshizumi Y., Oohara T., Nanizawa E., Hirano F., Sato K., Sugawara-Narutaki A., Ishikawa T., Baba Y. In vivo real-time quantum dots imaging to track transplanted adipose stem cells in different inflammatory states of acute liver failure mice, Cell Transplant. 2023; 32: 1-11.
  6. Hasegawa K., Raudales J. L. M., Takashi I., Yoshida T., Honma R., Iwatake M., Tran S. D., Seki M., Asahina I., Sumita Y. Effective-mononuclear cell (E-MNC) therapy alleviates salivary gland damage by suppressing lymphocyte infiltration in Sjögren-like disease, Front. Bioeng. Biotechnol. 2023; 11: 1144624.
  7. *Yukawa H., Sato K., Baba Y. Theranostics applications of quantum dots in regenerative medicine, cancer medicine, and infectious diseases, Adv. Drug Deliv. Rev. 2023; 200: 1114863. Front Cover
  8. Takahashi H., Yasui T., Hirano M., Shinjo K., Miyazaki Y., Shinoda W., Hasegawa T., Natsume A., Kitano Y., Ida M., Zhang M., Shimada T., Paisrisarn P., Zhu Z., Ohka F., Aoki K., Rahong S., Nagashima K., Yanagida T., Baba Y. Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy, Biosens. Bioelectron. 2023; 234: 115318.
  9. Hisanaga M., Tsuchiya T., Watanabe H., Shimoyama K., Iwatake M., Tanoue Y., Maruyama K., Yukawa H., Sato K., Kato Y., Matsumoto K., Miyazaki T., Doi R., Tomoshige K., Nagayasu T. Adipose-Derived Mesenchymal Stem Cells Attenuate Immune Reactions Against Pig Decellularized Bronchi Engrafted into Rat Tracheal Defects, Organogenesis 2023; 19(1): 2212582.
  10. Honma R., Takashi I., Seki M., Iwatake M., Ogaeri T., Hasegawa K., Ohba S., Tran S. D., Asahina I., Sumita Y. Immunomodulatory Macrophages Enable E-MNC Therapy for Radiation-Induced Salivary Gland Hypofunction, Cells 2023; 12(10): 1417.
  11. Mizoguchi S., Tsuchiya T., Doi R., Obata T., Iwatake M., Matsumoto H., Yukawa H., Hayashi H., Li T. S., Yamamoto K., Matsumoto K., Miyazaki T., Tomoshige K., Nagayasu T. A novel ex vivo lung cancer model based on bioengineered rat lungs, Front. Bioeng. Biotechnol. 2023; 11: 1179830.
  12. Yokoi A., Ukai M., Yasui T, Inokuma Y., Hyeon-Deuk K., Matsuzaki J., Yoshida K., Kitagawa M., Chattrairat K., Iida M., Shimada T., Manabe Y., Chang I, Asano-Inami E., Koya Y., Nawa A., Nakamura K., Kiyono T., Kato T., Hirakawa A., Yoshioka Y., Ochiya T., Hasegawa T., Baba Y., Yamamoto Y., Kajiyama H. Identifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowires, Sci. Adv. 2023; 9(27): eade6958.
  13. Kishimoto T., Agetsuma M., Hoshino A., Takahashi H. Needle‐type pressure sensor with silicone oil and parylene membrane inside for minimally invasive measurement, Elec. Commun. Jap. 2023; 106(3): E12420.
  14. Matsuoka K., Yamada M., Fukatsu N., Goto K., Shimizu M., Kato A., Kato Y., Yukawa H., Baba Y., Sato M., Sato K. Contrast-enhanced ultrasound imaging for monitoring the efficacy of near-infrared photoimmunotherapy, eBioMedicine 2023; 95: 104737.
  15. *Agetsuma M., Sato I., Tanaka Y., Carrillo-Reid L., Kasai A., Noritake A., Arai Y., Yoshitomo M., Inagaki T., Yukawa H., Hashimoto H., Nabekura J., Nagai T. Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation, Nat. Commun. 2023; 14(1): 5996. (*: corresponding author)
  16. Tanoue Y., Tsuchiya T., Miyazaki T., Iwatake M., Watanabe H., Yukawa H., Sato K., Hatachi G., Shimoyama K., Matsumoto K., Doi R., Tomoshige K., Nagayasu T. Timing of Mesenchymal Stromal Cell Therapy Defines its Immunosuppressive Effects in a Rat Lung Transplantation Model, Cell Transplant. 2023; 32.
  17. Shimada T., Fujino K., Yasui T., Kaji N., Ueda Y., Fujii K., Yukawa H., Baba Y. Resistive pulse sensing on a capillary-assisted microfluidic plat-form for on-site single particle analyses, Anal. Chem. 2023; 95(50): 18335-18343.

2022​

  1. Minchuan L., *Yukawa H., Baba Y. Micro/Nano-fluidic devices and in vivo fluorescence imaging based on quantum dots for cytologic diagnosis, Lab on a Chip 2022; 22: 2223-2236. Front Cover
  2. Oshimi K., Nishimura Y., Matsubara T., Tanaka M., Shikoh E., Zhao L., Zou Y., Komatsu N., Ikado Y., Takezawa Y., Kage-Nakadai E., Izutsu Y., Yoshizato K., Morita S., Tokunaga M., Yukawa H., Baba Y., Teki Y., *Fujiwara M. Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples, Lab on a Chip 2022; 22: 2519-2530. Back Cover, Hot Article in 2022.
  3. Minchuan L., *Yukawa H., *Baba Y. Fluorescent/magnetic nano-aggregation via electrostatic force between modified quantum dot and iron oxide nanoparticles for bimodal imaging of U87MG tumor cells, Anal. Sci. 2022; 38: 1141-1147. Front Cover, Hot Article in 2022.
  4. Minchuan L., *Yukawa H., Sato K., Tozawa M., Tokunaga M., Kameyama T., Torimoto T., *Baba Y. Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of Targeted Tumors, ACS Appl. Mater. Interfaces 2022; 14(30): 34365–34376.
  5. Yamada S., *Yukawa H., Yamada K., Murata Y., Jo J., Yamamoto M., Sugawara-Narutaki A., Tabata Y., Baba Y. In vivo multimodal imaging of stem cells using nanohybrid particles incorporating quantum dots and magnetic nanoparticles, Sensors 2022; 22(15): 5705.
  6. *Takahashi K., Yasui H., Taki S., Shimizu M., Koike C., Taki K., Yukawa H., Baba Y., Kobayashi H., *Sato K. Near-infrared-induced drug release from antibody–drug double conjugates exerts a cytotoxic photo-bystander effect, Bioeng. Transl. Med. 2022; 7(3): e10388.
  7. †Yoshida M., †Yukawa H., Hayashi K., Naitoh I., Miyabe K., Hori Y., Natsume M., Jinno N., Kato A., Kachi K., Asano G., Sahashi H., Toyohara Y., Kuno K., Kito Y., Kondo H., Hirano A., Okumura F., Anbe K., Baba Y., Kataoka H., *Tanaka Y. Clinical impact of bile-derived exosomal miRNAs as novel diagnostic and prognostic biomarkers for biliary tract cancers, Cancer Sci. 2022; 114(1): 295-305. †Equal contribution.
  8. Tabata H., Sasaki M., Agetsuma M., Sano H., Hirota Y., Miyajima M., Hayashi K., Honda T., Nishikawa M., Inaguma Y., Ito H., Takebayashi H., Ema M., Ikenaka K., Nabekura J., Nagata K., Nakajima K. Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex, Nat. Commun. 2022; 13(1): 6571.
  9. Onoshima D., Hase T., Kihara N., Kuboyama D., Tanaka H., Ozawa N., Yukawa H., Sato M., Ishikawa K., Hasegawa Y., Ishii M., Hori M., Baba Y. Leukocyte depletion and size-based enrichment of circulating tumor cells using a pressure-sensing microfiltration device, ACS Meas. Sci. Au 2022; 3(2): 113-119.
  10. Nakase I., Miyai M., Noguchi K., Tamura M., Yamamoto Y., Nishimura Y., Omura M., Hayashi K., Futaki S., Tokonami S., Iida T. Light-Induced Condensation of Biofunctional Molecules around Targeted Living Cells to Accelerate Cytosolic Delivery, Nano Lett. 2022; 22(24): 9805-9814.

2021​

  1. Nishimura Y., Oshimi K., Umehara Y., Kumon Y., Miyaji K., Yukawa H., Shikano Y., Matsubara T., *Fujiwara M., Baba Y., Teki Y. Wide-field fluorescent nanodiamond spin measurements toward real-time large-area intracellular thermometry, Sci. Rep. 2021; 11(1): 4248.
  2. *Yukawa H., Yamazaki S., Aoki K., Muto K., Kihara N., Sato K., Onoshima D., Ochiya T., Tanaka Y., *Baba Y. Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA, Sci. Rep. 2021; 11(1): 8672.
  3. Rismaningsih N., Yamauchi H., Kameyama T., Yamamoto T., Morita S., Yukawa H., Uematsu T., Baba Y., Kuwabata S., Torimoto T. Photoluminescence properties of quinary Ag–(In,Ga)–(S,Se) quantum dots with a gradient alloy structure for in vivo bioimaging, J. Mater. Chem. C 2021; 9(34): 12791-12801.

2020​

  1. *Yukawa H., *Fujiwara M., Kobayashi K., Miyaji K., Kumon Y., Nishimura Y., Oshimi K., Umehara Y., Teki Y., Iwasaki T., Hatano M., Hashimoto H., Baba Y. A quantum thermometric sensing and analysis system using fluorescent nanodiamonds for the evaluation of the living stem cell function according to intracellular temperature, Nanoscale Adv. 2020; 2: 1859-1868. Inside front cover
  2. Nishinaga Y., *Sato K., Yasui H., Taki S., Takahashi K., Shimizu M., Endo R., Koike C., Kuramoto N., Nakamura S., Fukui T., Yukawa H., Baba Y., Kaneko M. K., Chen-Yoshikawa T. F., Kobayashi H., Kato Y., Hasegawa Y. Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin, Cells 2020; 9(4): E1019.
  3. Murata Y., Jo J., Yukawa H., Tsumaki N., Baba Y., *Tabata Y. Visualization of Human Induced Pluripotent Stem Cells-Derived Three-Dimensional Cartilage Tissue by Gelatin Nanospheres, Tissue Eng. Part C Methods 2020; 26(5): 244-252.
  4. Fujiwara M., Sun S., Dohms A., Nishimura Y., Suto K., Takezawa Y., Oshimi K., Zhao L., Sadzak N., Umehara Y., Teki Y., Komatsu N., Benson O., Shikano Y., Kage-Nakadai E. Real-time nanodiamond thermometry probing in vivo thermogenic responses, Sci. Adv. 2020; 6: 9636.
  5. Fujiwara M., Dohms A., Suto K., Nishimura Y., Oshimi K., Teki Y., Cai K., Benson O., Shikano Y. Real-time estimation of the optically detected magnetic resonance shift in diamond quantum thermometry toward biological applications, Phys. Rev. Research 2020; 2: 043415.
  6. Kameyama T., Yamauchi H., Yamamoto H., Mizumaki T., Yukawa H., Yamamoto M., Ikeda S., Uematsu T., Baba Y., Kuwabata S., *Torimoto T. Tailored photoluminescence properties of Ag(In, Ga)Se2 quantum dots for near-infrared in vivo imaging, ACS Appl. Nano Mater. 2020; 3(4): 3275-3287. Front Cover
  7. Isobe Y., *Sato K., Nishinaga Y., Takahashi K., Taki S., Yasui H., Shimizu M., Endo R., Koike C., Kuramoto N., Yukawa H., Nakamura S., Fukui T., Kawaguchi K., Chen-Yoshikawa T.F., Baba Y., Hasegawa Y. Near-infrared photoimmunotherapy targeting DLL3 for small cell lung cancer, eBioMedicine 2020; 52: 102632.
  8. Kitase Y., *Sato Y., Ueda K., Suzuki T., Mikrogeorgiou A., Sugiyama Y., Matsubara K., Tsukagoshi Okabe Y., Shimizu S., Hirata H., Yukawa H., Baba Y., Tsuji M., Takahashi Y., Yamamoto A., Hayakawa M. A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats, Stem Cells Dev. 2020; 29(2): 63-74. Front Cover
Institute for Quantum Life Science