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Institute for Quantum Life Science

Quantum Regenerative and Biomedical Engineering Team

Update:2024年1月24日更新
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量子再生タイトル

量子再生概要図In regenerative medicine, there is concern that the differences of cellular states of stem cells and regenerated cells affect the regenerative functions such as the production of regeneration factors, differentiation ability, homing ability, and sensing ability. In this team, we aim to develop the measurement technology of cell statement of stem cells and regenerative cells by quantum nano censer such as nitrogen vacancy center fluorescent nano-diamonds (NVC nano-diamonds) for regenerative function diagnostics. NVC nano-diamonds is known to be able to measure and detect the temperature and pH concentration in the surrounding environment. In recent years, NVC nano-diamonds have been applied for the measurement of cellular temperature and pH concentration in mainly cancer cells such as HeLa cells. However, little is known about the application of NVC nano-diamonds for the measurement of cellular states of stem cells and regenerative cells. In this team, we newly develop the measurement technology of cellular state of stem cells, regenerative cells, matured cells existed in spheroids by NVC nano-diamonds for regenerative function diagnostics. We then elucidate the correlation between the cellular state of stem cells or regenerative cells and the regenerative function using this technology. In addition, we establish the technology that can detect and measure the cellular temperature, flexibility, and pH concentration of transplanted stem cells and regenerated cells in vivo or intra vital of mice.

Team Leader, Hiroshi Yukawa

Publications

2023

  1. Shimada T., Ueda Y., Takemaru H., Baba Y., *Yukawa H., Nano-quantum sensors-based imaging and sensing for target-based drug discovery and development. Trends Analyt. Chem., 2023 in press. 
  2. Shimada T., Fujino K., Yasui T., Kaji N., Ueda Y., Fujii K., Yukawa H., Baba Y., Resistive pulse sensing on a capillary-assisted microfluidic plat-form for on-site single particle analyses. Anal. Chem., 2023; 95(50):18335-18343.
  3. * Agetsuma M., Sato I., Tanaka Y., Carrillo-Reid L., Kasai A., Noritake A., Arai Y., Yoshitomo M., Inagaki T., Yukawa H., Hashimoto H., Nabekura J., Nagai T. Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation. Nat. Commun., 2023; 14(1): 5996.
  4. Tanoue Y., Tsuchiya T., Miyazaki T., Iwatake M., Watanabe H., Yukawa H., Sato K., Hatachi G., Shimoyama K., Matsumoto K., Doi R., Tomoshige K., Nagayasu T. Cell Transplant. 2023; 32: 09636897231207177.
  5. Matsuoka K., Mizuki Yamada M., Fukatsu N., Goto K., Shimizu M., Kato A., KatoY., Yukawa Y., Baba Y., Sato M., Sato K. Contrast-enhanced ultrasound imaging for monitoring the efficacy of near-infrared photoimmunotherapy. EBioMedicine, 2023; 104737. 
  6. Mizoguchi S., Tsuchiya T., Doi R., Obata T., Iwatake M., Matsumoto H., Yukawa H., Hayashi H., Li T.S., Yamamoto K., Matsumoto K., Miyazaki T., Tomoshige K., Nagayasu T. A novel ex vivo lung cancer model based on bioengineered rat lungs. Front. Bioeng. Biotechnol., 2023; 11: 1179830.
  7. Hisanaga M., Tsuchiya T., Watanabe H., Shimoyama K., Iwatake M., Tanoue Y., Maruyama K., Yukawa H., Sato K., Kato Y., Matsumoto K., Miyazaki T., Doi R., Tomoshige K., Nagayasu T. Adipose-Derived Mesenchymal Stem Cells Attenuate Immune Reactions Against Pig Decellularized Bronchi Engrafted into Rat Tracheal Defects. Organogenesis, 2023; 19(1): 2212582.
  8. *Yukawa H., Sato K., *Baba Y. Theranostics applications of quantum dots in regenerative medicine, cancer medicine, and infectious diseases, Adv. Drug. Deliv. Rev., 2023, 200: 114863.  Front Cover.
  9. Yamada S., *Yukawa H., Yoshizumi Y., Kitamura K., Mizumaki T., Oohara T., Nanizawa E., Hirano F., Sato K., Ishikawa T., Baba Y. In vivo real-time fluorescence imaging using quantum dots reveals the dynamics of transplanted stem cells in different inflammatory states of acute liver failure mice, Cell Transplant., 2023; 32: 1-11. 
  10. *Onoshima D., Sato R., Yukawa H., Nohira K., Min H., Baba Y. Development of Sampling and Measurement Technology for Indoor Particulate Matter Using a Small Drone, Earozoru Kenkyu, 2023; 38(1): 30-32.
  11. †Yoshida M., †Yukawa H., Hayashi K., Naitoh I., Miyabe K., Hori Y., Natsume M., Jinno N., Kato A., Kachi K., Asano G., Sahashi H., Toyohara Y., Kuno K., Kito Y., Kondo H., Hirano A., Okumura F., Anbe K., Baba Y., Kataoka H., *Tanaka Y. Clinical impact of bile-derived exosomal miRNAs as novel diagnostic and prognostic biomarkers for biliary tract cancers. Cancer Sci., 2023; 114(1), 295-305.         †Both authors contributed equally to this work. 

2022

  1. Minchuan, L., *Yukawa, H., Baba, Y., “Micro/Nano-fluidic devices and in vivo fluorescence imaging based on quantum dots for cytologic diagnosis,” Lab on a Chip 22, 2223-2236 (2022). Front Cover
  2. Oshimi, K., Nishimura, Y., Matsubara, T., Tanaka, M., Shikoh, E., Zhao, L., Zou, Y., Komatsu, N., Ikado, Y., Takezawa, Y., Kage-Nakadai, E., Izutsu, Y., Yoshizato, K., Morita, S., Tokunaga, M., Yukawa, H., Baba, Y., Teki, Y., *Fujiwara, M., “Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples,” Lab on a Chip 22, 2519-2530 (2022). Back Cover, Hot Article in 2022.
  3. Minchuan, L., *Yukawa, H., *Baba, Y., “Fluorescent/magnetic nano-aggregation via electrostatic force between modified quantum dot and iron oxide nanoparticles for bimodal imaging of U87MG tumor cells,” Anal. Sci. 38, 1141-1147 (2022). Front Cover, Hot Article in 2022.
  4. Minchuan, L., *Yukawa, H., Sato, K., Tozawa, M., Tokunaga, M., Kameyama, T., Torimoto, T., *Baba, Y., “Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of Targeted Tumors,” ACS Appl. Mater. Interfaces 14(30), 34365–34376 (2022).
  5. Yamada, S., *Yukawa, H., Yamada, K., Murata, Y., Jo, J., Yamamoto, M., Sugawara-Narutaki, A., Tabata, Y., Baba, Y., “In vivo multimodal imaging of stem cells using nanohybrid particles incorporating quantum dots and magnetic nanoparticles,” Sensors 22(15), 5705 (2022).
  6. *Takahashi, K., Yasui, H., Taki, S., Shimizu, M., Koike, C., Taki, K., Yukawa, H., Baba, Y., Kobayashi, H., *Sato, K., “Near-infrared-induced drug release from antibody–drug double conjugates exerts a cytotoxic photo-bystander effect,” Bioeng. Transl. Med. 7(3), e10388.
  7. †Yoshida, M., †Yukawa, H., Hayashi, K., Naitoh, I., Miyabe, K., Hori, Y., Natsume, M., Jinno, N., Kato, A., Kachi, K., Asano, G., Sahashi, H., Toyohara, Y., Kuno, K., Kito, Y., Kondo, H., Hirano, A., Okumura, F., Anbe, K., Baba, Y., Kataoka, H., *Tanaka, Y., “Clinical impact of bile-derived exosomal miRNAs as novel diagnostic and prognostic biomarkers for biliary tract cancers,” Cancer Sci. 114(1), 295-305 (2022). †Equal contribution.
  8. Tabata, H., Sasaki, M., Agetsuma, M., Sano, H., Hirota, Y., Miyajima, M., Hayashi, K., Honda, T., Nishikawa, M., Inaguma, Y., Ito, H., Takebayashi, H., Ema, M., Ikenaka, K., Nabekura, J., Nagata, K., Nakajima, K., “Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex,” Nat. Commun. 13(1), 6571 (2022).
  9. Onoshima, D., Hase, T., Kihara, N., Kuboyama, D., Tanaka, H., Ozawa, N., Yukawa, H., Sato, M., Ishikawa, K., Hasegawa, Y., Ishii, M., Hori, M., Baba, Y., “Leukocyte depletion and size-based enrichment of circulating tumor cells using a pressure-sensing microfiltration device,” ACS Meas. Sci Au 3(2), 113-119 (2022).
  10. Nakase, I., Miyai, M., Noguchi, K., Tamura, M., Yamamoto, Y., Nishimura, Y., Omura, M., Hayashi, K., Futaki, S., Tokonami, S., Iida, T., “Light-Induced Condensation of Biofunctional Molecules around Targeted Living Cells to Accelerate Cytosolic Delivery,” Nano Lett. 22(24), 9805-9814 (2022).

2021

  1. Nishimura, Y., Oshimi, K., Umehara, Y., Kumon, Y., Miyaji, K., Yukawa, H., Shikano, Y., Matsubara, T., *Fujiwara, M., Baba, Y., Teki, Y. “Wide-field fluorescent nanodiamond spin measurements toward real-time large-area intracellular thermometry,” Sci. Rep. 11(1), 4248 (2021).
  2. *Yukawa, H., Yamazaki, S., Aoki, K., Muto, K., Kihara, N., Sato, K., Onoshima, D., Ochiya, T., Tanaka, Y., *Baba, Y., “Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA,” Sci. Rep. 11(1), 8672 (2021).
  3. Rismaningsih, N., Yamauchi, H., Kameyama, T., Yamamoto, T., Morita, S., Yukawa, H., Uematsu, T., Baba, Y., Kuwabata, S., Torimoto, T. “Photoluminescence properties of quinary Ag–(In,Ga)–(S,Se) quantum dots with a gradient alloy structure for in vivo bioimaging,” J. Mater. Chem. C 9(34), 12791-12801 (2021).

2020

  1. *Yukawa, H., *Fujiwara, M., Kobayashi, K., Miyaji, K., Kumon, Y., Nishimura, Y., Oshimi, K., Umehara, Y., Teki, Y., Iwasaki, T., Hatano, M., Hashimoto, H., Baba, Y. “A quantum thermometric sensing and analysis system using fluorescent nanodiamonds for the evaluation of the living stem cell function according to intracellular temperature,” Nanoscale Adv. 2, 1859-1868 (2020). Inside front cover
  2. Nishinaga, Y., *Sato, K., Yasui, H., Taki, S., Takahashi, K., Shimizu, M., Endo, R., Koike, C., Kuramoto, N., Nakamura, S., Fukui, T., Yukawa, H., Baba, Y., Kaneko, M. K., Chen-Yoshikawa, T. F., Kobayashi, H., Kato, Y., Hasegawa, Y. “Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin,” Cells 9(4), E1019 (2020).
  3. Murata, Y., Jo, J. I., Yukawa, H., Tsumaki, N., Baba, Y., *Tabata, Y. “Visualization of Human Induced Pluripotent Stem Cells-Derived Three-Dimensional Cartilage Tissue by Gelatin Nanospheres,” Tissue Eng. Part C Methods 26(5), 244-252 (2020).
  4. Fujiwara, M., Sun, S., Dohms, A., Nishimura, Y., Suto, K., Takezawa, Y., Oshimi, K., Zhao, L., Sadzak, N., Umehara, Y., Teki, Y., Komatsu, N., Benson, O., Shikano, Y., Kage-Nakadai, E., “Real-time nanodiamond thermometry probing in vivo thermogenic responses”, Sci. Adv. 6, 9636 (2020).
  5. Fujiwara, M., Dohms, A., Suto, K., Nishimura, Y., Oshimi, K., Teki, Y., Cai, K., Benson, O., Shikano, Y., “Real-time estimation of the optically detected magnetic resonance shift in diamond quantum thermometry toward biological applications”, Phys. Rev. Research 2, 043415 (2020).
  6. Kameyama T., Yamauchi H., Yamamoto H., Mizumaki T., Yukawa H., Yamamoto M., Ikeda S., Uematsu T., Baba Y., Kuwabata S., *Torimoto T. Tailored photoluminescence properties of Ag(In, Ga)Se2 quantum dots for near-infrared in vivo imaging. ACS Appl. Nano Mater. 2020; 3(4), 3275-3287 (2020). Front Cover
  7. Isobe Y., *Sato K., Nishinaga Y., Takahashi K., Taki S., Yasui H., Shimizu M., Endo R., Koike C., Kuramoto N., Yukawa H., Nakamura S., Fukui T., Kawaguchi K., Chen-Yoshikawa T.F., Baba Y., Hasegawa Y. Near-infrared photoimmunotherapy targeting DLL3 for small cell lung cancer. EBioMedicine 52, 102632 (2020).
  8. Kitase Y., *Sato Y., Ueda K., Suzuki T., Mikrogeorgiou A., Sugiyama Y., Matsubara K., Tsukagoshi Okabe Y., Shimizu S., Hirata H., Yukawa H., Baba Y., Tsuji M., Takahashi Y., Yamamoto A., Hayakawa M. A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats. Stem Cells Dev. 29(2), 63-74 (2020). Front Cover