The various components of the brain, such as neurons, glia and blood vessels, support each other to maintain homeostasis. Applying quantum measurement technology (Nano quantum sensors), our goal is to clarify the complex interrelationship between the components that maintains brain health. Furthermore, we aim to understand the pathophysiology of brain disease when the interrelationship breaks down. It is expected that this knowledge can be utilized in the development of diagnostic and therapeutic methods for many brain diseases.
Team Leader, Hiroyuki Takuwa
Recent Publications
- Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model. Kudo T, Takuwa H, Takahashi M, Urushihata T, Shimojo M, Sampei K, Yamanaka M, Tomita Y, Sahara N, Suhara T, Higuchi M. iScience. 2023 Mar 5;26(4):106342
- Capillary responses to functional and pathological activations rely on the capillary states at rest. Suzuki H, Takeda H, Takuwa H, Ji B, Higuchi M, Kanno I, Masamoto K. J Cereb Blood Flow Metab. 2023 Jun;43(6):1010-1024.
- Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion. Urushihata T, Takuwa H, Takahashi M, Kershaw J, Shibata S, Nitta N, Tachibana Y, Yasui M, Higuchi M, Obata T. Front Neurosci. 2023 Jan 6;16:1071272.
- Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock in mice. Tachida Y, Miura S, Muto Y, Takuwa H, Sahara N, Shindo A, Matsuba Y, Saito T, Taniguchi N, Kawaguchi Y, Tomimoto H, Saido T, Kitazume S.J Biol Chem. 2022 Jun;298(6):101880.