Environmental factors including aging and stress etc. cause not only autoimmune diseases such as rheumatoid arthritis, but also chronic inflammatory diseases such as cerebrovascular disorders, cardiovascular disorders, and dementia that are inevitable in the modern aging society. Our previous studies have shown that chronic inflammation occurs when pathogenic immune cells including T cells and B cells locally induce microinflammation around specific blood vessels and break through the blood vessels to invade various organs and tissues. However, there is no preventive measure to detect and eliminate the microinflammation that causes the diseases at an early stage. In order to solve this problem, we will visualize the location of microinflammation using a high-sensitivity quantum technics (see picture below) and clarify how chronic inflammation begins and progresses so that we can eliminate them by using drugs as well as neuromodulation technics.
Team Leader, Masaaki Murakami
Members
Masaaki Murakami (Team Leader)
Yuki Tanaka（Visiting Researcher）
Shintaro Hojyo（Visiting Researcher）
Shimpei Kubota（Visiting Researcher）
Kazuki Tainaka（Visiting Researcher）
Recent Publications
2023
12.
Hiroki Tanaka, Rie Hasebe, Kaoru Murakami, Toshiki Sugawara, Takeshi Yamasaki, Masaaki Murakami, Gateway Reflexes describe novel neuro-immune communications that establish immune cell gateways at specific vessels, Bioelectronic Medicine, in press
11.
Kaoru Murakami, Shimpei Kubota, Kumiko Tanaka, Hiroki Tanaka, Keiichiroh Akabane, Rigel Suzuki, Yuta Shinohara, Hiroyasu Takei, Shigeru Hashimoto, Yuki Tanaka, Shintaro Hojyo, Osamu Sakamoto, Norihiko Naono, Takayui Takaai, Kazuki Sato, Yuichi Kojima, Toshiyuki Harada, Takeshi Hattori, Satoshi Fuke, Isao Yokota, Satoshi Konno, Takashi Washio, Takasuke Fukuhara, Takanori Teshima, Masateru Taniguchi, and Masaaki Murakami, High-Precision Rapid Testing of Omicron SARS-CoV-2 Variants in Clinical Samples Using AI-Nanopore, Lab on a Chip, 2023 October 25
10.
Hideaki Shiraishi, Kiyoshi Egawa, Kaoru Murakami, Yuki Ueda, Midori Nakajima, Sachiko Nakakubo, Masashi Narugami, Shuhei Kimura, Takeru Goto, Yasuyoshi Hiramatsu, and Masaaki Murakami, Transcutaneous Auricular Vagus Nerve Stimulation Therapy in Patients with Cognitively Preserved Structural Focal Epilepsy, Brain and Development, 2023 August
9.
Yong Bin Teoh, Jing-Jing Jiang, Takeshi Yamasaki, Noriyuki Nagata, Toshiki Sugawara, Rie Hasebe, Hiroshi Ohta, Noboru Sasaki, Nozomu Yokoyama, Kensuke Nakamura, Yumiko Kagawa, Mitsuyoshi Takiguchi, and Masaaki Murakami, An inflammatory bowel disease-associated SNP increases local thyroglobulin expression to develop inflammation in Miniature Dachshunds, Frontiers in Veterinary Science, in press
8.
Keiichiroh Akabane, Kaoru Murakami, Masaaki Murakami, Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation, Expert Opinion on Therapeutic Targets, 2023 June 20
7.
Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto, Seiichiro Naito, Yuki Tanaka, Izuru Ohki, Yuta Shinohara, Norimasa Iwasaki, Akihiko Yoshimura, Jing-Jing Jiang, Daisuke Kamimura, Shintaro Hojyo, Shimpei I. Kubota, Shigeru Hashimoto, and Masaaki Murakami, Computer simulation of an IL-6 dependent rheumatoid arthritis model in F759 mice, Int Immunol., 2023 May 25
6.
Shiina Matsuyama, Reiji Yamamoto, Kaoru Murakami, Nobuhiko Takahashi, Rieko Nishi, Asuka Ishii, Junko Kobayashi, Nobuya Abe, Kumiko Tanaka, Jing-Jing Jiang, Tadafumi Kawamoto, Toshihiko Iwanaga, Yuta Shinohara, Takeshi Yamasaki, Izuru Ohki, Shintaro Hojyo, Rie Hasebe, Shimpei Kubota, Noriyuki Hirata, Daisuke Kamimura, Shigeru Hashimoto, Yuki Tanaka, and, Masaaki Murakami, GM-CSF promotes the survival of peripheral-derived myeloid cells in the CNS for pain-induced relapse of neuroinflammation, Journal of Immunology, in press
5.
Hajime Senjo, Shinpei Harada, Shimpei Kubota, Yuki Tanaka, Takahiro Tateno, Zixuan Zhang, Satomi Okada, Xuanzhong Chen, Ryo Kikuchi, Naoki Miyashita, Masahiro Onozawa, Hideki Goto, Tomoyuki Endo, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Masaaki Murakami, Takanori Teshima, and Daigo Hashimoto, Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT, Blood, in press
4.
Hiroaki Kida, Jing-Jing Jiang, Yuichiro Matsui, Ikuko Takahashi, Rie Hasebe, Makoto Kondoh, Yasuhiko Nishio, Kinya Nishida, Yoshihiro Matsuno, Tsukasa Oikawa, Shimpei Kubota, Shintaro Hojyo, Norimasa Iwasaki, Shigeru Hashimoto, Yuki Tanaka, and Masaaki Murakami, Dupuytren’s contracture-associated SNPs increase SFRP4 expression in nonimmune cells including fibroblasts to enhance inflammation development, Int Immunol., 31 January 2023, doi:10.1093/intimm/dxad004
3.
Takeshi Yamasaki, Noriyuki Nagata, Toru Atsumi, Rie Hasebe, Yuki Tanaka, Izuru Ohki, Shimpei Kubota, Yuta Shinohara, Yong Bin Teoh, Nozomu Yokoyama, Noboru Sasaki, Kensuke Nakamura, Hiroshi Ohta, Takehiko Katsurada, Yoshihiro Matsuno, Shintaro Hojyo, Shigeru Hashimoto, Mitsuyoshi Takiguchi, Masaaki Murakami, Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients, Int Immunol. 2023 Mar 18, doi: 10.1093/intimm/dxad006
2.
Fayrouz Naim, Rie Hasebe, Shintaro Hojyo, Yukatsu Shichibu, Asuka Ishii, Yuki Tanaka, Kazuki Tainaka, Shimpei I. Kubota, Katsuaki Konishi and Masaaki Murakami, In situ Microinflammation Detection Using Gold Nanoclusters and a Tissue-clearing Method, bio-plotocol, Vol 13, Iss 7, Apr 5, 2023 DOI:10.21769/BioProtoc.4644
1.
Tianyue Zhai, Takashi Mitamura, Lei Wang, Shimpei I Kubota, Masaaki Murakami, Shinya Tanaka, Hidemichi Watari, Combination therapy with bevacizumab and CCR2 inhibitor for women with ovarian cancer: in vivo validation study, Cancer Medicine, 22 February 2023, doi:10.1002/cam4.5674
2022
8. Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, Hiromi Yamamoto, Shuhei Sakakibara, Chikako Ono, Yumi Itoh, Tommy Terooatea, Kazuo Yamashita, Toru Okamoto, Noritaka Hashii, Akiko Ishii-Watabe, Noah Butler, Yoshiharu Matsuura, Hisatake Matsumoto, Shinya Otsuka, Kei Hiraoka, Takanori Teshima, Masaaki Murakami, and Tomohiro Kurosaki, Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees, Journal of Experimental Medicine, 13 December 2022, doi:10.1084/jem.20221786, ()Article)
7. Nobuya Abe, Michihiro Kono, Michihito Kono , Takayuki Katsuyama, Kazumasa Ohmura, Taiki Sato, Kohei Karino, Yuichiro Fujieda, Masaru Kato, Rie Hasebe, Masaaki Murakami, Tatsuya Atsumi, Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis: a preliminary observational study, Frontiers in Immunology, doi:10.3389/fimmu.2022.1066916, ()Article)
6. Kaoru Murakami, Sumio Iwasaki, Satoshi Oguri, Kumiko Tanaka, Rigel Suzuki, Kasumi Hayasaka, Shinichi Fujisawa, Chiaki Watanabe, Satoshi Konno, Isao Yokota, Takasuke Fukuhara, Masaaki Murakami, Takanori Teshimach, SARS-CoV-2 Omicron detection by antigen tests using saliva, Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100109, ()Article)
5. Nobuya Abe, Masato Tarumi, Yuichiro Fujieda, Nobuhiko Takahashi, Kohei Karino, Mona Uchida, Michihito Kono, Yuki Tanaka, Rie Hasebe, Masaru Kato, Olga Amengual, Yoshiyuki Arinuma, Kenji Oku, Wakiro Sato, Khin Khin Tha, Miwako Yamasaki, Masahiko Watanabe, Tatsuya Atsumi, Masaaki Murakami, Pathogenic neuropsychiatric effect of stress-induced microglial interleukin 12/23 axis in systemic lupus erythematosus, Ann. Rheum. Dis., doi:10.1136/ard-2022-222566, () (ArticleHYPERLINK "https://www.igm.hokudai.ac.jp/neuroimmune/files/Abe_N_Ann_Rheum_Dis_2022.pdf" )
4. Nobuya Abe, Michihito Kono, Michihiro Kono, Naoki Ohnishi, Tomoya Sato, Masato Tarumi, Masaru Yoshimura, Taiki Sato, Kohei Karino, Yuka Shimizu, Yuichiro Fujieda, Masaru Kato, Rie Hasebe, Kenji Oku, Masaaki Murakami, Tatsuya Atsumi. Glycogen synthase kinase 3β/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO, British Journal of Haematology. 2022. 196(5):1194-1204.
3. Takashi Kudo, Daigo Nakazawa, Kanako Watanabe-Kusunoki, Masatoshi Kanda, Satoka Shiratori-Aso, Nobuya Abe, Saori Nishio, Jun-Ichiro Koga, Sari Iwasaki, Takahiro Tsuji, Yuichiro Fukasawa, Miwako Yamasaki, Masahiko Watanabe, Sakiko Masuda, Utano Tomaru, Masaaki Murakami, Yasuaki Aratani, Akihiro Ishizu, Tatsuya Atsumi, Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody–Associated Vasculitis, Arthritis & Rheumatology, 29 July 2022, doi: 10.1002/art.42314()Article)
2. Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa, Fuminori Kawano, Yoshinobu Ohira, Tadafumi Kawamoto, Fiona E. Yull, Timothy S. Blackwell, Junko Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, Nobuhiro Watanabe, Harumi Hotta, Toshihide Yamashita, Daisuke Kamimura, Yuki Tanaka, Masaaki Murakam, ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons. J. Exp. Med. May 2022, 219(6), doi: 10.1084/jem.20212019 ()Article)
1. Kevin J Tracey, Sangeeta Chavan, Masaaki Murakami, Introduction: Electronic Medicine in Immunology Special Issue Part 2, Int. Immunol., 29 July 2022, doi: 10.1093/intimm/dxab100 ()Article)
Moonshot Goal 7 : Program
Please click the URL below, and you will find the video files of the Moonshot Goal 7 Program Introduction on YouTube.
long (8 min)： Moonshot Goal 7 : Program（long）
medium (3 min)：Moonshot Goal 7 : Program（medium）
short (1 min)：Moonshot Goal 7 : Program（short）