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Institute for Quantum Life Science

Quantum RedOx Chemistry Team

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Redox means reduction and oxidation reactions, in which the transfer of electrons, hydrogen atoms, or hydride ions occurs, and plays a pivotal role in biological reactions, such as photosynthesis, cell respiration and so on. Our research group aims to elucidate the mechanisms for bio-related redox reactions, especially for generating and scavenging of reactive oxygen species and related radicals at molecular and quantum levels, using physicochemical techniques.







Team Leader, Ikuo Nakanishi



  1. Kohzuki, H.; Ito H.; Kurokawa, H.; Matsui, H.; Yamamoto, T.; Ishikawa, E. Reactive Oxygen Species Induced by Indomethacin Enhance Accumulation of Heme Carrier Protein 1 and Hematoporphyrin Accumulation In Vitro and In Vivo in a Brain Tumor Model. J. Clin. Biochem. Nutr. in press.
  2. Masuda, D.; Nakanishi, I.; Ohkubo, K.; Ito, H.; Matsumoto, K.; Ichikawa, H.; Chatatikun, M.; Klangbud, W. K.; Kotepui, M.; Imai, M.; Kawakami, F.; Kubo, M.; Matsui, H.; Tangpong, J.; Ichikawa, T.; Ozawa, T.; Yen, H.-C.; St Clair, D. K.; Indo, H. P.; Majima, H. J. Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress-Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol? Biomolecules 2024, 14, 128.
  3. Kawabata, Y.; Fukushige, T.; Indo, H. P.; Matsumoto, K.; Ueno, M.; Nakanishi, I.; Chatatikun, M.; Klangbud, W. K.; Surinkaew, S.; Tangpong, J.; Kanekura, T.; Majima, H. J. Hair Follicle Damage after 100 mGy Low-Dose Fractionated X-Ray Irradiation and the Protective Effects of TEMPOL, a Stable Nitroxide Radical, against Radiation, Radiat. Res. 2024, 201, 115-125.
  4. Ito, H.; Shoji, Y.; Matsumoto, K.; Fukuhara, K.; Nakanishi, I. Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog. ACS Med. Chem. Lett. 2024, 15, 310-313.
  5. Ikeda, T.; Kurokawa, H.; Ito, H.; Tsuchiya, K.; Matsui, H. Enhancement of Cytotoxic Effects with ALA-PDT on Treatment of Radioresistant Cancer Cells. J. Clin. Biochem. Nutr. 2024, 74, 17-21.
  6. Ito, H.; Shoji, Y.; Ueno, M.; Matsumoto, K.; Nakanishi, I. Photodynamic Therapy for X-ray-Induced Radiation-Resistant Cancer Cells. Pharmaceutics 2023, 15, 2536.
  7. Ito, H.; Shoji, Y.; Matsumoto, K.; Fukuhara, K.; Nakanishi, I. Anti-Cancer Effect of a Planar Catechin Analog through the Decrease in Mitochondrial Membrane Potential. ACS Med. Chem. Lett. 2023, 14, 1478-1481.
  8. Nakanishi, I.; Shoji, Y.; Ohkubo, K.; Ito, H.; Fukuzumi, S. Water-Induced Regeneration of a 2,2-Diphenyl-1-picrylhydrazyl Radical after Its Scandium Ion-Promoted Electron-Transfer Disproportionation in an Aprotic Medium. Molecules 2023, 28, 5002.
  9. Manda, K.; Ohkubo, K.; Shoji, Y.; Zoardar, A. K. M. R. K.; Kamibayashi, M.; Ozawa, T.; Anzai, K.; Nakanishi, I. In Vitro Radical-Scavenging Mechanism of Melatonin and Its In Vivo Protective Effect against Radiation-Induced Lipid Peroxidation. Redox Biochem. Chem. 2023, 3-4, 100003.


  1. Ueno, M.; Parajuri, R. K.; Ito, H.; Iiyama, M.; Suzuki, S.; Matsumoto, K.; Nakanishi, I.; Aoki, I.; Sumiyoshi, A. Effects of X-ray Irradiation on the Redox Status in the Colorectum Tissue of Mouse. Adv. Redox Res. 20238, 100067.
  2. Indo, H. P.; Masuda, D.; Srburee, S.; Ito H.; Nakanishi, I.; Matsumoto, K.; Mankhetkorn, S.; Chatatikun, M.; Surinkaew, S.; Udomwech, L.; Kawami, F.; Ichikawa, T.; Matsui, H.; Tangpong, J.; Majima, H. J. Evidence of Nrf2/Keap 1 Signaling Regulation by Mitochondria-Generated Reactive Oxygen Species in RGK1 Cells. Biomolecules 202313, 445.
  3. Fukuhara, K.; Nakanishi, I.; Imai, K.; Mizuno, M.; Matsumoto, K.; Ohno, A. DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination. Antioxidants 202312, 225.
  4. Ueno, M.; Shibata, S.; Nakanishi, I.; Aoki, I.; Yamada, K.; Matsumoto, K. Effects of Selenium Deficiency on Biological Results of X-ray and Carbon-Ion Beam Irradiation in Mice. J. Clin. Biochem. Nutr. 202372, 107-116.
  5. Kurokawa, H.; Ito, H.; Matano, D.; Terasaki, M.; Matsui, H. Acetic Acid Enhances the Effect of Photodynamic Therapy in Gastric Cancer Cells via the Production of Reactive Oxygen Species. J. Clin. Biochem. Nutr. 202271, 206-211.
  6. Igarashi, K.; Shoji, Y.; Sekine-Suzuki, E.; Ueno, M.; Matsumoto, K.; Nakanishi, I.; Fukui, K. Importance of Locations of Iron Ions to Elicit Cytotoxicity Induced by a Fenton-Type Reaction. Cancers 202214, 3642.


  1. Nakanishi, I.; Shoji, Y.; Ohkubo, K.; Ueno, M.; Shimoda, K.; Matsumoto, K.; Fukuhara, K.; Hamada, H. Effect of Magnesium Ion on the Radical-Scavenging Rate of Pterostilbene in an Aprotic Medium: Mechanistic Insight into the Antioxidative Reaction of Pterostilbene. Antioxidants 202211, 340.
  2. Matsumoto, K.; Ueno, M.; Shoji, Y.; Nakanishi, I. Estimation of the Local Concentration of the Markedly Dense Hydroxyl Radical Generation Induced by X-rays in Water. Molecules 202227, 592.
  3. Makino, Y.; Ueno, M.; Shoji, Y.; Nyui, M.; Nakanishi, I.; Fukui, K.; Matsumoto, K. Simplifying Quantitative Measurement of Free Radical Species Using an X-Band EPR Spectrometer. J. Clin. Biochem. Nutr. 202270, 213-221.
  4. Nakanishi, I.; Shoji, Y., Electrochemical Redox Behavior of 2,2-Diphenyl-1-picrylhydrazyl Radical Solubilized by beta-Cyclodextrin in Water. Electrochem. Commun. 2022134, 107190.
  5. Nakanishi, I.; Shoji, Y.; Ohkubo, K.; Fukuzumi, S. Tunneling in the Hydrogen-Transfer Reaction from a Vitamin E Analog to an Inclusion Complex of 2,2-Diphenyl-1-picrylhydrazyl Radical with beta-Cyclodextrin in an Aqueous Buffer Solution at Ambient Temperature. Antioxidants 202110, 1966.
  6. Matsumoto, K.; Nakanishi, I.; Abe, Y.; Sato, S.; Kohno, R.; Sakata, D.; Mizushima, K.; Lee, S. H.; Inaniwa, T. Effects of Loading a Magnetic Field Longitudinal to the Linear Particle-Beam Track on Yields of Reactive Oxygen Species in Water. Free Radical Res. 202155, 547-555. (2021)
  7. Matsumoto, K.; Ueno, M.; Nyui, M.; Shoji, Y.; Nakanishi, I. Effects of LET on Oxygen-Dependent and -Independent Generation of Hydrogen Peroxide in Water Irradiated by Carbon-Ion Beams. Free Radical Res. 202155, 589-594.
  8. Matsumoto, K.; Nakanishi, I.; Zhelev, Z.; Bakalova, R.; Aoki, I. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Imaging. Antioxid. Redox Signaling 202236, 95-121.
  9. Yogo, K.; Murayama, C.; Hirayama, R.; Matsumoto, K.; Nakanishi, I.; Ishiyama, H.; Yasuda, H. Protective Effects of Amino Acids on Plasmid DNA Damage Induced by Therapeutic Carbon Ions. Radiat. Res. 2021196, 197-203.