Current
Home > Institute for Quantum Life Science > Quantum RedOx Chemistry Team

Institute for Quantum Life Science

Quantum RedOx Chemistry Team

Update：2025年4月1日更新
Display printing page

レドックスタイトル

量子レドックス化学研究G図

Redox means reduction and oxidation reactions, in which the transfer of electrons, hydrogen atoms, or hydride ions occurs, and plays a pivotal role in biological reactions, such as photosynthesis, cell respiration and so on. Our research group aims to elucidate the mechanisms for bio-related redox reactions, especially for generating and scavenging of reactive oxygen species and related radicals at molecular and quantum levels, using physicochemical techniques.

中西チームリーダー

 

 

 

 

 

Team Leader, Ikuo Nakanishi

​

Publications

2024

  1. Hirano, H.; Nagata, A.; Marumo, K.; Takahashi, H.; Nakanishi, I.; Kawai, A. Radical Scavenging Rate Constants Determined by Spin Relaxation Times of Spin Polarized Radicals as Measured by Free Induction Decay Signals. J. Chem. Phys. 2025, 162, 124707.
  2. Abe, H.; Indo, H. P.; Ito H.; Majima, H. J.; Tanaka, T. Synephrine Inhibits Oxidative Stress and H2O2-Induced Premature Senescence. Cell Biochem. Biophys. 2025, 83, in press.
  3. Indo, H. P.; Chatatikun, M.; Nakanishi, I.; Matsumoto, K.; Imai, M.; Kawakami, F.; Kubo, M.; Abe, H.; Ichikawa, H.; Yonei, Y.; Beppu, H. J.; Minamiyama, Y.; Kanekura, T.; Ichikawa, T.; Phongphithakchai, A.; Udomwech, L.; Sukati, S.; Charong, N.; Somsak, V.; Tangpong, J.; Nomura, S.; Majima, H. J. The Roles of Mitchondria in Human Being's Life and Aging. Biomolecules, 2024, 14, 1317.
  4. Shimizu, W.; Shoji, Y.; Ohkubo, K.; Ito, H.; Nakanishi, I.; Fukuhara, K. Antioxidant Activity of Planar Catechin Conjugated with Trolox. Antioxidants 2024, 13, 1165.
  5. Ito, H.; Shoji, Y.; Matsumoto, K.; Fukuhara, K.; Nakanishi, I. A Mechanism for Apoptotic Effects of a Planar Catechin Analog on Cancer Cells. Molecules 2024, 29, 4467.
  6. Mori, R.; Abe, M.; Saimoto, Y.; Shinto, S.; Jodai, S.; Tomomatsu, M.; Tazoe, K.; Ishida, M.; Enoki, M.; Kato, N.; Yamashita, T.; Itabashi, Y.; Nakanishi, I.; Ohkubo, K.; Kaidzu, S.; Tanito, M.; Matsuoka, Y.; Morimoto, K.; Yamada, K. Construction of a Screening System for Lipid-Derived Radical Inhibitors and Validation of Hit Compounds to Target Retinal and Cerebrovascular Diseases. Redox Biol. 2024, 73, 103186.
  7. Shoji, Y.; Terashima, Y.; Ohkubo, K.; Ito, H.; Maruyama, K.; Fukuzumi, S.; Nakanishi, I. Scandium Ion-Promoted Electron-Transfer Disproportionation of 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO center dot) in Acetonitrile and Its Regeneration Induced by Water. Int. J. Mol. Sci. 2024, 25, 4417.

2023​

  1. Kohzuki, H.; Ito H.; Kurokawa, H.; Matsui, H.; Yamamoto, T.; Ishikawa, E. Reactive Oxygen Species Induced by Indomethacin Enhance Accumulation of Heme Carrier Protein 1 and Hematoporphyrin Accumulation In Vitro and In Vivo in a Brain Tumor Model. J. Clin. Biochem. Nutr. 2024, 74, 207-212.
  2. Masuda, D.; Nakanishi, I.; Ohkubo, K.; Ito, H.; Matsumoto, K.; Ichikawa, H.; Chatatikun, M.; Klangbud, W. K.; Kotepui, M.; Imai, M.; Kawakami, F.; Kubo, M.; Matsui, H.; Tangpong, J.; Ichikawa, T.; Ozawa, T.; Yen, H.-C.; St Clair, D. K.; Indo, H. P.; Majima, H. J. Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress-Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol? Biomolecules 2024, 14, 128.
  3. Kawabata, Y.; Fukushige, T.; Indo, H. P.; Matsumoto, K.; Ueno, M.; Nakanishi, I.; Chatatikun, M.; Klangbud, W. K.; Surinkaew, S.; Tangpong, J.; Kanekura, T.; Majima, H. J. Hair Follicle Damage after 100 mGy Low-Dose Fractionated X-Ray Irradiation and the Protective Effects of TEMPOL, a Stable Nitroxide Radical, against Radiation, Radiat. Res. 2024, 201, 115-125.
  4. Ito, H.; Shoji, Y.; Matsumoto, K.; Fukuhara, K.; Nakanishi, I. Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog. ACS Med. Chem. Lett. 2024, 15, 310-313.
  5. Ikeda, T.; Kurokawa, H.; Ito, H.; Tsuchiya, K.; Matsui, H. Enhancement of Cytotoxic Effects with ALA-PDT on Treatment of Radioresistant Cancer Cells. J. Clin. Biochem. Nutr. 2024, 74, 17-21.
  6. Ito, H.; Shoji, Y.; Ueno, M.; Matsumoto, K.; Nakanishi, I. Photodynamic Therapy for X-ray-Induced Radiation-Resistant Cancer Cells. Pharmaceutics 2023, 15, 2536.
  7. Ito, H.; Shoji, Y.; Matsumoto, K.; Fukuhara, K.; Nakanishi, I. Anti-Cancer Effect of a Planar Catechin Analog through the Decrease in Mitochondrial Membrane Potential. ACS Med. Chem. Lett. 2023, 14, 1478-1481.
  8. Nakanishi, I.; Shoji, Y.; Ohkubo, K.; Ito, H.; Fukuzumi, S. Water-Induced Regeneration of a 2,2-Diphenyl-1-picrylhydrazyl Radical after Its Scandium Ion-Promoted Electron-Transfer Disproportionation in an Aprotic Medium. Molecules 2023, 28, 5002.
  9. Manda, K.; Ohkubo, K.; Shoji, Y.; Zoardar, A. K. M. R. K.; Kamibayashi, M.; Ozawa, T.; Anzai, K.; Nakanishi, I. In Vitro Radical-Scavenging Mechanism of Melatonin and Its In Vivo Protective Effect against Radiation-Induced Lipid Peroxidation. Redox Biochem. Chem. 2023, 3-4, 100003.

2022

  1. Ueno, M.; Parajuri, R. K.; Ito, H.; Iiyama, M.; Suzuki, S.; Matsumoto, K.; Nakanishi, I.; Aoki, I.; Sumiyoshi, A. Effects of X-ray Irradiation on the Redox Status in the Colorectum Tissue of Mouse. Adv. Redox Res. 2023, 8, 100067.
  2. Indo, H. P.; Masuda, D.; Srburee, S.; Ito H.; Nakanishi, I.; Matsumoto, K.; Mankhetkorn, S.; Chatatikun, M.; Surinkaew, S.; Udomwech, L.; Kawami, F.; Ichikawa, T.; Matsui, H.; Tangpong, J.; Majima, H. J. Evidence of Nrf2/Keap 1 Signaling Regulation by Mitochondria-Generated Reactive Oxygen Species in RGK1 Cells. Biomolecules 2023, 13, 445.
  3. Fukuhara, K.; Nakanishi, I.; Imai, K.; Mizuno, M.; Matsumoto, K.; Ohno, A. DTPA-Bound Planar Catechin with Potent Antioxidant Activity Triggered by Fe3+ Coordination. Antioxidants 2023, 12, 225.
  4. Ueno, M.; Shibata, S.; Nakanishi, I.; Aoki, I.; Yamada, K.; Matsumoto, K. Effects of Selenium Deficiency on Biological Results of X-ray and Carbon-Ion Beam Irradiation in Mice. J. Clin. Biochem. Nutr. 2023, 72, 107-116.
  5. Kurokawa, H.; Ito, H.; Matano, D.; Terasaki, M.; Matsui, H. Acetic Acid Enhances the Effect of Photodynamic Therapy in Gastric Cancer Cells via the Production of Reactive Oxygen Species. J. Clin. Biochem. Nutr. 2022, 71, 206-211.
  6. Igarashi, K.; Shoji, Y.; Sekine-Suzuki, E.; Ueno, M.; Matsumoto, K.; Nakanishi, I.; Fukui, K. Importance of Locations of Iron Ions to Elicit Cytotoxicity Induced by a Fenton-Type Reaction. Cancers 2022, 14, 3642.

2021

  1. Nakanishi, I.; Shoji, Y.; Ohkubo, K.; Ueno, M.; Shimoda, K.; Matsumoto, K.; Fukuhara, K.; Hamada, H. Effect of Magnesium Ion on the Radical-Scavenging Rate of Pterostilbene in an Aprotic Medium: Mechanistic Insight into the Antioxidative Reaction of Pterostilbene. Antioxidants 2022, 11, 340.
  2. Matsumoto, K.; Ueno, M.; Shoji, Y.; Nakanishi, I. Estimation of the Local Concentration of the Markedly Dense Hydroxyl Radical Generation Induced by X-rays in Water. Molecules 2022, 27, 592.
  3. Makino, Y.; Ueno, M.; Shoji, Y.; Nyui, M.; Nakanishi, I.; Fukui, K.; Matsumoto, K. Simplifying Quantitative Measurement of Free Radical Species Using an X-Band EPR Spectrometer. J. Clin. Biochem. Nutr. 2022, 70, 213-221.
  4. Nakanishi, I.; Shoji, Y., Electrochemical Redox Behavior of 2,2-Diphenyl-1-picrylhydrazyl Radical Solubilized by beta-Cyclodextrin in Water. Electrochem. Commun. 2022, 134, 107190.
  5. Nakanishi, I.; Shoji, Y.; Ohkubo, K.; Fukuzumi, S. Tunneling in the Hydrogen-Transfer Reaction from a Vitamin E Analog to an Inclusion Complex of 2,2-Diphenyl-1-picrylhydrazyl Radical with beta-Cyclodextrin in an Aqueous Buffer Solution at Ambient Temperature. Antioxidants 2021, 10, 1966.
  6. Matsumoto, K.; Nakanishi, I.; Abe, Y.; Sato, S.; Kohno, R.; Sakata, D.; Mizushima, K.; Lee, S. H.; Inaniwa, T. Effects of Loading a Magnetic Field Longitudinal to the Linear Particle-Beam Track on Yields of Reactive Oxygen Species in Water. Free Radical Res. 2021, 55, 547-555. (2021)
  7. Matsumoto, K.; Ueno, M.; Nyui, M.; Shoji, Y.; Nakanishi, I. Effects of LET on Oxygen-Dependent and -Independent Generation of Hydrogen Peroxide in Water Irradiated by Carbon-Ion Beams. Free Radical Res. 2021, 55, 589-594.
  8. Matsumoto, K.; Nakanishi, I.; Zhelev, Z.; Bakalova, R.; Aoki, I. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Imaging. Antioxid. Redox Signaling 2022, 36, 95-121.
  9. Yogo, K.; Murayama, C.; Hirayama, R.; Matsumoto, K.; Nakanishi, I.; Ishiyama, H.; Yasuda, H. Protective Effects of Amino Acids on Plasmid DNA Damage Induced by Therapeutic Carbon Ions. Radiat. Res. 2021, 196, 197-203.
Institute for Quantum Life Science