Electronic Properties of Biomolecules and Life Science Team

To understand biological phenomena from the molecular level, such as DNA and proteins, to the micro and macro level, such as cells and tissues, from a quantum theoretical perspective, we aim to elucidate quantum mechanisms based on electronic state information obtained through synchrotron radiation spectroscopy and imaging experiments on biomolecules. We also actively develop technologies and theoretical calculations to conduct these experiments and analyses.

Team Leader, Kentaro Fujii

2024年度の成果

1. Y. Izumi*, R. Ugalino*, J. Miyawaki, C. Shibazaki, M. Adachi, N. Kurahashi, H. Kiuchi, Y. Harada, K. Fujii, Electronic structures of blue copper centers of amicyanin and azurin and solution state, Dalton Transactions 54 1980-1985 (2025) *: equal contribution
2. K. Fujii, Y. Izumi, N. Maita, M. Koichi M. Kato, Observation of the liquid-liquid phase separation of FUS-LC using vacuum-ultraviolet circular dichroism spectroscopy, Chrality, 36 e23707 (2024)
3. M-A Herve du Penhoat, A. Souchaud, A. Rajpal, R. Vuilleumier, M-P Gaigeot, I. Tavernelli, K. Fujii, A. Yokoya, S-DTendero, M-F Politis, Ultrafast Fragmentation of Highly-excited Doubly-ionized Deoxyribose: Role of the Liquid, Water Environment, PCCP 26 15693-15704 (2024)
4. S. Nakagawa, T. Maeyama, A. Yokoya, M. Ohara, N. Usami, Distribution of the dose response in a silicone-based radio-fluorogenic dosimeter and FWT-60 irradiated with monochromatic low-energy X-rays, Radiation Measurements, 181 107347 (2025)
5. W. Zhang, M. al Samarai, H. Zhao, D. Liu, H. Kiuchi, R. Ugalino, S. Li, F. Yao, Q. Feng, Y. Harada, Facet-dependent photocatalytic performance and electronic structure of single-crystalline anatase TiO2 particles revealed by X-ray photoelectron spectromicroscopy, Journal of Materials Chemistry C, 13 61-37 (2024)
6. 廣瀬エリ、横谷明徳、野口実穂、Lucie Huart、鈴木啓司, ゲノムの構造と機能、およびエネルギー代謝に及ぼす放射線の長期影響, 放射線生物研究 59 134-156 (2024)

2023年度の成果

1. K. Nishikubo, M. Hasegawa, Y. Izumi, K. Fujii , K. Matsuo, Y. Matsumoto, A. Yokoya, Structural study of wild-type and phospho-mimic XRCC4 dimer and multimer proteins using circular dichroism spectroscopy, Int. J. Radiat. Biol. 91684-1691 (2023)
2. M. Hirato, A. Yokoya, Y. Baba, S. Mori, K. Fujii, S. Wada, Y. Izumi, Incorporation of a bromine atom into DNA-related molecules changes their electronic properties, PCCP, 21 14836-14847 (2023)
3. Y. Izumi, M. Ohara, K. Fujii, A. Yokoya, M. Ogawa, X-ray irradiation-induced ligand cleavage of a phthalocyanine derivative, tin (IV) phthalocyanine dichloride: A potential for X-ray activation of caged compounds, Chem. Phys. Lett. 822 140508 (2023)

2022年度の成果

1. Y. Izumi, K. Matsuo, A. Yokoya, Secondary structural analyses of histone H2A-H2B proteins extracted from heated cells, Chirality 35・3 165-171 (2022).
2. H. Yu, Y. Kondo, K. Fujii, A. Yokoya, S. Yamashita, Establishment of a Method for Investigating Direct and Indirect Actions of Ionizing Radiation Using Scavenger-free Plasmid DNA, Radiat. Res. 197・6 594-604 (2022).
3. K. Horiba, T. Imazono, H. Iwasawa, K. Fujii, J. Miyawaki, Y. Ohtsubo, N. Inami, T. Nakatani, K. Inaba, A. Agui, H. Kimura, M. Takahashi, Design of nano-ARPES beamline at 3-GeV next-generation synchrotron radiation facility, NanoTerasu Journal of Physics: Conference Series. 2380 12034 (2022).
4. Y. Ohtsubo, T. Ueno, H. Iwasawa, J. Miyawaki, K. Horiba, A. Agui, K. Inaba, T. Nakatani, T. Imazono, K. Fujii, H. Kimura, M. Takahashi, Design for nano-spintronics beamline at 3-GeV next-generation synchrotron radiation facility, NanoTerasu Journal of Physics: Conference Series. 2380 12037 (2022).
5. J. Miyawaki, K. Fujii, T. Imazono, K. Horiba, Y. Ohtsubo, N. Inami, T. Nakatani, K. Inaba, A. Agui, H. Kimura, M. Takahasi, Design of Ultrahigh Energy Resolution RIXS Beamline at NanoTerasu, Journal of Physics: Conference Series. 2380 (2022).

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