Development of irradiation and analysis technology using electrostatic accelerator
In the tandem electrostatic accelerator, PIXE (Particle Induced X-ray Emission) elemental analysis and a single cell irradiation facility by Proton/Helium microbeam (SPICE; Single Particle Eradiation for Cell) are operated. We are developing new technologies and put into practical use based on requests from users. For example, the range of analyzed elements by PIXE has been covered from Oxygen, Fluorine to Uranium. At the SPICE, the speed and the area of cell irradiation also has been improved and the microbeam with the beam size of 2 µm can irradiate 10,000 cells per dish. The number of users from domestic and overseas universities and research institutes has increased in recent years. This facility will continue to actively engage in new technology development and research support that will contribute to the development of science.
SPICE, Microbeam Cell Irradiation Facility
Example of PIXE Analysis (NIST SRM2783)
メンバー
Oikawa Masakazu Director
- Ishikawa Takahiro Principal Researcher
- Miura Atsushi Principal Technical Staff
- Suda Mitsuru Senior Technical Staff
- Ohsawa Daisuke Senior Technical Staff
- Sugawara Kouki Senior Expert
Concurrent member
- Hamano Tsuyoshi Senior Expert
Selected Publications
- Unuma K.,Wen S.,Sugahara S.,Nagano S.,Aki T.,Ogawa T.,Takeda S.,Oikawa M.,Tojo A.: Thallium reabsorption via NKCC2 causes severe acute kidney injury with outer medulla-specific calcium crystal casts in rats.Archives of Toxicology,98,3973-3986,(2024)
- Kobayashi A., Hiroyama Y., Mamiya T., Oikawa M., Konishi T.:The COX-2/PGE2 Response Pathway Upregulates Radioresistance in A549 Human Lung Cancer Cells through Radiation-Induced Bystander Signaling.Biology, 12(11), (2023).
- Narongchai A.,Kobayashi A.,Cuihua L. Aphidet D.,Oikawa M.,Tengku Ahbrizal Tengku Ahmad,Konishi T.:Primary and Secondary Bystander Effects of Proton Microbeam Irradiation on Human Lung Cancer Cells under Hypoxic Conditions.Biology,12(12),1485,(2023)
- Jun W.,Oikawa M.,Konishi T.:Stimulation of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling by Nucleus Targeted Irradiation with Proton Microbeam.Biology,12(3),419, (2023)
- Mahmoud S., Matsui N.,Uo M.,Nikaido T.,Oikawa M.,Michael F. B.,Tagami J.:Morphological and elemental analysis of silver penetration into sound/demineralized dentin after SDF application.Dental Materials, 35(12),1718-1727,(2019)
- Ohsawa D.,Furusawa Y.,Kobayashi A.,Oikawa M.,Konishi T.:Analysis of SPICE microbeam size using fluorescent nuclear track detector (FNTD).Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms,453,9-14,(2019)
- Nakamura K.,Hamba H.,Nakashima S.,Sadr A.,Nikaido T.,Oikawa M.,Uo M.,Tagami J.: Effects of experimental pastes containing surface pre-reacted glass ionomer fillers on inhibition of enamel demineralization.DENTAL MATERIALS JOURNAL,36(4),(2017)
- Oikawa M.,Suya N.,Konishi T.,Ishikawa T.,Hamano T.,Takeda S.:Micro-PIXE analysis system at NIRS-electrostatic accelerator facility for various applications.International Journal of PIXE,25(3-4),217-225,(2016)
- Konishi T.,Oikawa M.,Suya N.,Ishikawa T.,Maeda T.,Kobayashi A.,Shiomi N.,Kodama K., Hamano T.,Takeda S.,Isono M.,Hieda K.,Uchihori Y.,Shirakawa Y.:SPICE-NIRS Microbeam:A Focused Vertical System for Proton Irradiation of a Single Cell for Radiobiological Research.Journal of Radiation Research,54,736-747,(2013)