Radiopharmaceuticals Production Group

Contribution for improvement in quality assurance of radiopharmaceuticals

We have provided diagnostic and therapeutic radiopharmaceuticals for clinical applications in and out of QST. We prepare radiopharmaceuticals according to the guideline of in-house PET radiopharmaceuticals standards authorized the Japanese Society of Nuclear Medicine (JSNM GMP) and provided high quality radiopharmaceuticals for using safe and reliable. Also, we have accepted requests from over 100 of PET center or hospitals for measuring the concentration of FDG or impurities included [¹⁸F]FDG injection.  For the promotion and development of clinical and research use of radiopharmaceuticals, we have developed and validated efficient synthesis methods and quality control testing methods. Also, we promote a standardization of synthesis and quality control testing methods of new or useful radiopharmaceuticals, and the transfer of these technology to other PET facilities.​

¹⁸F Labeled drug synthesis apparatus (left), ¹¹C labeled drug synthesis apparatus

Sterile Isolator

High Performance Liquid Chromatograph

Member

Kawamura Kazunori　Group leader

• Kadoma Ayumi Senior Technical Staff
• Hashimoto Hiroki Pharmacist

Selected Publications

1. Kawamura K., Yamasaki T., Fujinaga M., Kokufuta T., Zhang Y., Mori W., Kurihara Y., Ogawa M., Tsukagoe K., Nengaki N., Zhang MR.: Automated radiosynthesis and in vivo evaluation of ¹⁸F-labeled analog of the photosensitizer ADPM06 for planning photodynamic therapy. EJNMMI Radiopharm Chem 8(1), 14 (2023)
2. Kawamura K., Hashimoto H., Ohkubo T., Hanyu M., Ogawa M., Nengaki N., Arashi D., Kurihara Y., Fujishiro T., Togashi T., Sakai T., Muto M., Takei M., Ishii H., Saijo T., et al.: Automated radiosynthesis of [¹¹C]MTP38 - a phosphodiesterase 7 imaging tracer-using [¹¹C]hydrogen cyanide for clinical applications. J Labelled Comp Radiopharm 65(5), 140 (2022)
3. Kawamura K., Kumata K., Mori W., Fujinaga M., Kurihara Y., Ogawa M., Ohkubo T., Furutsuka K., Hashimoto H., Nengaki N., Zhang MR.: Radiosynthesis of 18F-fluoroethylated tracers via a simplified one-pot ¹⁸F-fluoroethylation method using [¹⁸F]fluoroethyl tosylate. Appl Radiat Isot 169, 109571 (2021).
4. Kawamura K., Hashimoto H., Furutsuka K., Ohkubo T., Fujishiro T., Togashi T., Arashi D., Sakai T., Muto M., Ogawa M., Kurihara Y., Nengaki N., Takei M., Nemoto K., Higuchi M., et al.: Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [¹⁸F]PM-PBB3 for clinical applications. J Labelled Comp Radiopharm 64(3), 109 (2021)
5. Hashimoto H., Furutsuka K., Kawamura K., Ohkubo T., Ogawa M., Kurihara Y., Nengaki N., Zhang MR.: Simultaneous measurements of the molar radioactivity, radiochemical purity and chemical impurity in the [¹¹C]choline injection using radio-HPLC with a corona-charged aerosol detector. Appl Radiat Isot 162, 109192 (2020)
6. Ohya T., Nagatsu K., Fukada M., Minegishi K., Zhang M.R.: Simple separation of ⁶⁷Cu from bulk zinc by coprecipitation using hydrogen sulfide gas and silver nitrate. Radiochim Acta 108(6), (2019)
7. Kawamura K., Shimoda Y., Yui J., Zhang Y., Yamasaki T., Wakizaka H., Hatori A., Xie L., Kumata K., Fujinaga M., Ogawa M., Kurihara Y., Nengaki N., Zhang MR.: A useful PET probe [¹¹C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus. Nucl Med Biol 45, 1 (2017)
8. Kawamura K., Kumata K., Takei M., Furutsuka K., Hashimoto H., Ito T., Shiomi S., Fujishiro T., Watanabe R., Igarashi N., Muto M., Yamasaki T., Yui J., Xie L., Hatori A., et al.: Efficient radiosynthesis and non-clinical safety tests of the TSPO radioprobe [¹⁸F]FEDAC: Prerequisites for clinical application. Nucl Med Biol 43(7), 445 (2016)
9. Hashimoto H., Kawamura K., Takei M., Igarashi N., Fujishiro T., Shiomi S., Watanabe R., Muto M., Furutsuka K., Ito T., Yamasaki T., Yui J., Nemoto K., Kimura Y., Higuchi M., et al.: Identification of a major radiometabolite of [¹¹C]PBB3. Nucl Med Biol 42(12), 905 (2015)
10. Hashimoto H., Kawamura K., Igarashi N., Takei M., Fujishiro T., Aihara Y., Shiomi S., Muto M., Ito T., Furutsuka K., Yamasaki T., Yui J., Xie L., Ono M., Hatori A., et al.: Radiosynthesis, photoisomerization, biodistribution, and metabolite analysis of ¹¹C-PBB3 as a clinically useful PET probe for imaging of tau pathology. J Nucl Med 55(9), 1532 (2014)