This page is current as of March 2023.
Based on the achievements of this project, the Quantum Applied Biotechnology Project was launched in April 2023.
Original papers
2022
Nagata, K., Ohashi, K., Hashimoto, C., El-Din, A., Sayed, H., Yasuda, T., Dutta, Kajihara, T., Mitani, H., Suzuki, M., Funayama, T., Oda, S. & Watanabe-Asaka, T., Responses of hematopoietic cells after ionizing-irradiation in anemic adult medaka (Oryzias latipes). International Journal of Radiation Biology, 2022. [10.1080/09553002.2022.2110328]
Mori, S., Tachibana, Y., Suzuki, M. & Harada, Y., Automatic worm detection to solve overlapping problems using a convolutional neural network. Scientific Reports, 12, 8521, 1-11, 2022. [10.1038/s41598-022-12576-9]
Nagata, K., Yasuda, T., Suzuki, M., Funayama, T., Mitani, H. & Oda, S., Testis-ova Induction by Microbeam Irradiation in P53-Deficient Medaka Testis. Cytologia, 87, 1-2, 2022. [10.1508/cytologia.87.1]
Ta, D.T., Umedachi, T., Suzuki, M. & Kawahara, Y., A Printable Soft-bodied Wriggle Robot with Frictional 2D-anisotropy Surface. Journal of Information Processing, 30, 201-208, 2022. [10.2197/ipsjjip.30.201]
Suzuki, M., Hattori, Y., Saito, T. & Harada, Y., Pond Assay for the Sensory Systems of Caenorhabditis elegans: A Novel Anesthesia-Free Method Enabling Detection of Responses to Extremely Low Chemical Concentrations. Biology, 11(2), 335, 2022. [10.3390/biology11020335]
2021
Yamasaki, A., Suzuki, M., Funayama, T., Moriwaki, T., Sakashita, T., Kobayashi, Y. & Zhang-Akiyama, Q.-M., High-Dose Irradiation Inhibits Motility and Induces Autophagy in Caenorhabditis elegans. International Journal of Molecular Sciences, 22(18), 9810, 2021. [10.3390/ijms22189810]
Yanagi, T., Kaminaga, K., Suzuki, M., Abe, H., Yamamoto, H., Ohshima, T., Kuwahata, A., Sekino, M., Imaoka, T., Kakinuma, S., Sugi, T., Kada, W., Hanaizumi, O. & Igarashi, R., All-Optical Wide-Field Selective Imaging of Fluorescent Nanodiamonds in Cells, In Vivo and Ex Vivo. ACS Nano, 15(8):12869-12879, 2021. [10.1021/acsnano.0c07740]
Sakamoto, K., Soh, Z., Suzuki, M., Iino, Y. & Tsuji, T., Forward and backward locomotion patterns in C. elegans generated by a connectome-based model simulation. Scientific Reports, 11: 13737, 2021. [10.1038/s41598-021-92690-2]
2020
Oizumi, T., Ohno, R., Yamabe, S., Funayama, T. & Nakamura, A. J., Repair kinetics of DNA double-strand breaks induced by simulated space radiation. Life, 10(12), 341, 2020. [10.3390/life10120341]
Yasuda, T., Funayama, T., Nagata, K., Li, D., Endo, T., Jia, Q., Suzuki, M., Ishikawa, Y., Mitani, H. & Oda, S., Collimated Microbeam Reveals that the Proportion of Non-Damaged Cells in Irradiated Blastoderm Determines the Success of Development in Medaka (Oryzias latipes) Embryos. Biology, 9(12), 447, 2020. [10.3390/biology9120447]
Suzuki, M., Soh, Z., Yamashita, H., Tsuji, T. & Funayama, T., Targeted Central Nervous System Irradiation of Caenorhabditis elegans Induces a Limited Effect on Motility. Biology, 9(9), 289, 2020. [10.3390/biology9090289]
Furukawa, S., Nagamatsu, A., Nenoi, M., Fujimori, A., Kakinuma, S., Katsube, T., Wang, B., Tsuruoka, C., Shirai, T., Nakamura, A. J., Sakaue-Sawano, A., Miyawaki, A., Harada, H., Kobayashi, M., Kobayashi, J., Kunieda, T., Funayama, T., Suzuki, M., Miyamoto, T., Hidema, J., Yoshida, Y. & Takahashi, A., Space Radiation Biology for “Living in Space”. BioMed Research International, 2020: 4703286, 2020. [10.1155/2020/4703286]
Funayama, T., Sakashita, T., Suzuki, M., Yokota, Y., Miyawaki, N., Kashiwagi, H., Satoh, T. & Kurashima, S., An irradiation device for biological targets using focused microbeams of cyclotron-accelerated heavy ions. Nuclear Instruments and Methods in Physics Research B, 465: 101-109, 2020. [10.1016/j.nimb.2019.12.028]
Yokota, Y., Wada, Y. & Funayama, T., Distinct modes of death in human neural stem and glioblastoma cells irradiated with carbon-ion and gamma-rays. International Journal of Radiation Biology, 96: 172-178, 2020. [10.1080/09553002.2020.1683639]
2019
Funayama, T., Heavy-ion microbeams for biological science: development of system and utilization for biological experiments in QST-Takasaki. Quantum Beam Science, 3: 13, 2019. [10.3390/qubs3020013]
Suzuki, M., Sakashita, T. & Funayama, T., Immobilization of live Caenorhabditis elegans individuals using an ultra-thin polydimethylsiloxane microfluidic chip with water retention. Journal of Visualized Experiments, e59008, 2019. [10.3791/59008]
Yokota, Y., Wada, Y. & Funayama, T., Distinct modes of death in human neural tem and glioblastoma cells irradiated with carbon-ion and gamma-rays. International Journal of Radiation Biology, in press, 2019. [10.1080/09553002.2020.1683639]
2018
Soh, Z., Sakamoto, K., Suzuki, M., Iino, Y. & Tsuji, T., A computational model of internal representations of chemical gradients in environments for chemotaxis of Caenorhabditis elegans. Scientific Reports 8, 17190, 2018. [10.1038/s41598-018-35157-1]
Suzuki, M., Sakashita, T., Hattori, Y., Yokota, Y., Kobayashi, Y. & Funayama, T., Development of ultra-thin chips for immobilization of Caenorhabditis elegans in microfluidic channels during irradiation and selection of buffer solution to prevent dehydration. Journal of Neuroscience Methods, 306: 32-37, 2018. [10.1016/j.jneumeth.2018.05.025]
2017
Autsavapromporn, N., Konishi, T., Liu, C., Plante, I., Funayama, T., Usami, N., Azzam, E. I. & Suzuki, M., A correlation of long term effects and radiation quality in the progeny of bystander cells after microbeam radiations: The experimental study of radiotherapy for cancer risk mitigation. Journal of Physics: Conference Series, 860: 012026, 2017. [10.1088/1742-6596/860/1/012026]
Saito, K., Funayama, T., Yokota, Y., Murakami, T. & Kobayashi, Y., Histone deacetylase inhibitors sensitize murine B16F10 melanoma cells to carbon ion irradiation by inducing G1 phase arrest. Biological and Pharmaceutical Bulletin, 40: 844-851, 2017. [10.1248/bpb.b16-01025]
Suzuki, M., Hattori, Y., Sakashita, T., Yokota, Y., Kobayashi, Y. & Funayama, T., Region-specific irradiation system with heavy-ion microbeam for active individuals of Caenorhabditis elegans. Journal of Radiation Research, 58: 881-886, 2017. [10.1093/jrr/rrx043]
Soh, Z., Suzuki, M. & Tsuji, T., An estimation method for environmental friction based on body dynamic model of Caenorhabditis elegans. Journal of Robotics, Networking and Artificial Life, 4: 32-40, 2017. [10.2991/jrnal.2017.4.1.8]
Yasuda, T., Kamahori, M., Nagata, K., Watanabe-Asaka, T., Suzuki, M., Funayama, T., Mitani, H. & Oda, S., Abscopal Activation of Microglia in Embryonic Fish Brain Following Targeted Irradiation with Heavy-Ion Microbeam. International Journal of Molecular Sciences, 18(7), 1428, 2017. [10.3390/ijms18071428]
2016
Nagata, K., Hashimoto, C., Watanabe-Asaka, T., Itoh, K., Yasuda, T., Ohta, K., Oonishi, H., Igarashi, K., Suzuki, M., Funayama, T., Kobayashi, Y., Nishimaki, T., Katsumura, T., Oota, H., Ogawa, M., Oga, A., Ikemoto, K., Itoh, H., Kutsuna, N., Oda, S. & Mitani, H., In vivo 3D analysis of systemic effects after local heavy-ion beam irradiation in an animal model. Scientific Reports, 6: 28691-, 2016. [10.1038/srep28691]
2015
Autsavapromporn, N., Plante, I., Liu, C., Konishi, T., Usami, N., Funayama, T., Azzam, E. I., Murakami, T. & Suzuki, M., Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: the relevance to cancer risk. International Journal of Radiation Biology, 91: 62-70, 2015. [10.3109/09553002.2014.950715]
Hattori, Y., Suzuki, M., Funayama, T., Kobayashi, Y., Yokoya, A. & Watanabe, R., A mathematical model of radiation-induced responses in a cellular population including cell-to-cell communications. Radiation Protection Dosimetry, 166: 142-147, 2015. [10.1093/rpd/ncv149]
Matsumoto, Y., Hamada, N., Aoki-Nakano, M., Funayama, T., Sakashita, T., Wada, S., Kakizaki, T., Kobayashi, Y. & Furusawa, Y., Dependence of the bystander effect for micronucleus formation on dose of heavy-ion radiation in normal human fibroblasts. Radiation Protection Dosimetry, 166: 152-156, 2015. [10.1093/rpd/ncv177]
Tomita, M., Matsumoto, H., Funayama, T., Yokota, Y., Otsuka, K., Maeda, M. & Kobayashi, Y., Nitric oxide-mediated bystander signal transduction induced by heavy-ion microbeam irradiation. Life Sciences in Space Research, 6: 36 - 43, 2015. [10.1016/j.lssr.2015.06.004]
Yokota, Y., Funayama, T., Mutou-Yoshihara, Y., Ikeda, H. & Kobayashi, Y., The bystander cell-killing effect mediated by nitric oxide in normal human fibroblasts varies with irradiation dose but not with radiation quality. International Journal of Radiation Biology, 91: 383-388, 2015. [10.3109/09553002.2015.1021960.]
2014
Murata, K., Noda, S., Oike, T., Takahashi, A., Yoshida, Y., Suzuki, Y., Ohno, T., Funayama, T., Kobayashi, Y., Takahashi, T. & Nakano, T., Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells. Journal of Radiation Research, 55: 658-664, 2014. [10.1093/jrr/rru002]
Takahashi, A., Kubo, M., Ma, H., Nakagawa, A., Yoshida, Y., Isono, M., Kanai, T., Ohno, T., Furusawa, Y., Funayama, T., Kobayashi, Y. & Nakano, T., Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation. Radiation Research, 182: 338-344, 2014. [10.1667/RR13782.1]
Sakashita, T., Hamada, N., Kawaguchi, I., Hara, T., Kobayashi, Y. & Saito, K., A branching process model for the analysis of abortive colony size distributions in carbon ion-irradiated normal human fibroblasts. Journal of Radiation Research, 55: 423-431, 2014. [10.1093/jrr/rrt129]
2013
Akeo, K., Hamada, N., Funayama, T., Akeo, Y. & Kobayashi, Y., Effects of ion beam irradiation on the expression of glutathione peroxidase in cultured human retinal vascular endothelial cells exposed to L-dopa. Tissue Culture Research Communications, 32: 195-202, 2013. [10.11418/jtca.32.195]
Autsavapromporn, N., Suzuki, M., Funayama, T., Usami, N., Plante, I., Yokota, Y., Mutou, Y., Ikeda, H., Kobayashi, K., Kobayashi, Y., Uchihori, Y., Hei, T. K., Azzamg, E. I. & Murakami, T., Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: The impact of radiation quality. Radiation Research, 180: 367-375, 2013. [10.1667/RR3111.1]
Sakashita, T., Hamada, N., Kawaguchi, I., Ouchi, N. B., Hara, T., Kobayashi, Y. & Saito, K., A framework for analysis of abortive colony size distributions using a model of branching processes in irradiated normal human fibroblasts. PloS one, 8: e70291, 2013. [10.1371/journal.pone.0070291]
2012
Horikawa, D. D., Yamaguchi, A., Sakashita, T., Tanaka, D., Hamada, N., Yukuhiro, F., Kuwahara, H., Kunieda, T., Watanabe, M., Nakahara, Y., Wada, S., Funayama, T., Katagiri, C., Higashi, S., Yokobori, S.-I., Kuwabara, M., Rothschild, L. J., Okuda, T., Hashimoto, H. & Kobayashi, Y., Tolerance of anhydrobiotic eggs of the tardigrade Ramazzottius varieornatus to extreme environments. Astrobiology, 12: 283-289, 2012. [10.1089/ast.2011.0669]
Musha, A., Yoshida, Y., Takahashi, T., Ando, K., Funayama, T., Kobayashi, Y., Negishi, A., Yokoo, S. & Nakano, T., Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells. Journal of Radiation Research, 53: 545-550, 2012. [10.1093/jrr/rrs012]
Mutou-Yoshihara, Y., Funayama, T., Yokota, Y. & Kobayashi, Y., Involvement of bystander effect in suppression of the cytokine production induced by heavy-ion broad beams. International Journal of Radiation Biology, 88: 258-266, 2012. [10.3109/09553002.2012.636138]
Sakashita, T., Suzuki, M., Hamada, N., Shimozawa, Y., Shirai-Fukamoto, K., Yokota, Y., Hamada-Sora, S., Kakizaki, T., Wada, S., Funayama, T. & Kobayashi, Y., Behavioral resistance of Caenorhabditis elegans against high-LET radiation exposure. Biological Sciences in Space, 26: 7-11, 2012. [10.2187/bss.26.7]
Sakashita, T., Suzuki, M., Hamada, N., Shimozawa, Y., Shirai-Fukamoto, K., Yokota, Y., Hamada-Sora, S., Kakizaki, T., Wada, S., Funayama, T. & Kobayashi, Y., Effects of low- and high-LET radiation on the salt chemotaxis learning in Caenorhabditis elegans. Biological Sciences in Space, 26: 21-25, 2012. [10.2187/bss.26.21]
Hattori, Y., Suzuki, M., Soh, Z., Kobayashi, Y. & Tsuji, T., Modeling of the pharyngeal muscle in Caenorhabditis elegans based on FitzHugh-Nagumo equations. Artificial Life and Robotics 17, 173-179, 2012. [10.1007/s10015-012-0064-y]
Hattori, Y., Suzuki, M., Soh, Z., Kobayashi, Y. & Tsuji, T., Theoretical and evolutionary parameter tuning of neural oscillators with a double-chain structure for generating rhythmic signals. Neural Computation 24, 635-675, 2012. [10.1162/NECO_a_00249]
Tanaka, A., Nakatani, Y., Hamada, N., Jinno-Oue, A., Shimizu, N., Wada, S., Funayama, T., Mori, T., Islam, S., Hoque, S. A., Shinagawa, M., Ohtsuki, T., Kobayashi, Y. & Hoshino, H., Ionising irradiation alters the dynamics of human long interspersed nuclear elements 1 (LINE1) retrotransposon.. Mutagenesis, 27: 599-607, 2012. [10.1093/mutage/ges025]
Yoshida, Y., Suzuki, Y., Al-Jahdari, W. S., Hamada, N., Funayama, T., Shirai, K., Katoh, H., Sakashita, T., Kobayashi, Y. & Nakano, T., Evaluation of the relative biological effectiveness of carbon ion beams in the cerebellum using the rat organotypic slice culture system. Journal of Radiation Research, 53: 87-92, 2012. [10.1269/jrr.11139A]
Kameya, H., Kikuchi, M., Hara, H., Furuta, M., Todoriki, S., Kobayashi, Y., Ukai, M. & Shimoyama, Y., Relaxation behaviors of free radicals from γ-irradiated black pepper using pulsed EPR spectroscopy. Applied magnetic resonance, 42: 153-159, 2012. [10.5772/51634]
Kikuchi, M., Kameya, H., Shimoyama, Y., Ukai, M. & Kobayashi, Y., Electron-spin relaxation phenomena in irradiated saccharides detected by pulsed electron paramagnetic resonance spectroscopy. Radiation Physics and Chemistry, 81: 1639-1645, 2012. [10.1016/j.radphyschem.2012.05.010]
Kimura, T., Takanami, T., Sakashita, T., Wada, S., Kobayashi, Y. & Higashitani, A., Innate immune genes including a mucin-like gene, mul-1, induced by ionizing radiation in Caenorhabditis elegans. Radiation research, 178: 313-320, 2012. [10.1667/RR2989.1]
2011
Watanabe, R., Wada, S., Funayama, T., Kobayashi, Y., Saito, K. & Furusawa, Y., Monte carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths. Radiation Protection Dosimetry, 143: 186-190, 2011. [10.1093/rpd/ncq539]
Kikuchi, M., Shimoyama, Y., Ukai, M. & Kobayashi, Y., ESR detection procedure of irradiated papaya containing high water content. Radiation Physics and Chemistry, 80: 664-667, 2011. [10.1016/j.radphyschem.2011.01.008]
Kiyohara, H., Ishizaki, Y., Suzuki, Y., Katoh, H., Hamada, N., Ohno, T., Takahashi, T., Kobayashi, Y. & Nakano, T., Radiation-induced ICAM-1 expression via TGF-β1 pathway on human umbilical vein endothelial cells; comparison between X-ray and carbon-ion beam irradiation. Journal of Radiation Research, 52: 287-292, 2011. [10.1269/jrr.10061]
2010
Hino, M., Hamada, N., Tajika, Y., Funayama, T., Morimura, Y., Sakashita, T., Yokota, Y., Fukamoto, K., Mutou, Y., Kobayashi, Y. & Yorifuji, H., Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells. Journal of Electron Microscopy, 59: 495-501, 2010. [10.1093/jmicro/dfq059]
Jinno-Oue, A., Shimizu, N., Hamada, N., Wada, S., Tanaka, A., Shinagawa, M., Ohtsuki, T., Mori, T., Saha, M. N., Hoque, A. S., Islam, S., Kogure, K., Funayama, T., Kobayashi, Y. & Hoshino, H., Irradiation with carbon ion beams induces apoptosis, autophagy, and cellular senescence in a human glioma-derived cell line. International Journal of Radiation Oncology, Biology, Physics, 76: 229-241, 2010. [10.1016/j.ijrobp.2009.08.054]
Kaminuma, T., Suzuki, Y., Shirai, K., Mizui, T., Noda, S.-E., Yoshida, Y., Funayama, T., Takahashi, T., Kobayashi, Y., Shirao, T. & Nakano, T., Effectiveness of carbon-ion beams for apoptosis induction in rat primary immature hippocampal neurons. Journal of Radiation Research, 51: 627-631, 2010. [10.1269/jrr.10050]
Yokota, Y., Funayama, T., Hase, Y., Hamada, N., Kobayashi, Y., Tanaka, A. & Narumi, I., Enhanced micronucleus formation in the descendants of gamma-ray-irradiated tobacco cells: Evidence for radiation-induced genomic instability in plant cells. Mutation Research, 691: 41-46, 2010. [10.1016/j.mrfmmm.2010.07.001]
Gusev, O., Nakahara, Y., Vanyagina, V., Malutina, L., Cornette, R., Sakashita, T., Hamada, N., Kikawada, T., Kobayashi, Y. & Okuda, T., Anhydrobiosis-associated nuclear DNA damage and repair in the sleeping chironomid: linkage with radioresistance. PLoS One, 5: e14008, 2010. [10.1371/journal.pone.0014008]
Kikuchi, M., Hussain, M. S., Morishita, N., Ukai, M., Kobayashi, Y. & Shimoyama, Y., ESR study of free radicals in mango. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 75: 310-313, 2010. [10.1016/j.saa.2009.10.029]
Hattori, Y., Suzuki, M., Soh, Z., Kobayashi, Y. & Tsuji, T., A novel tuning method for neural oscillators with a ladder-like structure based on oscillation analysis. Lecture Notes in Computer Science 6352, 401-410, 2010.
Suzuki, M., Sakashita, T., Tsuji, T. & Kobayashi, Y., Computational inferences on alteration of neurotransmission in chemotaxis learning in Caenorhabditis elegans. Lecture Notes in Computer Science 6352, 291-300, 2010. [10.1007/978-3-642-15819-3_38]
Tsuji, T., Suzuki, M., Takiguchi, N. & Ohtake, H., Biomimetic control based on a model of chemotaxis in Escherichia coli. Artificial Life 16, 155-177, 2010. [10.1162/artl.2010.16.2.16203]
2009
Al-Jahdari, W. S., Suzuki, Y., Yoshida, Y., Hamada, N., Shirai, K., Noda, S.-E., Funayama, T., Sakashita, T., Kobayashi, Y., Saito, S., Goto, F. & Nakano, T., The radiobiological effectiveness of carbon-ion beams on growing neurons. International Journal of Radiation Biology, 85: 700-709, 2009. [10.1080/09553000903020032]
Bigelow, A., Garty, G., Funayama, T., Randers-Pehrson, G., Brenner, D. & Geard, C., Expanding the question-answering potential of single-cell microbeams at RARAF, USA. Journal of Radiation Research, 50: A21-A28, 2009. [10.1269/jrr.08134S]
Fournier, C., Barberet, P., Pouthier, T., Ritter, S., Fischer, B., Voss, K.-O., Funayama, T., Hamada, N., Kobayashi, Y. & Taucher-Scholz, G., No evidence for DNA and early cytogenetic damage in bystander cells following heavy ion micro-irradiation at two facilities. Radiation Research, 171: 530-540, 2009. [10.1667/RR1457.1]
Furusawa, T., Fukamoto, K., Sakashita, T., Suzuki, E., Kakizaki, T., Hamada, N., Funayama, T., Suzuki, H., Ishioka, N., Wada, S., Kobayashi, Y. & Nagaoka, S., Targeted heavy-ion microbeam irradiation of the embryo but not yolk in the diapause-terminated egg of the silkworm, Bombyx mori, induces the somatic mutation. Journal of Radiation Research, 50: 371-375, 2009. [10.1269/jrr.09021]
Harada, K., Nonaka, T., Hamada, N., Sakurai, H., Hasegawa, M., Funayama, T., Kakizaki, T., Kobayashi, Y. & Nakano, T., Heavy-ion induced bystander killing of human lung cancer cells: the role of gap junctional intercellular communication. Cancer Science, 100: 684-688, 2009. [10.1111/j.1349-7006.2009.01093.x]
Hino, M., Hamada, N., Tajika, Y., Funayama, T., Morimura, Y., Sakashita, T., Yokota, Y., Fukamoto, K., Kobayashi, Y. & Yorifuji, H., Insufficient membrane fusion in dysferlin-deficient muscle fibers after heavy-ion irradiation. Cell Structure and Function, 34: 11-15, 2009. [10.1247/csf.08033]
Kawamura, H., Tatei, K., Nonaka, T., Obinata, H., Hattori, T., Ogawa, A., Kazama, H., Hamada, N., Funayama, T., Sakashita, T., Kobayashi, Y., Nakano, T. & Izumi, T., Ceramide induces myogenic differentiation and apoptosis in Drosophila Schneider cells. Journal of Radiation Research, 50: 161-169, 2009. [10.1269/jrr.08122]
Kobayashi, Y., Funayama, T., Hamada, N., Sakashita, T., Konishi, T., Imaseki, H., Yasuda, K., Hatashita, M., Takagi, K., Hatori, S., Suzuki, K., Yamauchi, M., Yamashita, S., Tomita, M., Maeda, M., Kobayashi, K., Usami, N. & Wu, L., Microbeam irradiation facilities for radiobiology in Japan and China. Journal of Radiation Research, 50: A29-A47, 2009. [10.1269/jrr.09009S]
Suzuki, M., Sakashita, T., Yanase, S., Kikuchi, M., Ohba, H., Higashitani, A., Hamada, N., Funayama, T., Fukamoto, K., Tsuji, T. & Kobayashi, Y., Effects of ionizing radiation on locomotory behavior and mechanosensation in Caenorhabditis elegans. Journal of Radiation Research, 50: 119-125, 2009. [10.1269/jrr.08087]
Yokota, Y., Wada, S., Hase, Y., Funayama, T., Kobayashi, Y., Narumi, I. & Tanaka, A., Kinetic analysis of double-strand break rejoining reveals the DNA reparability of γ-irradiated tobacco cultured cells. Journal of Radiation Research, 50: 171-175, 2009. [10.1269/jrr.08064]
Kume, T., Furuta, M., Todoriki, S., Uenoyama, N. & Kobayashi, Y., Status of food irradiation in the world. Radiation Physics and Chemistry, 78: 222-226, 2009. [10.1016/j.radphyschem.2008.09.009]
2008
Funayama, T., Wada, S., Yokota, Y., Fukamoto, K., Sakashita, T., Taguchi, M., Kakizaki, T., Hamada, N., Suzuki, M., Furusawa, Y., Watanabe, H., Kiguchi, K. & Kobayashi, Y., Heavy-ion microbeam system in JAEA for microbeam biology. Journal of Radiation Research, 49: 71-82, 2008. [10.1269/jrr.07085]
Hamada, N., Hara, T., Omura-Minamisawa, M., Ni, M., Funayama, T., Sakashita, T., Sora, S., Nakano, T. & Kobayashi, Y., Heavy-ion microbeam irradiation induces bystander killing of human cells. Biological Science in Space, 22: 46-53, 2008. [10.2187/bss.22.46]
Hamada, N., Ni, M., Funayama, T., Sakashita, T., Sora, S., Nakano, T. & Kobayashi, Y., A LET-dependent decrease in the apoptotic response of normal human fibroblast cultures to isosurvival doses of gamma-rays and energetic heavy ions. Biological Science in Space, 22: 41-45, 2008. [10.2187/bss.22.41]
Hamada, N., Hara, T., Omura-Minamisawa, M., Funayama, T., Sakashita, T., Sora, S., Nakano, T. & Kobayashi, Y., The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny. Cancer Letters, 268: 76-81, 2008. [10.1016/j.canlet.2008.03.029]
Hamada, N., Hara, T., Funayama, T., Sakashita, T. & Kobayashi, Y., Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts. Mutation Research, 637: 190-196, 2008. [10.1016/j.mrfmmm.2007.07.002]
Hamada, N., Ni, M., Funayama, T., Sakashita, T. & Kobayashi, Y., Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions. Mutation Research, 639: 35-44, 2008. [10.1016/j.mrfmmm.2007.11.001]
Hamada, N., Hara, T., Omura-Minamisawa, M., Funayama, T., Sakashita, T., Sora, S., Yokota, Y., Nakano, T. & Kobayashi, Y., Energetic heavy ions overcome tumor radioresistance caused by overexpression of Bcl-2. Radiotherapy and Oncology, 89: 231-236, 2008. [10.1016/j.radonc.2008.02.013]
Hamada, N., Kataoka, K., Sora, S., Hara, T., Omura-Minamisawa, M., Funayama, T., Sakashita, T., Nakano, T. & Kobayashi, Y., The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation. Radiotherapy and Oncology, 89: 227-230, 2008. [10.1016/j.radonc.2008.08.006]
Horikawa, D. D., Kunieda, T., Abe, W., Watanabe, M., Nakahara, Y., Yukuhiro, F., Sakashita, T., Hamada, N., Wada, S., Funayama, T., Katagiri, C., Kobayashi, Y., Higashi, S. & Okuda, T., Establishment of rearing system of the extremotolerant tardigrade Ramazzottius varieornatus : a new model animal for astrobiology. Astrobiology, 8: 557-568, 2008. [10.1089/ast.2007.0139]
Iwakawa, M., Hamada, N., Imadome, K., Funayama, T., Sakashita, T., Kobayashi, Y. & Imai, T., Expression profiles are differentiated in carbon ion-irradiated normal human fibroblasts and their bystander cells. Mutation Research, 642: 57-67, 2008. [10.1016/j.mrfmmm.2008.04.007]
Miyazawa, Y., Sakashita, T., Funayama, T., Hamada, N., Negishi, H., Kobayashi, A., Kaneyasu, T., Ooba, A., Morohashi, K., Kakizaki, T., Wada, S., Kobayashi, Y., Fujii, N. & Takahashi, H., Effects of locally targeted heavy-ion and laser microbeam on root hydrotropism in Arabidopsis thaliana. Journal of Radiation Research, 49: 373-379, 2008. [10.1269/jrr.07131]
Oishi, T., Sasaki, A., Hamada, N., Ishiuchi, S., Funayama, T., Sakashita, T., Kobayashi, Y., Nakano, T. & Nakazato., Y., Proliferation of cell death of human glioblastoma cells after carbon-ion beam exposure: morphologic and morphometric analyses. Neuropathology, 28: 408-416, 2008. [10.1111/j.1440-1789.2008.00899.x]
Sora, S., Hamada, N., Hara, T., Funayama, T., Sakashita, T., Yokota, Y., Nakano, T. & Kobayashi, Y., Exposure of normal human fibroblasts to heavy-ion radiation promotes their morphological differentiation. Biological Science in Space, 22: 54-58, 2008. [10.2187/bss.22.54]
Sakashita, T., Hamada, N., Ikeda, D. D., Suzuki, M., Yanase, S., Ishii, N. & Kobayashi, Y., Locomotion-learning behavior relationship in Caenorhabditis elegans following γ-ray irradiation. Journal of Radiation Research, 0802200021-0802200021, 2008. [10.1269/jrr.07102]
Sakashita, T., Hamada, N., Ikeda, D. D., Yanase, S., Suzuki, M., Ishii, N. & Kobayashi, Y., Modulatory effect of ionizing radiation on food-NaCl associative learning: the role of γ subunit of G protein in Caenorhabditis elegans. The FASEB Journal, 22: 713-720, 2008. [10.1096/fj.07-9259com]
Soh, Z., Suzuki, M., Tsuji, T., Takiguchi, N. & Ohtake, H. A neural network model of the olfactory system of mice: computer simulation of the attention behavior of mice for some components in an odor. Artificial Life and Robotics 12, 75-80, 2008.
2007
Akeo, K., Funayama, T., Akeo, N. H., Hiramitsu, T. & Kobayashi, Y., The effects of ultraviolet irradiation and hypoxia on expression of glutathione peroxidase and glyceraldehyde 3-phosphate dehydrogenase in the cultured retinal pigment epithelium. Tissue Culture Research Communications, 26: 155-163, 2007. [10.11418/jtca.26.149]
Fukamoto, K., Shirai, K., Sakata, T., Sakashita, T., Funayama, T., Hamada, N., Wada, S., Kakizaki, T., Shimura, S., Kobayashi, Y. & Kiguchi, K., Development of the irradiation method for the first instar silkworm larvae using locally targeted heavy-ion microbeam. Journal of Radiation Research, 48: 247-253, 2007. [10.1269/jrr.06066]
Hino, M., Wada, S., Tajika, Y., Morimura, Y., Hamada, N., Funayama, T., Sakashita, T., Kakizaki, T., Kobayashi, Y. & Yorifuji, H., Heavy ion microbeam irradiation induces ultrastructural changes in isolated single fibers of skeletal muscle. Cell Structure and Function, 32: 51-56, 2007. [10.1247/csf.06038]
Kakizaki, T., Hamada, N., Sakashita, T., Wada, S., Hara, T., Funayama, T., Hohdatsu, T., Natsuhori, M., Sano, T., Kobayashi, Y. & Ito, N., Vulnerability of feline T-lymphocytes to charged particles. Journal of Veterinary Medical Science, 69: 605-609, 2007. [10.1292/jvms.69.605]
Kanasugi, Y., Hamada, N., Wada, S., Funayama, T., Sakashita, T., Kakizaki, T., Kobayashi, Y. & Takakura, K., Role of DNA-PKcs in the bystander effect after low- or high-LET irradiation. International Journal of Radiation Biology, 83: 73-80, 2007. [10.1080/09553000601121116]
Kikuchi, M., Gunawardane, C. R., Alam, M. K., Dzomir, A. Z. M., Pitipanaarachchi, R. C., Funayama, T., Hamada, N., Sakashita, T., Wada, S., Satoh, K., Narumi, I. & Kobayashi, Y., Chemiluminescence ELISA for the detection of oxidative DNA base damage using anti-8-hydroxy-2-deoxyguanosine antibody: Application to the detection of irradiated food. RADIOISOTOPES, 56: 509-517, 2007. [10.3769/radioisotopes.56.509]
Sakashita, T., Hamada, N., Suzuki, M., Ikeda, D. D., Yanase, S., Ishii, N. & Kobayashi, Y., Effects of γ-Ray Irradiation on Olfactory Adaptation to Benzaldehyde in Caenorhabditis elegans. Biological Sciences in Space, 21: 117-120, 2007. [10.2187/bss.21.117]
Watanabe, M., Nakahara, Y., Sakashita, T., Kikawada, T., Fujita, A., Hamada, N., Horikawa, D. D., Wada, S., Kobayashi, Y. & Okuda, T., Physiological changes leading to anhydrobiosis improve radiation tolerance in Polypedilum vanderplanki larvae.. Journal of Insect Physiology, 53: 573-579, 2007. [10.1016/j.jinsphys.2007.02.008]
2006
Akeo, K., Funayama, T., Ogawa, A., Hamada, N., Akeo, Y. & Kobayashi, Y., Effects of gamma irradiation on bcl-2 and p53 expression in the porcine ciliary body. Experimental Animals, 55: 375-381, 2006. [10.1538/expanim.55.375]
Fukamoto, K., Shimura, S., Shirai, K., Kanekatsu, R., Kiguchi, K., Sakashita, T., Funayama, T. & Kobayashi, Y., Effects of heavy-ion irradiadion on the differentiation of epidermal cells in the silkworm, Bombyx mori. Journal of Insect Biotechnology and Sericology, 75: 107-114, 2006. [10.11416/jibs.75.107]
Hamada, N., Funayama, T., Wada, S., Sakashita, T., Kakizaki, T., Ni, M. & Kobayashi, Y., LET dependent survival of irradiated normal human fibroblasts and their descendents. Radiation Research, 166: 24-30, 2006. [10.1667/RR3579.1]
Horikawa, D. D., Sakashita, T., Katagiri, C., Watanabe, M., Kikawada, T., Nakahara, Y., Hamada, N., Wada, S., Funayama, T., Higashi, S., Kobayashi, Y., Okuda, T. & Kuwabara, M., Radiation tolerance in the tardigrade Milnesium tardigradum. International Journal of Radiation Biology, 82: 843-848, 2006. [10.1080/09553000600972956]
Kakizaki, T., Hamada, N., Wada, S., Funayama, T., Sakashita, T., Hohdatsu, T., Sano, T., Natsuhori, M., Kobayashi, Y. & Ito, N., Distinct modes of cell death by ionizing radiation observed in two lines of feline T-lymphocytes. Journal of Radiation Research, 47: 237-243, 2006. [10.1269/jrr.0618]
Kakizaki, T., Hamada, N., Funayama, T., Sakashita, T., Wada, S., Hohdatsu, T., Natsuhori, M., Sano, T., Kobayashi, Y. & Ito, N., Killing of feline T-lymphocytes by gamma-rays and energetic carbon ions. Journal of Veterinary Medical Science, 68: 1269-73, 2006. [10.1292/jvms.68.1269]
Ling, E., Shirai, K., Kanekatsu, R., Kiguchi, K., Kobayashi, Y., Funayama, T. & Watanabe, H., Contribution of circulating hemocytes to the regeneration of heavy ion beams (12C5+) irradiated hematopoietic organs in the silkworm, Bombyx mori, through the way of phagocytosis of injured cells after invasion. Developmental and Comparative Immunology, 30: 531-543, 2006. [10.1016/j.dci.2005.08.003]
Satoh, K., Wada, S., Kikuchi, M., Funayama, T., Narumi, I. & Kobayashi, Y., Method for detecting DNA strand breaks in mammalian cells using the Deinococcus radiodurans PprA protein. Mutation Research, 596: 36-42, 2006. [10.1016/j.mrfmmm.2005.11.006]
Shao, C., Furusawa, Y., Kobayashi, Y. & Funayama, T., Involvement of gap junctional intercellular communication in the bystander effect induced by broad-beam or microbeam heavy ions. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 251: 629-638, 2006. [10.1016/j.nimb.2006.06.009]
Sugimoto, T., Dazai, K., Sakashita, T., Funayama, T., Wada, S., Hamada, N., Kakizaki, T., Kobayashi, Y. & Higashitani, A., Cell cycle arrest and apoptosis in Caenorhabditis elegans germline cells following heavy-ion microbeam irradiation. International Journal of Radiation Biology, 82: 31-38, 2006. [10.1080/09553000600577821]
Watanabe, M., Sakashita, T., Fujita, A., Kikawada, T., Horikawa, D. D., Nakahara, Y., Wada, S., Funayama, T., Hamada, N., Kobayashi, Y. & Okuda, T., Biological effects of anhydrobiosis in an African chironomid, Polypedilum vanderplanki on radiation tolerance. International Journal of Radiation Biology, 82: 587-592, 2006. [10.1080/09553000600876652]
Watanabe, M., Sakashita, T., Fujita, A., Kikawada, T., Nakahara, Y., Hamada, N., Horikawa, D. D., Wada, S., Funayama, T., Kobayashi, Y. & Okuda, T., Estimation of radiation tolerance to high LET heavy ions in an anhydrobiotic insect, Polypedilum vanderplanki. International Journal of Radiation Biology, 82: 835-842, 2006. [10.1080/09553000600979100]
Shirai, K., Mizui, T., Suzuki, Y., Kobayashi, Y., Nakano, T. & Shirao, T., Differential effects of x-irradiation on immature and mature hippocampal neurons in vitro.. Neuroscience Letters, 399: 57-60, 2006. [10.1016/j.neulet.2006.01.048]
Fukamoto, K., Shirai, K., Sato, S., Kanekatsu, R., Kiguchi, K. & Kobayashi, Y., Process of in vivo cyst formation from the implanted larval integument in the sweet potato hornworm, Agrius convolvuli: A simple model for studying wound healing. Journal of Insect Biotechnology and Sericology, 75: 99-106, 2006. [10.11416/jibs.75.99]
2005
Funayama, T., Wada, S., Kobayashi, Y. & Watanabe, H., Irradiation of mammalian cultured cells with collimated heavy ion microbeam. Radiation Research, 163: 241-246, 2005. [10.1667/RR3301]
Tanaka, M., Narumi, I., Funayama, T., Kikuchi, M., Watanabe, H., Matsunaga, T., Nikaido, O. & Yamamoto, K., Characterization of pathways dependent on the uvde, uvrA1, or uvrA2 gene product for ultraviolet resistance in Deinococcus radiodurans. Journal of Bacteriology, 187: 3693-3697, 2005. [10.1128/JB.187.11.3693-3697.2005]
Wada, S., Khoa, T. V., Kobayashi, Y., Funayama, T., Ogihara, K., Ueno, S. & Ito, N., Prediction of cellular radiosensitivity from DNA damage induced by γ-rays and carbon ion irradiation in canine tumor cells. Journal of Veterinary Medical Science, 67: 1091-1097, 2005. [10.1292/jvms.67.1089]
Yokota, Y., Shikazono, N., Tanaka, A., Hase, Y., Funayama, T., Wada, S. & Inoue, M., Comparative radiation tolerance based on the induction of DNA double-strand breaks in tobacco BY-2 cells and CHO-K1 cells irradiated with γrays. Radiation Research, 163: 520-525, 2005. [10.1667/RR3355]
Mehnati, P., Morimoto, S., Yatagai, F., Furusawa, Y., Kobayashi, Y., Wada, S., Kanai, T., Hanaoka, F. & Sasaki, H., Exploration of ‘over kill effect’of high-LET Ar-and Fe-ions by evaluating the fraction of non-hit cell and interphase death. Journal of Radiation Research, 46: 343-350, 2005. [10.1269/jrr.46.343]
2004
Hayashi, H., Wada, S., Funayama, T., Narumi, I., Kobayashi, Y., Watanabe, H., Furuta, M. & Uehara, K., Evaluation of the resistance of Euglena gracilis to the ion beam radiation. Journal of Eukaryotic Microbiology, 51: 321-324, 2004. [10.1111/j.1550-7408.2004.tb00573.x]
Narumi, I., Satoh, K., Cui, S., Funayama, T., Kitayama, S. & Watanabe, H., PprA: a novel protein from Deinococcus radiodurans that stimulates DNA ligation. Molecular Microbiology, 54: 278-285, 2004. [10.1111/j.1365-2958.2004.04272.x]
Hayashi, H., Narumi, I., Wada, S., Kikuchi, M., Furuta, M., Uehara, K. & Watanabe, H., Light dependency of resistance to ionizing radiation in Euglena gracilis.. Journal of Plant Physiology, 161: 1101-1106, 2004. [10.1016/j.jplph.2004.04.005]
2003
Kiguchi, K., Shirai, K., Kanekatsu, R., Kobayashi, Y., Tu, Z., Funayama, T. & Watanabe, H., Radiosurgery using heavy ion microbeams for biological study: Fate mapping of the cellular blastoderm-stage egg of the silkworm, Bombyx mori. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 210: 312-315, 2003. [10.1016/S0168-583X(03)01054-1]
Kitayama, S., Narumi, I., Funayama, T. & Watanabe, H., Cloning of structural gene of Deinococcus radiodurans UV-endonuclease beta. Bioscience, Biotechnology, and Biochemistry, 67: 613-616, 2003. [10.1271/bbb.67.613]
Kobayashi, Y., Funayama, T., Wada, S., Taguchi, M. & Watanabe, H., Irradiation of single mammalian cells with a precise number of energetic heavy ions - Applications of microbeams for studying cellular radiation response. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 210: 308-311, 2003. [10.1016/S0168-583X(03)01047-4]
Ling, E., Fukamoto, K., Xu, S., Shirai, K., Kanekatsu, R., Kobayashi, Y., Tu, Z., Funayama, T., Watanabe, H. & Kiguchi, K., Regeneration of hemopoietic organs in the silkworm, Bombyx mori, after locally targeted irradiation with heavy ion beams. Journal of Insect Biotechnology and Sericology, 72: 95-100, 2003. [10.11416/jibs.72.95]
Ling, E., Shirai, K., Kanekatsu, R., Kobayashi, Y., Tu, Z., Funayama, T., Watanabe, H. & Kiguchi, K., Why does hemocyte density rise during the wandering stage of the silkworm, Bombyx mori?. Journal of Insect Biotechnology and Sericology, 72: 101-109, 2003. [10.11416/jibs.72.101]
Shao, C., Furusawa, Y., Kobayashi, Y., Funayama, T. & Wada, S., Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. FASEB Journal, Aug;17: 1422-1427, 2003. [0.1096/fj.02-1115com]
Wada, S., Khoa, T. V., Kobayashi, Y., Funayama, T., Yamamoto, K., Natsuhori, M. & Ito, N., Detection of radiation-induced apoptosis using the comet assay. Journal of Veterinary Medical Science, 65: 1161-1166, 2003. [10.1292/jvms.65.1161]
Wada, S., Kurahayashi, H., Kobayashi, Y., Funayama, T., Yamamoto, K., Natsuhori, M. & Ito, N., The relationship between cellular radiosensitivity and radiation-induced DNA damage measured by the comet assay. Journal of Veterinary Medical Science, 65: 471-477, 2003. [10.1292/jvms.65.471]
Wada, S., Natsuhori, M., Ito, N., Funayama, T. & Kobayashi, Y., Detection of DNA damage induced by heavy ion irradiation in the individual cells with comet assay. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 206: 553-556, 2003. [10.1016/S0168-583X(03)00820-6]
Yokota, Y., Funayama, T., Kobayashi, Y., Sakashita, T., Wada, S., Hase, Y., Shikazono, N., Tanaka, A. & Inoue, M., Development of an ion microbeam system for irradiating single plant cell[s]. Biological Science in Space, 17: 298-301, 2003. [10.2187/bss.17.298]
Tu, Z.-L., Kobayashi, Y., Kiguchi, K. & Watanabe, H., Irradiation effect of different heavy ions and track section on the silkworm Bombyx mori. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 206: 591 - 595, 2003. [10.1016/S0168-583X(03)00842-5]
Review
Suzuki, M. & Funayama, T.，Functional analysis of individuals using heavy ion microbeams．Radiation Biology Research Communications, 57： 114-131, 2022. (in Japanese)
Hamada, N., Imaoka, T., Masunaga, S.-i., Ogata, T., Okayasu, R., Takahashi, A., Kato, T. A., Kobayashi, Y., Ohnishi, T., Ono, K., Shimada, Y. & Teshima, T., Recent advances in the biology of heavy-ion cancer therapy. Journal of Radiation Research, 51: 365-383, 2010.
Sakashita, T., Takanami, T., Yanase, S., Hamada, N., Suzuki, M., Kimura, T., Kobayashi, Y., Ishii, N. & Higashitani, A., Radiation biology of Caenorhabditis elegans: germ cell response, aging and behavior. Journal of Radiation Research, 1003040138-1003040138, 2010.
Funayama, T., Hamada, N., Sakashita, T. & Kobayashi, Y., Heavy-ion microbeams - Development and applications in biological studies. (Invited Review Article) IEEE Transactions on Plasma Science, 36: 1432-1440, 2008. [10.1109/TPS.2008.927270]
Hamada, N., Matsumoto, H., Hara, T. & Kobayashi, Y., Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects. Journal of Radiation Research, 0702230007-0702230007, 2007.
Matsumoto, H., Hamada, N., Takahashi, A., Kobayashi, Y. & Ohnishi, T., Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses. Journal of Radiation Research, 48: 97-106, 2007.
Kobayashi, Y., Funayama, T., Wada, S., Furusawa, Y., Aoki, M., Shao, C., Yokota, Y., Sakashita, T., Matsumoto, Y., Kakizaki, T. & Hamada, N., Microbeams of heavy charged particles. Biological Science in Space, 18: 235-240, 2004. [10.2187/bss.18.235]