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QST 前臨床MRIに関する情報ページ

掲載日：2021年10月5日更新
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研究用MRI共有プラットフォーム

文部科学省・先端研究基盤共用促進事業

量研では、研究に使用する前臨床MRI装置（実験用MRI装置）を運用し、研究開発を行っています。主に量子生命･医学部門というセクションにおいて、医科学研究を実施する量子医科学研究所、基礎科学を研究する量子生命科学研究所、そして放射線の生物影響などを調べる放射線医学研究所の３つの研究所を中心に、量研の他部門および大学・研究所・企業と連携して、活発な研究開発を行っています。

2021年7月より標記事業に採択され、「研究用MRI共有プラットフォーム」に参画しています。

関連するプレスリリース

「酸化ストレス」を検出する世界初の量子センサーを開発 -光とMRIを使い、生活習慣病や炎症から体を守る先制医療に向けて-
MRI量子センサーの画像
がんの血管構造を三次元で高精細に可視化～血管を「見ながら」効果のある治療を選ぶ未来の実現へ～
「みる」と「なおす」2つの機能をもつナノ薬剤送達治療システムを開発～重粒子線との併用で副作用が少ないがん治療の実現へ～
がんの悪性度を検知する「ナノマシン造影剤」を開発

主な研究分野と成果

  • ナノ粒子による新規造影剤開発とがんの診断・治療に関する研究開発
  • 脳機能や脳領域間の連繋、脳血管に関する研究
  • 放射線治療や放射線被ばくに対する研究
  • 生体組織の酸化還元状態（REDOX）の検出や制御に関する研究
  • MRIに関連する技術開発（高速撮像法・新規パルスシーケンス・新規解析法・マイクロイメージング・超偏極など）

前臨床MRIの装置紹介

生物医学研究や創薬に使われる研究専用のMRI装置は、前臨床MRI装置と呼ばれます。現在、量医研では3台の前臨床MRI装置が稼働しています。共用につきましては、代表機関の大阪大学「研究用MRI共有プラットフォーム」ポータルサイトまでお問い合わせください。

  • コンパクト1.0テスラMRI装置 [Available]
  • 20cm口径7.0テスラMRI装置
  • 40cm口径7.0テスラMRI装置
MRI装置と実験室

前臨床MRIを使った研究成果一覧

  1. Sawada K, Kamiya S, Aoki I. The Proliferation of Dentate Gyrus Progenitors in the Ferret Hippocampus by Neonatal Exposure to Valproic Acid. Front Neurosci. 2021 Sep 28;15:736313. doi: 10.3389/fnins.2021.736313.
  2. Takado Y, Takuwa H, Sampei K, Urushihata T, Takahashi M, Shimojo M, Uchida S, Nitta N, Shibata S, Nagashima K, Ochi Y, Ono M, Maeda J, Tomita Y, Sahara N, Near J, Aoki I, Shibata K, Higuchi M. MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice. J Cereb Blood Flow Metab. 2021 Sep 13:271678X211045449. doi: 10.1177/0271678X211045449. Epub ahead of print. PMID: 34515548.
  3. Liu J, Cabral H, Song B, Aoki I, Chen Z, Nishiyama N, Huang Y, Kataoka K, Mi P. Nanoprobe-Based Magnetic Resonance Imaging of Hypoxia Predicts Responses to Radiotherapy, Immunotherapy, and Sensitizing Treatments in Pancreatic Tumors. ACS Nano. 2021 Aug 6. doi: 10.1021/acsnano.1c04263. Epub ahead of print. PMID: 34355882.
  4. Yuba E, Takashima M, Hayashi T, Kokuryo D, Aoki I, Harada A, Aoshima S, Krishnan UM, Kono K. Multifunctional Traceable Liposomes with Temperature-Triggered Drug Release and Neovasculature-Targeting Properties for Improved Cancer Chemotherapy. Mol Pharm. 2021 Sep 6;18(9):3342-3351. doi: 10.1021/acs.molpharmaceut.1c00263. Epub 2021 Jul 29. PMID: 34324363.
  5. Okada S, Takayasu S, Sumiyoshi A, Aoki I, Nakamura H. MRI-Based Glucose Assay Using Magnetic Nanoparticle Sensors. Anal Sci. 2021 Jul 9. doi: 10.2116/analsci.21P082. Epub ahead of print. PMID: 34248090.
  6. Matsumoto KI, Nakanishi I, Zhelev Z, Bakalova R, Aoki I. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging. Antioxid Redox Signal. 2021 Jul 28. doi: 10.1089/ars.2021.0110. Epub ahead of print. PMID: 34148403.
  7. Sawada K, Kamiya S, Aoki I. Neonatal valproic acid exposure produces altered gyrification related to increased parvalbumin-immunopositive neuron density with thickened sulcal floors. PLoS One. 2021 Apr 20;16(4):e0250262. doi:10.1371/journal.pone.0250262. PMID: 33878144; PMCID: PMC8057614.
  8. Okubo K, Takeda R, Murayama S, Umezawa M, Kamimura M, Osada K, Aoki I, Soga K. Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging. Sci Technol Adv Mater. 2021 Mar 10;22(1):160-172. doi: 10.1080/14686996.2021.1887712. (IF = 8.090)
  9. Fairley LH, Sahara N, Aoki I, Ji B, Suhara T, Higuchi M, Barron AM. Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy. J Neuroinflammation. 2021 Mar 19;18(1):76. doi:10.1186/s12974-021-02122-1. PMID: 33740987; PMCID: PMC7980620. (IF = 5.193)
  10. Kimura A, Jo JI, Yoshida F, Hong Z, Tabata Y, Sumiyoshi A, Taguchi M, Aoki I. Ultra-small size gelatin nanogel as a blood brain barrier impermeable contrast agent for magnetic resonance imaging. Acta Biomater. 2021 Feb 15:S1742-7061(21)00102-1. doi: 10.1016/j.actbio.2021.02.016. Epub ahead of print. PMID: 33601066.
  11. Ji B, Ono M, Yamasaki T, Fujinaga M, Zhang MR, Seki C, Aoki I, Kito S, Sawada M, Suhara T, Sahara N, Higuchi M. Detection of Alzheimer's disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein. J Cereb Blood Flow Metab. 2021 Feb 8:271678X21992457. doi: 10.1177/0271678X21992457. Epub ahead of print. PMID: 33557690.
  12. Lazarova D, Semkova S, Zlateva G, Higashi T, Aoki I, Bakalova R. Quantum Sensors to Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging. Anal Chem. 2021 Feb 9;93(5):2828-2837. doi: 10.1021/acs.analchem.0c04116. Epub 2021 Jan 28. PMID: 33508934.
  13. Setiawan H, Yuba E, Harada A, Aoki I, Kono K. Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics. Nano Select. 2020 Dec 23;1-12. doi:10.1002/nano.202000218.
  14. Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615. (IF = 5.076)
  15. Tateishi K, Miyake Y, Kawazu M, Sasaki N, Nakamura T, Sasame J, Yoshii Y, Ueno T, Miyake A, Watanabe J, Matsushita Y, Shiba N, Udaka N, Ohki K, Fink AL, Tummala SS, Natsumeda M, Ikegaya N, Nishi M, Ohtake M, Miyazaki R, Suenaga J, Murata H, Aoki I, Miller JJ, Fujii Y, Ryo A, Yamanaka S, Mano H, Cahill DP, Wakimoto H, Chi AS, Batchelor TT, Nagane M, Ichimura K, Yamamoto T. A hyperactive RelA/p65-hexokinase 2 signaling axis drives primary central nervous system lymphoma. Cancer Res. 2020 Oct 16:canres.2425.2020. doi:10.1158/0008-5472.CAN-20-2425. Epub ahead of print. PMID: 33067267.
  16. Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E, Yano K, Kato Y, Kumamoto T, Aoki I, Ogihara T. Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging. Int J Pharm. 2020 Aug 30;586:119575. doi: 10.1016/j.ijpharm.2020.119575. Epub 2020 Jul 2. PMID: 32622809. (IF = 4.213)
  17. Barron AM, Ji B, Fujinaga M, Zhang MR, Suhara T, Sahara N, Aoki I, Tsukada H, Higuchi M. In vivo positron emission tomography imaging of mitochondrial abnormalities in a mouse model of tauopathy. Neurobiol Aging. 2020 Oct;94:140-148. doi: 10.1016/j.neurobiolaging.2020.05.003. Epub 2020 May 19. PMID: 32623260.
  18. Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M. Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model. J Neurosci. 2020 Apr 22;40(17):3491-3501. doi:10.1523/JNEUROSCI.2880-19.2020. Epub 2020 Apr 7. PMID: 32265258; PMCID: PMC7178904.
  19. Bakalova R, Zhelev Z, Miller T, Aoki I, Higashi T. Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration? Oxid Med Cell Longev. 2020 Jan 11;2020:1504048. doi: 10.1155/2020/1504048. PMID: 32411317; PMCID: PMC7201545. Review.  (IF = 5.076)
  20. Sawada K, Kamiya S, Aoki I. Asymmetry of Cerebellar Lobular Development in Ferrets. Symmetry. 2020 May;12(5):735. doi:10.3390/sym12050735.
  21. Qin C, Hou X, Khan T, Nitta N, Yanagawa M, Sakurai Y, Suzuki M, Masunaga SI, Tanaka H, Sakurai Y, Takahashi H, Aoki I, Yanagie H, Cabral H. Enhanced MRI-Guided Gadolinium(III) Neutron Capture Therapy by Polymeric Nanocarriers Promoting Tumor Accumulation and Intracellular Delivery. Chem Nano Mat. 2020 Mar;6:412-419. doi:10.1002/cnma.201900730. (IF = 3.384)
  22. Tanimoto Y, Yamasaki T, Nagoshi N, Nishiyama Y, Nori S, Nishimura S, Iida T, Ozaki M, Tsuji O, Ji B, Aoki I, Jinzaki M, Matsumoto M, Fujibayashi Y, Zhang MR, Nakamura M, Okano H. In vivo monitoring of remnant undifferentiated neural cells following human iPS cell-derived neural stem/progenitor cells transplantation. Stem Cells Transl Med. 2020 Apr;9(4):465-477. doi:10.1002/sctm.19-0150. Epub 2020 Jan 6. PMID: 31904914; PMCID: PMC7103627.
  23. Bakalova R, Zhelev Z, Miller T, Aoki I, Higashi T. New potential biomarker for stratification of patients for pharmacological vitamin C in adjuvant settings of cancer therapy. Redox Biol. 2020 Jan;28:101357. doi: 10.1016/j.redox.2019.101357. Epub 2019 Oct 23. Review. PubMed PMID: 31678721.
  24. Grandjean J, Canella C, Anckaerts C, Ayrancı G, Bougacha S, Bienert T, Buehlmann D, Coletta L, Gallino D, Gass N, Garin CM, Nadkarni NA, Hübner NS, Karatas M, Komaki Y, Kreitz S, Mandino F, Mechling AE, Sato C, Sauer K, Shah D, Strobelt S, Takata N, Wank I, Wu T, Yahata N, Yeow LY, Yee Y, Aoki I, Chakravarty MM, Chang WT, Dhenain M, von Elverfeldt D, Harsan LA, Hess A, Jiang T, Keliris GA, Lerch JP, Meyer-Lindenberg A, Okano H, Rudin M, Sartorius A, Van der Linden A, Verhoye M, Weber-Fahr W, Wenderoth N, Zerbi V, Gozzi A. Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis. Neuroimage. 2019 Oct 12;205:116278. doi: 10.1016/j.neuroimage.2019.116278. [Epub ahead of print] PubMed PMID: 31614221.
  25. Eguchi Y, Murayama S, Kanamoto H, Abe K, Miyagi M, Takahashi K, Ohtori S, Aoki I. Minimally invasive manganese-enhanced magnetic resonance imaging for the sciatic nerve tract tracing used intra-articularly administrated dextran–manganese encapsulated nanogels. JOR spine. 2019 June 6;2:e1059:1-8. doi:10.1002/jsp2.1059.
  26. Nakamura M, Yamasaki T, Ueno M, Shibata S, Ozawa Y, Kamada T, Nakanishi I, Yamada KI, Aoki I, Matsumoto KI. Radiation-induced redox alteration in the mouse brain. Free Radic Biol Med. 2019 Aug 22;143:412-421. doi:10.1016/j.freeradbiomed.2019.08.020. PubMed PMID: 31446055.
  27. Lazarova D, Shibata S, Ishii I, Zlateva G, Zhelev Z, Aoki I, Higashi T, Bakalova R. Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress. Gen Physiol Biophys. 2019 May;38(3):191-204. doi: 10.4149/gpb_2019001. PubMed PMID: 31184306.
  28. Zhelev Z, Georgieva E, Lazarova D, Semkova S, Aoki I, Gulubova M, Higashi T, Bakalova R. "Redox Imaging" to Distinguish Cells with Different Proliferative Indexes: Superoxide, Hydroperoxides, and Their Ratio as Potential Biomarkers. Oxid Med Cell Longev. 2019 Apr 8;2019:6373685. doi: 10.1155/2019/6373685. eCollection 2019. PubMed PMID: 31089411; PubMed Central PMCID: PMC6476105. (IF=4.9)
  29. Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H. Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience. 2019 May 31;15:95-108. doi: 10.1016/j.isci.2019.04.007. Epub 2019 Apr 9. PubMed PMID: 31055217; PubMed Central PMCID: PMC6501120. (IF = 8.032)
  30. Mimura K, Oga T, Sasaki T, Nakagaki K, Sato C, Sumida K, Hoshino K, Saito K, Miyawaki I, Suhara T, Aoki I, Minamimoto T, Ichinohe N. Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model. Neuroimage. 2019 Jul 15;195:243-251. doi:10.1016/j.neuroimage.2019.04.006. Epub 2019 Apr 3. PubMed PMID: 30953832. (IF = 5.426)
  31. Nonaka H, Nakanishi Y, Kuno S, Ota T, Mochidome K, Saito Y, Sugihara F, Takakusagi Y, Aoki I, Nagatoishi S, Tsumoto K, Sando S. Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction. Nat Commun. 2019 Feb 20;10(1):876. doi: 10.1038/s41467-019-08833-7. PubMed PMID:30787298; PubMed Central PMCID: PMC6382819. (IF: 12.353)
  32. Shibata S, Shinozaki N, Suganami A, Ikegami S, Kinoshita Y, Hasegawa R, Kentaro H, Okamoto Y, Aoki I, Tamura Y, Iwadate Y. Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model. Oncotarget. 2019 Jan 4;10(2):175-183. doi: 10.18632/oncotarget.26544. eCollection 2019 Jan 4. PubMed PMID: 30719212; PubMed Central PMCID: PMC6349435. (IF: 5.168)
  33. Saito S, Sawada K, Aoki I. Prenatal Irradiation-Induced Hippocampal Abnormalities in Rats Evaluated Using Manganese-Enhanced MRI. Front Neural Circuits. 2018 Dec 17;12:112. doi: 10.3389/fncir.2018.00112. eCollection 2018. PubMed PMID: 30618648; PubMed Central PMCID: PMC6304475.
  34. Sato C, Sawada K, Wright D, Higashi T, Aoki I. Isotropic 25-Micron 3D Neuroimaging Using ex vivo Microstructural Manganese-Enhanced MRI (MEMRI). Front Neural Circuits. 2018 Dec 6;12:110. doi: 10.3389/fncir.2018.00110. eCollection 2018. PubMed PMID: 30574072; PubMed Central PMCID: PMC6291442. (IF:3.131, HL:4.2)
  35. Obata T, Kershaw J, Tachibana Y, Miyauchi T, Abe Y, Shibata S, Kawaguchi H, Ikoma Y, Takuwa H, Aoki I, Yasui M. Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells. Sci Rep. 2018 Dec 18;8(1):17954. doi: 10.1038/s41598-018-36264-9. PubMed PMID: 30560905; PubMed Central PMCID: PMC6298983.
  36. Morishita K, Ueki S, Fuchi Y, Murayama S, Kaneko T, Narita N, Kobayashi S, Hirai G, Aoki I, Karasawa S. Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging. ACS Appl Nano Mater. 2018 Nov 26;1:6967-6975. doi: 10.1021/acsanm.8b01774. (IF: N/A)
  37. Urushihata T, Takuwa H, Seki C, Tachibana Y, Takahashi M, Kershaw J, Takado Y, Aoki I, Higuchi M, Ito H, Obata T. Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow. Magn Reson Med Sci. 2018 Oct 10;17(4):318-324. doi: 10.2463/mrms.mp.2017-0149. Epub 2018 Feb 13. PubMed PMID: 29434092. (IF: 1.141, HL: 6.0, 2016)
  38. Araki T, Fuchi Y, Murayama S, Shiraishi R, Oyama T, Aso M, Aoki I, Kobayashi S, Yamada KI, Karasawa S. Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative. Nanomaterials (Basel). 2018 Oct 2;8(10). pii: E782. doi: 10.3390/nano8100782. PubMed PMID: 30279322. (IF: 3.504, 2017).
  39. Nakakaji R, Umemura M, Mitsudo K, Kim JH, Hoshino Y, Sato I, Masuda T, Yamamoto M, Kioi M, Koizumi T, Fujita T, Yokoyama U, Iida M, Sato M, Sato H, Murofushi S, Shibata S, Aoki I, Eguchi H, Tohnai I, Ishikawa Y. Treatment of oral cancer using magnetized paclitaxel. Oncotarget. 2018 Feb 26;9(21):15591-15605. doi: 10.18632/oncotarget.24570. eCollection 2018 Mar 20. PubMed PMID: 29643995; PubMed Central PMCID: PMC5884650. (IF: 5.168)
  40. Nitta N, Takakusagi Y, Kokuryo D, Shibata S, Tomita A, Higashi T, Aoki I, Harada M. Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging. Nanomedicine. 2018 Apr 4;14(4):1315-1324. doi: 10.1016/j.nano.2018.03.006. [Epub ahead of print] PubMed PMID: 29626524.
  41. Ivanova D, Zhelev Z, Getsov P, Nikolova B, Aoki I, Higashi T, Bakalova R. Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect. Redox Biol. 2018 Jun;16:352-358. doi:10.1016/j.redox.2018.03.013. Epub 2018 Mar 20. PubMed PMID: 29597144; PubMed Central PMCID: PMC5953218. (IF:7.126, HL:2.8)
  42. Getsov P, Zhelev Z, Aoki I, Bakalova R. New Hypothesis and Alternative Approach for Imaging Neuronal Function and Metabolic Activity Based on Redox-Status. Balkan Med J. 2018 Mar 28. doi: 10.4274/balkanmedj.2018.0286. [Epub ahead of print] PubMed PMID: 29588266. (IF: 0.887, HL: 3.4)
  43. Ni R, Ji B, Ono M, Sahara N, Zhang MR, Aoki I, Nordberg A, Suhara T, Higuchi M. Comparative in-vitro and in-vivo quantifications of pathological tau deposits and their association with neurodegeneration in tauopathy mouse models. J Nucl Med. 2018 Jun;59(6):960-966. doi: 10.2967/jnumed.117.201632. Epub 2018 Feb 1. PubMed PMID: 29419480. (IF: 6.646, HL: 7.8, 2016)
  44. Sato K, Nitta N, Aoki I, Imai T, Shimokawa T. Repeated photon and C-ion irradiations in vivo have different impact on alteration of tumor characteristics. Sci Rep. 2018 Jan 23;8(1):1458. doi: 10.1038/s41598-018-19422-x. PubMed PMID: 29362374; PubMed Central PMCID: PMC5780469. (IF: 4.259, HL: 2.0, 2016)
  45. Ishikawa A, Tokunaga M, Maeda J, Minamihisamatsu T, Shimojo M, Takuwa H, Ono M, Ni R, Hirano S, Kuwabara S, Ji B, Zhang MR, Aoki I, Suhara T, Higuchi M, Sahara N. In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510. J Alzheimers Dis. 2018;61(3):1037-1052. doi: 10.3233/JAD-170509. PubMed PMID: 29332041. (IF: 3.731, HL: 4.5, 2016)
  46. Ogi H, Nitta N, Tando S, Fujimori A, Aoki I, Fushiki S, Itoh K. Longitudinal Diffusion Tensor Imaging Revealed Nerve Fiber Alterations in Aspm Mutated Microcephaly Model Mice. Neuroscience. 2018 Feb 10;371:325-336. doi:10.1016/j.neuroscience.2017.12.012. Epub 2017 Dec 16. PubMed PMID: 29253521. (IF: 3.277, HL: 9.2, 2016)
  47. Sawada K, Aoki I. Biphasic aspect of sexually dimorphic ontogenetic trajectory of gyrification in the ferret cerebral cortex. Neuroscience. 2017 Nov 19;364:71-81. doi: 10.1016/j.neuroscience.2017.09.015. Epub 2017 Sep 19. PMID: 28935238.
  48. Nakamura M, Shibata S, Yamasaki T, Ueno M, Nakanishi I, Matsumoto KI, Kamada T, Yamada KI, Aoki I. Feasibility of magnetic resonance redox imaging at low magnetic field: comparison at 1 T and 7 T. Am J Transl Res. 2017 Oct 15;9(10):4481-4491. eCollection 2017. PubMed PMID: 29118910; PubMed Central PMCID: PMC5666057. (IF: 2.829, HL: 2.5, 2016)
  49. Morishita K, Okamoto Y, Murayama S, Usui K, Ohashi E, Hirai G, Aoki I, Karasawa S. Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes. Langmuir. 2017 Aug 8;33(31):7810-7817. doi:10.1021/acs.langmuir.7b01126. Epub 2017 Jul 24. PubMed PMID: 28678510. (IF: 3.833, HL: 8.1, 2016)
  50. Luo Y, Fujita H, Nedelescu H, Biswas MS, Sato C, Ying S, Takahashi M, Akita K, Higashi T, Aoki I, Sugihara I. Lobular homology in cerebellar hemispheres of humans, non-human primates and rodents: a structural, axonal tracing and molecular expression analysis. Brain Struct Funct. 2017 Aug;222(6):2449-2472. doi: 10.1007/s00429-017-1436-9. Epub 2017 May 15. Review. PubMed PMID: 28508291. (IF: 4.698, HL: 3.2, 2016)
  51. Sato K, Kerever A, Kamagata K, Tsuruta K, Irie R, Tagawa K, Okazawa H, Arikawa-Hirasawa E, Nitta N, Aoki I, Aoki S. Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain. Acta Radiol Open. 2017 Apr 17;6(4):2058460117703816. doi: 10.1177/2058460117703816. eCollection 2017 Apr. PubMed PMID: 28491462; PubMed Central PMCID: PMC5405886. (IF: 2.011, HL: 8.0, 2016)
  52. Kokuryo D, Aoki I, Yuba E, Kono K, Aoshima S, Kershaw J, Saga T. Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon ion irradiation. Transl Res. 2017 Jul;185:24-33. doi:10.1016/j.trsl.2017.04.001. Epub 2017 Apr 21. PubMed PMID: 28482173. (IF: 4.652, HL: 3.6, 2016)
  53. Shiraishi K, Wang Z, Kokuryo D, Aoki I, Yokoyama M. A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood-brain barrier (BBB) permeability for macromolecules in cerebral ischemia-reperfusion injury. J Control Release. 2017 May 10;253:165-171. doi: 10.1016/j.jconrel.2017.03.020. Epub 2017 Mar 18. PubMed PMID: 28322975. (IF: 7.786, HL: 6.7, 2016)
  54. Kim J-H, Eguchi H, Umemura M, Sato I, Yamada S, Hoshino Y, Masuda T, Aoki I, Sakurai K, Yamamoto M, and Ishikawa Y. Magnetic metal complex-conducting copolymer core-shell nanoassemblies for single-drug anticancer platform, NPG Asia Materials. 2017 9;e367. Doi: 10.1038/am.2017.29. (IF: 9.157, HL: 3.0, 2016)
  55. Sawada K, Aoki I. Age-dependent sexually-dimorphic asymmetric development of the ferret cerebellar cortex. Symmetry. 2017 Mar;9(40). doi: 10.3390/sym9030040.
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  123. Matsumura S, Aoki I, Saga T, Shiba K. A tumor-environment-responsive nanocarrier that evolves its surface properties upon sensing matrix metalloproteinase-2 and initiates agglomeration to enhance T₂ relaxivity for magnetic resonance imaging. Mol Pharm. 2011 Oct 3;8(5):1970-4. doi: 10.1021/mp2001999. Epub 2011 Sep 16. PubMed PMID: 21899281.
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  125. Tomizawa A, Ishii I, Zhelev Z, Aoki I, Shibata S, Kitada M, Bakalova R. Carbamoyl-PROXYL-enhanced MRI detects very small disruptions in brain vascular permeability induced by dietary cholesterol. Biochim Biophys Acta. 2011 Dec;1810(12):1309-16. doi: 10.1016/j.bbagen.2011.06.011. Epub 2011 Jun 29. PubMed PMID: 21767608.
  126. Tomizawa A, Hadjidekov G, Ishii I, Bakalova R, Zhelev Z, Aoki I, Saga T, Kitada M. Nitroxide derivatives for imaging of hypercholesterolemia-induced kidney dysfunction and assessing the effectiveness of antilipidemic drugs. Mol Pharm. 2011 Oct 3;8(5):1962-9. doi: 10.1021/mp200087v. Epub 2011 Aug 15. PubMed PMID: 21744874.
  127. Saito S, Aoki I, Sawada K, Suhara T. Quantitative assessment of central nervous system disorder induced by prenatal X-ray exposure using diffusion and manganese-enhanced MRI. NMR Biomed. 2012 Jan;25(1):75-83. doi: 10.1002/nbm.1715. Epub 2011 Apr 28. PubMed PMID: 21538637.
  128. Autio JA, Kershaw J, Shibata S, Obata T, Kanno I, Aoki I. High b-value diffusion-weighted fMRI in a rat forepaw electrostimulation model at 7 T. Neuroimage. 2011 Jul 1;57(1):140-8. doi: 10.1016/j.neuroimage.2011.04.006. Epub 2011 Apr 12. PubMed PMID: 21504797.
  129. Saito S, Aoki I, Sawada K, Sun XZ, Chuang KH, Kershaw J, Kanno I, Suhara T. Quantitative and noninvasive assessment of prenatal X-ray-induced CNS abnormalities using magnetic resonance imaging. Radiat Res. 2011 Jan;175(1):1-9. doi: 10.1667/RR2134.1. Epub 2010 Nov 10. PubMed PMID: 21175341.
  130. Jin YN, Inubushi M, Masamoto K, Odaka K, Aoki I, Tsuji AB, Sagara M, Koizumi M, Saga T. Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model. Gene Ther. 2012 Aug;19(8):836-43. doi:10.1038/gt.2011.128. Epub 2011 Sep 15. PubMed PMID: 21918549.
  131. Yao R, Natsume Y, Saiki Y, Shioya H, Takeuchi K, Yamori T, Toki H, Aoki I, Saga T, Noda T. Disruption of Tacc3 function leads to in vivo tumor regression. Oncogene. 2012 Jan 12;31(2):135-48. doi: 10.1038/onc.2011.235. Epub 2011 Jun 20. PubMed PMID: 21685933.
  132. Hasegawa S, Koshikawa-Yano M, Saito S, Morokoshi Y, Furukawa T, Aoki I, Saga T. Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging. Int J Cancer. 2011 May 1;128(9):2138-46. doi: 10.1002/ijc.25547. PubMed PMID: 20617513.
  133. Hasegawa S, Saito S, Takanashi J, Morokoshi Y, Furukawa T, Saga T, Aoki I. Evaluation of ferritin-overexpressing brain in newly developed transgenic mice. Magn Reson Imaging. 2011 Feb;29(2):179-84. doi: 10.1016/j.mri.2010.08.013. Epub 2010 Dec 3. PubMed PMID: 21129877.
  134. Sawada K, Sun X-Z, Fukunishi K, Kahsima M, Saito S, Aoki I, Sakata-Haga H, Fukui Y. Development of corticocortical long associative fibers in cynomolgus monkey fetal cerebrum analyzed using DTI: its relation to sulcal formation. Advanced Studies in Biology. 2011 Apr;3(3):133-150. doi:10.12988/asb. http://www.m-hikari.com/asb/asb2011/asb1-4-2011/sawadaASB1-4-2011.pdf
  135. Kono K, Nakashima S, Kokuryo D, Aoki I, Shimomoto H, Aoshima S, Maruyama K, Yuba E, Kojima C, Harada A, Ishizaka Y. Multi-functional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy. Biomaterials. 2011 Feb;32(5):1387-95. doi: 10.1016/j.biomaterials.2010.10.050. Epub 2010 Nov 19. PubMed PMID: 21093041.
  136. Zhelev Z, Bakalova R, Aoki I, Gadjeva V, Kanno I. Imaging of cancer by redox-mediated mechanism: a radical diagnostic approach. Mol Biosyst. 2010 Dec;6(12):2386-8. doi: 10.1039/c0mb00113a. Epub 2010 Oct 8. PubMed PMID: 20936212.
  137. Matsumoto K, Aoki I, Nakanishi I, Matsumoto A, Nyui M, Endo K, Anzai K. Distribution of hydrogen peroxide-dependent reaction in a gelatin sample irradiated by carbon ion beam. Magn Reson Med Sci. 2010;9(3):131-40. PubMed PMID: 20885086.
  138. Kaida S, Cabral H, Kumagai M, Kishimura A, Terada Y, Sekino M, Aoki I, Nishiyama N, Tani T, Kataoka K. Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model. Cancer Res. 2010 Sep 15;70(18):7031-41. doi: 10.1158/0008-5472.CAN-10-0303. Epub 2010 Aug 4. PubMed PMID: 20685894.
  139. Hasegawa Y, Kinoh H, Iwadate Y, Onimaru M, Ueda Y, Harada Y, Saito S, Furuya A, Saegusa T, Morodomi Y, Hasegawa M, Saito S, Aoki I, Saeki N, Yonemitsu Y. Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-β gene. Mol Ther. 2010 Oct;18(10):1778-86. doi: 10.1038/mt.2010.138. Epub 2010 Jul 6. PubMed PMID: 20606645; PubMed Central PMCID: PMC2951556.
  140. Kokuryo D, Kimura Y, Obata T, Yamaya T, Kawamura K, Zhang MR, Kanno I, Aoki I. A small animal holding fixture system with positional reproducibility for longitudinal multimodal imaging. Phys Med Biol. 2010 Jul 21;55(14):4119-30. doi: 10.1088/0031-9155/55/14/011. Epub 2010 Jul 5. PubMed PMID: 20601770.
  141. Zhelev Z, Matsumoto K, Gadjeva V, Bakalova R, Aoki I, Zheleva A, Anzai K. EPR signal reduction kinetic of several nitroxyl derivatives in blood in vitro and in vivo. Gen Physiol Biophys. 2009 Dec;28(4):356-62. PubMed PMID: 20097958.
  142. Sawada K, Sun XZ, Fukunishi K, Kashima M, Saito S, Sakata-Haga H, Sukamoto T, Aoki I, Fukui Y. Ontogenetic pattern of gyrification in fetuses of cynomolgus monkeys. Neuroscience. 2010 May 19;167(3):735-40. doi:10.1016/j.neuroscience.2010.02.045. Epub 2010 Feb 26. PubMed PMID: 20219641.
  143. Inoue Y, Aoki I, Mori Y, Kawai Y, Ebisu T, Osaka Y, Houri T, Mineura K, Higuchi T, Tanaka C. Detection of necrotic neural response in super-acute cerebral ischemia using activity-induced manganese-enhanced (AIM) MRI. NMR Biomed. 2010 Apr;23(3):304-12. doi: 10.1002/nbm.1464. PubMed PMID: 19950123.
  144. Jo J, Aoki I, Tabata Y. Design of iron oxide nanoparticles with different sizes and surface charges for simple and efficient labeling of mesenchymal stem cells. J Control Release. 2010 Mar 19;142(3):465-73. doi: 10.1016/j.jconrel.2009.11.014. Epub 2009 Nov 22. PubMed PMID: 19932720.
  145. Kawai Y, Aoki I, Umeda M, Higuchi T, Kershaw J, Higuchi M, Silva AC, Tanaka C. In vivo visualization of reactive gliosis using manganese-enhanced magnetic resonance imaging. Neuroimage. 2010 Feb 15;49(4):3122-31. doi: 10.1016/j.neuroimage.2009.11.005. Epub 2009 Nov 10. PubMed PMID: 19909819.
  146. Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I. Nitroxyl radicals for labeling of conventional therapeutics and noninvasive magnetic resonance imaging of their permeability for blood-brain barrier: relationship between structure, blood clearance, and MRI signal dynamic in the brain. Mol Pharm. 2009 Mar-Apr;6(2):504-12. doi: 10.1021/mp800175k. PubMed PMID: 19718801.
  147. Matsumoto K, Nagata K, Yamamoto H, Endo K, Anzai K, Aoki I. Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam. Magn Reson Med. 2009 May;61(5):1033-9. doi: 10.1002/mrm.21958. PubMed PMID: 19253380.
  148. Sawada K, Sun XZ, Fukunishi K, Kashima M, Sakata-Haga H, Tokado H, Aoki I, Fukui Y. Developments of sulcal pattern and subcortical structures of the forebrain in cynomolgus monkey fetuses: 7-tesla magnetic resonance imaging provides high reproducibility of gross structural changes. Brain Struct Funct. 2009 Sep;213(4-5):469-80. doi: 10.1007/s00429-009-0204-x. Epub 2009 Feb 12. PubMed PMID: 19214566.
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  150. Bakalova R, Zhelev Z, Aoki I, Masamoto K, Mileva M, Obata T, Higuchi M, Gadjeva V, Kanno I. Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects. Bioconjug Chem. 2008 Jun;19(6):1135-42. doi: 10.1021/bc700431c. Epub 2008 May 22. PubMed PMID: 18494515.
  151. Aung W, Hasegawa S, Koshikawa-Yano M, Obata T, Ikehira H, Furukawa T, Aoki I, Saga T. Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging. Gene Ther. 2009 Jul;16(7):830-9. doi: 10.1038/gt.2009.55. Epub 2009 May 21. PubMed PMID: 19458649.
  152. Bakalova R, Zhelev Z, Aoki I, Kanno I. Designing quantum-dot probes. Nat Photonics, 2007, 1(9): 487-489. doi:10.1038/nphoton.2007.150.
  153. Bakalova R, Zhelev Z, Aoki I, Ohba H, Imai Y, Kanno I. Silica-shelled single quantum dot micelles as imaging probes with dual or multimodality. Anal Chem. 2006 Aug 15;78(16):5925-32. PubMed PMID: 16906742.​
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