原著論文
2023
1-(N,N-Dialkylcarbamoyl)-1,1-difluoromethanesulfonyl ester as a stable and effective precursor for neopentyl labeling group with astatine-211. I. Sasaki, M. Tada, Z. Liu, M. Tatsuta, T. Okura, M. Aoki, K. Takahashi, N. S. Ishioka, Sh. Watanabe, H. Tanaka, Organic and Biomolecular Chemistry, 21, 7467-7472, 2023. [DOI: 10.1039/D3OB00944K]
Radioactive isotope separation with 3D-printed flow-based device. S. Obata, Y. Sugo, H. Manabe, Y. Arima, K. Toda, N. S. Ishioka, M. Mori, S. Ohira, Analytical Sciences, 39, 671–677, 2023. [DOI: 10.1007/s44211-022-00254-9]
Comparative evaluation of radionuclide therapy using 90Y and 177Lu. H. Hanaoka, K. Hashimoto, Sa. Watanabe, S. Matsumoto, T. Sakashita, Sh. Watanabe, N. S. Ishioka, K. Endo, Annals of Nuclear Medicine, 37, 52-59, 2023 [DOI: 10.1007/s12149-022-01803-y]
2022
Corrosion behavior of iron-chrome alloys in liquid bismuth. T. Takai, T. Furukawa, S. Watanabe, N.S. Ishioka, Mechanical Enginnering Journal, 9, 21-00397, 2022 [DOI: 10.1299/mej.21-00397]
Copper-mediated radioiodination and radiobromination via aryl boronic precursor and its application to 125I/77Br-labeled prostate-specific membrane antigen imaging probes. Y. Kondo, H. Kimura, I. Sasaki, S. Watanabe, Y. Ohshima, Y. Yagi, Y. Hattori, M. Koda, H. Kawashima, H. Yasui, N. S. Ishioka, Bioorg. Med. Chem., 69, 116915, 2022 [DOI: 10.1016/j.bmc.2022.116915]
Organic cation transporter 3 mediates the non-norepinephrine transporter driven uptake of meta-[211At]astato-benzylguanidine. Y. Ohshima, I. Sasaki, S. Watanabe, T. Sakashita, T. Higashi, N.S. Ishioka, Nucl. Med. Biol., 112-113, 44-51 ,2022 [DOI: 10.1016/j.nucmedbio.2022.06.005]
Highly efficient separation of ultratrace radioactive copper using a flow electrolysis cell. Y. Sugo, S. Ohira, H. Manabe, Y. Maruyama, N. Yamazaki, R. Miyachi, K. Toda, Noriko S. Ishioka, M. Mori, ACS Omega, 7: 15779–15785, 2022 [DOI: 10.1021/acsomega.2c00828]
Enhancing the accumulation level of 3-[18F]fluoro-L-α-methyltyrosine in tumors by preloading probenecid. A. Kanai, H. Hanaoka, A. Yamaguchi, I. Mahendra, C. Palangka, Y. Ohshima, T. Higuchi, Y. Tsushima, Nucl. Med. Biol., 104-105, 47-52, 2022 [DOI: 10.1016/j.nucmedbio.2021.11.006]
2021
Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows. Y. Nagao, M. Yamaguchi, S. Watanabe, N. S. Ishioka, N. Kawachi, H. Watabe. Journal of Instrumentation 16: C12031, 2021 [DOI: 10.1088/1748-0221/16/12/C12031]
Rapid Flow-Based System for Separation of Radioactive Metals by Selective Complex Formation. Y. Sugo, R. Miyachi, S. Obata, Y. Maruyama, H. Manabe, M. Mori, N.S. Ishioka, K. Toda, S. Ohira, Anal. Chem., 93: 17069-17075, 2021 [DOI: 10.1021/acs.analchem.1c03866]
Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy. T. Sakashita, S. Matsumoto, S. Watanabe, H. Hanaoka, Y. Ohshima, Y. Ikoma, N. Ukon, I. Sasaki, T. Higashi, T. Higuchi, Y. Tsushima, N. S. Ishioka, EJNMMI Phys., 8: 80, 2021. [DOI: 10.1186/s40658-021-00425-z]
Enhancing the therapeutic effect of 2-211At-astato-α-methyl-L-phenylalanine with probenecid loading. H. Hanaoka, Y. Ohshima, H. Suzuki, I. Sasaki, T. Watabe, K. Ooe, S. Watanabe, N. S. Ishioka, Cancers, 13, 5514, 2021 [DOI: 10.3390/cancers13215514]
Neopentyl glycol as a scaffold to provide radiohalogenated theranostic pairs of high in vivo stability. H. Suzuki, Y. Kaizuka, M. Tatsuta, H. Tanaka, N. Washiya, Y. Shirakami, K. Ooe, A. Toyoshima, T. Watabe, T. Teramoto, I. Sasaki, S. Watanabe, N.S. Ishioka, J. Hatazawa, T. Uehara, Y. Arano, J. Med. Chem., in press, 2021, [DOI: 10.1021/acs.jmedchem.1c01147]
Re-evaluations of Zr-DFO Complex Coordination Chemistry for the Estimation of Radiochemical Yields and Chelator-to-Antibody Ratios of 89Zr Immune-PET Tracers. R. Imura, H. Ida, I. Sasaki, N. S. Ishioka, S. Watanabe, Molecules, 26: 4977 [DOI: 10.3990/molecules26164977]
Adsorption temperature of volatile astatine species formed via dry distillation in a glass tube. I. Nishinaka, K. Washiyama, K. Hashimoto, J Radioanal Nucl Chem, 329: 1459-1465, 2021 [DOI :10.1007/s10967-021-07879-6]
Absorbed dose simulation of meta-211At-astato-benzylguanidine using pharmacokinetics of 131I-MIBG and a novel dose conversion method, RAP, T. Sakashita, S. Watanabe, H. Hanaoka, Y. Ohshima, Y. Ikoma, N. Ukon, I. Sasaki, T. Higashi, T. Higuchi, Y. Tsushima, N. S. Ishioka, Ann Nucl Med 35: 121-131, 2021 [DOI: 10.1007/s12149-020-01548-6]
Separation of astatine from irradiated lead targets based on dry distillation in a glass test tube, I. Nishinaka, K. Hashimoto, J Radioanal Nucl Chem 327: 869-875, 2021 [DOI: 10.1007/s10967-020-07546-2]
2020
A Simple Isolation of 211At using an Anion-Exchange Spin Column Method, S. Watanabe, I. Sasaki, S. Watanabe, T. Higashi, N. S. Ishioka, J Radioanal Nucl Chem 326: 1399-1404, 2020 [DOI: 10.1007/s10967-020-07422-z]
Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model, Y. Ohshima, H. Suzuki, H. Hanaoka, I. Sasaki, S. Watanabe, H. Haba, Y. Arano, Y. Tsushima, N. S. Ishioka, Nucl Med Biol 90-91: 15-22, 2020 [DOI: 10.1016/j.nucmedbio.2020.08.003]
Preparation of no-carrier-added 211At solutions by a simple dry distillation method in the 209Bi(4He, 2n)211At reaction, I. Nishinaka, N. S. Ishioka, S. Watanabe, I. Sasaki, M. A. Azim, J Radioanal Nucl Chem 326: 743-751, 2020 [DOI: 10.1007/s10967-020-07308-0]
Analytical method for the determination of 211At using an α-scintillation camera system and thin-layer chromatography, M. Segawa, I. Nishinaka, Y. Toh, M. Maeda, J Radioanal Nucl Chem 326: 773-778, 2020 [DOI: 10.1007/s10967-020-07353-9]
Electrodialytic handling of radioactive metal ions for preparation of tracer reagents, Y. Sugo, R. Miyachi, Y. Maruyama, S. Ohira, M. Mori, N. S. Ishioka, K. Toda, Anal Chem 92: 14953-14958, 2020 [DOI: 10.1021/acs.analchem.0c02456]
2019
Immuno-PET imaging for non-invasive assessment of cetuximab accumulation in non-small cell lung cancer, A. Yamaguchi, A. Achmad, H. Hanaoka, Y. D. Heryanto, A. Bhattarai, Ratianto, E. Khongorzul, R. Shintawati, A. A. P. Kartamihardja, A. Kanai, Y. Sugo, N. S. Ishioka, T. Higuchi, Y. Tsushima, BMC Cancer. 2019;19:1000. [DOI: 10.1186/s12885-019-6238-4]
Speciation of astatine reacted with oxidizing and reducing reagents by thin layer chromatography: formation of volatile astatine, I. Nishinaka, K. Hashimoto, H. Suzuki, J. Radioanal. Nucl. Chem. 322, 2003-2009 (2019) [DOI: 10.1007/s10967-019-06900-3]
Preclinical Evaluation of the Acute Radiotoxicity of the α-Emitting Molecular-targeted Therapeutic Agent 211At-MABG for the Treatment of Malignant Pheochromocytoma in Normal Mice, Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Kotaro Nagatsu, Katsuyuki Minegishi, Noriko S. Ishioka, Hiroshi Ito, Keiichiro Yoshinaga, and Tatsuya Higashi, Transl Oncol 2019;12(7):879-888. [DOI: 10.1016/j.tranon.2019.04.008]
Novel 18F-Labeled α-Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging, Hirofumi Hanaoka, Yasuhiro Ohshima, Aiko Yamaguchi, Hiroyuki Suzuki, Noriko S. Ishioka, Tetsuya Higuchi, Yasushi Arano, and Yoshito Tsushima, Mol Pharm. 2019;16(8):3609-3616. [DOI: 10.1021/acs.molpharmaceut.9b00446]
Anti-tumor Effects and Potential Therapeutic Response Biomarkers in α-Emitting meta-211At-Astato-Benzylguanidine Therapy for Malignant Pheochromocytoma Explored by RNA-sequencing, Ohshima Y, Kono N, Yokota Y, Watanabe S, Sasaki I, Ishioka NS, Sakashita T, Arakawa K, Theranostics, 2019;9(6):1538-1549. [DOI: 10.7150/thno.30353]
A convenient and reproducible method for the synthesis of astatinated 4-[211At]astato-L-phenylalanine via electrophilic desilylation, S. Watanabe, M. Anwar-Ul Azim, I. Nishinaka, I. Sasaki, Y. Ohshima, K. Yamada, N. S. Ishioka, Org Biomol Chem, 2019;17:165-171. [DOI: 10.1039/C8OB02394H]
Measurements of the excitation functions of radon and astatine isotopes from 7Li-induced reactions with 209Bi for development of a 211Rn–211At generator, Maeda E, Yokoyama A, Taniguchi T, Washiyama K, Nishinaka I, J Radioanal Nucl Chem, 323, 921-926 (2020) [DOI: 10.1007/s10967-019-06990-z]
2018
Rational evaluation of the therapeutic effect and dosimetry of auger electrons for radionuclide therapy in a cell culture model, Shinohara A, Hanaoka H, Sakashita T, Sato T, Yamaguchi A, Ishioka NS, Tsushima Y., Ann Nucl Med. 2018;32(2):114-122. [DOI: 10.1007/s12149-017-1225-9]
Antitumor effects of radionuclide treatment using α-emitting meta-211At-astato-benzylguanidine in a PC12 pheochromocytoma model, Ohshima Y, Sudo H, Watanabe S, Nagatsu K, Tsuji AB, Sakashita T, Ito YM, Yoshinaga K, Higashi T, Ishioka NS., Eur J Nucl Med Mol Imaging. 2018;45(6):999-1010. [DOI: 10.1007/s00259-017-3919-6]
Improvement and Optimization of Clinically Potent Positron Emitter 76Br Isolation Using the Dry Distillation Approach for its Future Automation, S. Watanabe, A. Shimada, S. Watanabe, H. Hanaoka, Noriko S. Ishioka, Trans Mater Res Soc Jpn 2018;43(4):219-222. [DOI: 10.14723/tmrsj.43.219]
Thin layer chromatography for astatine and iodine in solutions prepared by dry distillation, I. Nishinaka, K. Hashimoto, H. Suzuki, J Radioanal Nucl Chem 2018;318(2):897-905 [DOI: 10.1007/s10967-018-6088-6]
2017
Production of iodine radionuclides using 7Li ion beams, I. Nishinaka, A. Yokoyama, K. Washiyama, H. Makii, and K. Hashimoto, J Radioanal Nucl Chem 2017;314(3):1947–1965. [DOI: 10.1007/s10967-017-5525-2]
Role of Multichance Fission in the Description of Fission-Fragment Mass Distributions at High Energies, Hirose K, Nishio K, Tanaka S, Léguillon R, Makii H, Nishinaka I, Orlandi R, Tsukada K, Smallcombe J, Vermeulen MJ, Chiba S, Aritomo Y, Ohtsuki T, Nakano K, Araki S, Watanabe Y, Tatsuzawa R, Takaki N, Tamura N, Goto S, Tsekhanovich I, Andreyev AN, Phys Rev Lett. 2017;119(22):222501. [DOI: 10.1103/PhysRevLett.119.222501]
The 95Zr(n, γ)96Zr Cross Section from the Surrogate Ratio Method and Its Effect on s-process Nucleosynthesis, S. Q. Yan, Z. H. Li, Y. B. Wang , K. Nishio, M. Lugaro, A. I. Karakas, H. Makii, P. Mohr, J. Su, Y. J. Li, I. Nishinaka, K. Hirose, Y. L. Han, R. Orlandi, Y. P. Shen, B. Guo , S. Zeng, G. Lian, Y. S. Chen, and W. P. Liu, Astrophys J 2017;848(2) 98-1-8. [DOI: 10.3847/1538-4357/aa8c74]
2016
Efficacy of system L amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma, Yasuhiro Ohshima, Kyoichi Kaira, Aiko Yamaguchi, Noboru Oriuchi, Hideyuki Tominaga, Shushi Nagamori, Yoshikatsu Kanai, Takehiko Yokobori,Tatsuya Miyazaki, Takayuki Asao, Yoshito Tsushima, Hiroyuki Kuwano and Noriko S. Ishioka, Cancer Sci 107: 1499-1505, 2016 [DOI: 10.1111/cas.13021]
Medical application of radiohalogenated peptides:synthesis and in vitro evaluation of F(p-131I)KCCYSL for targeting HER2 in vitro, I. Sasaki, S. Watanabe, Y. Ohshima, Y. Sugo, K. Yamada, H. Hanaoka, andN. S. Ishioka, Pept Sci 2015, 243-246 (2016)
Simultaneous analysis of silicon and boron dissolved in water by combination of electrodialytic salt removal and ion-exclusion chromatography with corona charged aerosol detection, M. Mori, K. Sagara, K. Arai, N. Nakatani, S. Ohira, K. Toda, H.Itabashi, D. Kozaki, Y. Sugo, Sh. Watanabe, N. S. Ishioka and K. Tanaka, J Chromatogr A 1431, 131-137 (2016) [DOI: 10.1016/j.chroma.2015.12.064]
2015
Preparation and evaluation of an astatine-211-labeled sigma receptor ligand for alpha radionuclidetherapy, K. Ogawa, Y. Mizuno, K. Washiyama, K. Shiba, N. Takahashi, T. Kozaka,Sh. Watanabe, A. Shinohara, A. Odani, Nucl. Med. Biol. 42, 875-879 (2015) [DOI: 10.1016/j.nucmedbio.2015.07.001]
Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator, E. Maeda, A. Yokoyama, T. Taniguchi, K. Washiyama, I. Nishinaka, J. Radioanal. Nucl. Chem. 303, 1465-1468 (2015) [DOI: 10.1007/s10967-014-3586-z]
Development of a widely usable amino acid tracer : 76Br-α-methyl-phenylalanine for tumor PET Imaging, H. Hanaoka, Y.Ohshima, Y. Suzuki, A. Yamaguchi, Sh. Watanabe, T. Uehara, S. Nagamori,Y. Kanai, N. S. Ishioka, Y. Tsushima, K. Endo and Y. Arano, J Nucl.Med., 56(5), 791-797 (2015) [DOI: 10.2967/jnumed.114.152215]
In vitro studies on cellular binding and stability of 64Cu-labeledpeptide for tumor imaging, Y. Sugo, Y. Ohshima, I. Sasaki and N. S.Ishioka, Pept Sci 2014, 303-306 (2015).
Exploring of peptides with affinity to HER2 from random peptidelibraries using radioisotope; Random hexapeptide libraries with fixedamino acid sequence at 1 and 2 positions, I. Sasaki, H. Hanaoka, K.Yamada, Sh. Watanabe, Y. Sugo, Y. Ohshima, H. Suzuki and N. S. Ishioka, Pept Sci 2014, 257-260 (2015).
Production and separation of astatine isotopes in the 7Li + natPb reaction. I. Nishinaka, A. Yokoyama, K. Washiyama, E. Maeda, S. Watanabe, K. Hashimoto, N. S. Ishioka, H. Makii, A. Toyoshima, N. Yamada, R. Amano, J. Radioanal. Nucl. Chem., 304, 1077-1083 (2015) [DOI: 10.1007/s10967-015-3975-y]
α-Radiation Effect on Solvent Extraction of Minor Actinide. Y. Sugo, Y. Sasaki, M. Taguchi, N. S. Ishioka, J. Radioanal. Nucl. Chem., 303, 1381-1384 (2015) [DOI: 10.1007/s10967-014-3494-2]
Lutetium-177 complexation of DOTA and DTPA in the presence of competing metals. S. Watanabe, K. Hashimoto, N.S. Ishioka, J. Radioanal. Nucl. Chem. 303, 1519-1521 (2015) [DOI: 10.1007/s10967-014-3590-3]
Production of highly purified no-carrier-added 177Lu for radioimmunotherapy. Satoshi Watanabe, Kazuyuki Hashimoto, Shigeki Watanabe, Yasuhiko Iida, Hirofumi Hanaoka, Keigo Endo, Noriko S. Ishioka, J. Radioanal. Nucl. Chem., 303, 935-940 (2015) [DOI: 10.1007/s10967-014-3534-y]
2014
First Measurement of the Radionuclide Purity of the Therapeutic Isotope 67Cu Produced by 68Zn(n,x) Reaction Using natC(d,n) Neutrons. Nozomi Sato, Kazuaki Tsukada, Satoshi Watanabe, Noriko S. Ishioka, Masako Kawabata, Hideya Saeki, Yasuki Nagai, Tadahiro Kin, Futoshi, Minato, Nobuyuki Iwamoto, Osamu Iwamoto, J. Phys. Soc. Jpn. 83, 073201 (2014) [DOI: 10.7566/JPSJ.83.073201]
Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer. M. Toyoda, K. Kaira*, Y. Ohshima*, N.S. Ishioka, M. Shino, K. Sakakura, Y. Takayasu, K. Takahashi, H. Tominaga, N. Oriuchi, S. Nagamori, Y. Kanai, T. Oyama, K. Chikamatsu, Br. J. Cancer, 110, 2506-2513 (2014) [DOI: 10.1038/bjc.2014.178] * These authors equally contributed to this work.
Biological significance of fluorine-18-α-methyltyrosine (FAMT) uptake on PET in patients with oesophageal cancer. S. Suzuki*, K. Kaira*, Y. Ohshima*, N.S. Ishioka, M. Sohda, T. Yokobori, T. Miyazaki, N. Oriuchi, H. Tominaga, Y. Kanai, N. Tsukamoto, T. Asao, Y. Tsushima, T. Higuchi, T. Oyama, H. Kuwano, Br. J. Cancer, 110, 1985-1991 (2014) [DOI: 10.1038/bjc.2014.142] * These authors equally contributed to this work.
Synthesis and in vitro evaluation of 64Cu-labeled peptide for tumor imaging. Y. Sugo, I. Sasaki, S. Watanabe, Y. Ohshima, N.S. Ishioka, Pept Sci 2013, 355-358 (2014)
2013
Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine. E. R. Balkin, D. K. Hamlin, K. Gagnon, M.-K. Chyan, S. Pal, S. Watanabe, D. S. Wilbur, Appl. Sci., 3, 636-655 (2013) [DOI: 10.3390/app3030636]
Synthesis of radiohalogen-labeled peptides with high affinity to HER2/neu receptor. I. Sasaki, K. Yamada, S. Watanabe, H. Hanaoka, Y. Sugo, H. Oku, N.S. Ishioka, Pept Sci 2012, 157-160 (2013)
2012
Biological and evaluation of 3-[18F]fluoro-α-methyl-D-tyrosine (D-[18F]FAMT) as a novel amino acid tracer for positron emission tomography. Y. Ohshima, H. Hanaoka, H. Tominaga, Y. Kanai, K. Kaira, A. Yamaguchi, S. Nagamori, N. Oriuchi, Y. Tsushima, K. Endo, N.S. Ishioka, Ann. Nucl. Med., 27, 314-324 (2013) [DOI: 10.1007/s12149-013-0687-7]
Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer. K. Kaira, Y. Sunose*, Y. Ohshima*, N.S. Ishioka, K. Arakawa, T. Ogawa, N. Sunaga, K. Shimizu, H. Tominaga, N. Oriuchi, H. Itoh, S. Nagamori, Y. Kanai, A. Yamaguchi, A. Segawa, M. Ide, M. Mori, T. Oyama, I. Takeyoshi, BMC Cancer, 13, 482 (2013) [DOI: 10.1186/1471-2407-13-482] * These authors equally contributed to this work.
Synthesis and in vivo evaluation of radiohalogen-labeled antitumor cyclic peptides. K. Yamada, S. Watanabe, Y. Ohshima, H. Hanaoka, N. Tsukui, C. Takano, A. Yamaguchi, H. Oku, N.S. Ishioka, Pept Sci 2011, 287-290 (2012)
2011
Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography. A. Achmad, H. Hanaoka, H. Yoshioka, S. Yamamoto, H. Tominaga, T. Araki, Y. Ohshima, N. Oriuchi, K. Endo. Cancer Sci 103: 600-605, 2012 [DOI: 10.1111/j.1349-7006.2011.02166.x]
Electron absorbed fractions and S values in a voxel-based mouse phantom, A. Mohammadi and S. Kinase, Radioisotopes 60, 505-512(2011). [DOI: 10.3769/radioisotopes.60.505]
Influence of voxel size on specific absorbed fractions and S values in a mouse voxel phantom, A. Mohammadi and K. Kinase, Radiat Prot Dosim 143(2-4), 258-263 (2011) [DOI: 10.1093/rpd/ncq391]
Preparation and biological evaluation of 3-[76Br]bromo-α-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors. Y. Ohshima, H. Hanaoka, S. Watanabe, Y. Sugo, S. Watanabe, H. Tominaga, N. Oriuchi, K. Endo, N.S. Ishioka. Nucl. Med. Biol., 38, 857-865 (2011) [DOI: 10.1016/j.nucmedbio.2011.02.001 ]
Monte Carlo Simulations of Photon Specific Absorbed Fractions in a Mouse Voxel Phantom. A. Mohammadi and S. Kinase, Prog Nucl Sci Technol 1: 126-129, 2011
2010
PET imaging of norepinephrine transporter-expressing tumors using 76Br-meta-bromobenzylguanidine. S. Watanabe, H. Hanaoka, J. X. Liang, Y. Iida, K. Endo, and N. S. Ishioka, J Nucl Med 51: 1472-1479, 2010 [DOI: 10.2967/jnumed.110.075465]
Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with 64Cu-labeled trastuzumab PET. P. Paudyal, B. Paudyal, H. Hanaoka, N. Oriuchi, Y. Iida, H. Yoshioka, H. Tominaga, S. Watanabe, S. Watanabe, N. S. Ishioka and K. Endo. Cancer Sci 101: 1045-1050, 2010 [DOI: 10.1111/j.1349-7006.2009.01480.x]
Tracing cadmium from culture to spikelet: non-invasive imaging and quantitative characterization of absorption, transport and accumulation of cadmium in an intact rice plant, S. Fujimaki, N. Suzui, N.S. Ishioka, N. Kawachi, S. Ito, M. Chino, S. Nakamura. Plant Physiol 152: 1796-1806, 2010 [DOI: 10.1104/pp.109.151035]
S. Fujimaki, S. Ishii, N.S. Ishioka (2010) Non-invasive imaging and analyses of transport of nitrogen nutrition in intact plants using a positron-emitting tracer imaging system (PETIS). In: Ohyama T, Sueyoshi K (eds) Nitrogen Assimilation in Plants. Research Signpost, Kerala, India
11CO2と植物用ボジトロンイメージング装置を用いたダイズ植物の根粒に対する光合成産物移行のリアルタイム解析, 伊藤小百合, 鈴井伸郎, 河地有木, 石井里美, 石岡典子, 藤巻秀. Radioisotopes 59: 145-154, 2010 [DOI: 10.3769/radioisotopes.59.145]
2009
Real-time imaging of nitrogen fixation in an intact soybean plant with nodules using 13N-labeled nitrogen gas. S. Ishii, N. Suzui, S. Ito, N. S. Ishioka, N. Kawachi, N. Ohtake, T. Ohyama and S. Fujimaki. Soil Sci Plant Nutr 55: 660-666, 2009 [DOI: 10.1111/j.1747-0765.2009.00403.x]
Evaluation of 64Cu-labeled DOTA-D-Phe1-Tyr3-octreotide (64Cu-DOTA-TOC) for imaging somatostatin receptor-expressing tumors. H. Hanaoka, H. Tominaga, K. Yamada, P. Paudyal, Y. Iida, S. Watanabe, B. Paudyal, T. Higuchi, N. Oriuchi, and K. Endo Ann. Nucl. Med., 23: 559-567. 2009 [DOI: 10.1007/s12149-009-0274-0]
Chelating ion-exchange methods for the preparation of no-carrier-added 64Cu. S. Watanabe, S. Watanabe, J. X. Liang, H. Hanaoka, K. Endo, and N. S. Ishioka. Nucl Med Biol 36: 587-590, 2009 [DOI: 10.1016/j.nucmedbio.2009.04.005]
Production of no-carrier-added 64Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer. S. Watanabe, Y. Iida, N. Suzui, T. Katabuchi, S. Ishii, N. Kawachi, H. Hanaoka, S. Watanabe, S. Matsuhashi, K. Endo, N. Ishioka. J Radioanal Nucl Chem 280: 199-205, 2009 [DOI: 10.1007/s10967-008-7443-9]
52Fe translocation in barley as monitored by a positron-emitting tracer imaging system (PETIS): evidence for the direct translocation of Fe from roots to young leaves via phloem. T. Tsukamoto, H. Nakanishi, H. Uchida, S. Watanabe, S. Matsuhashi, S. Mori, N. K. Nishizawa. Plant Cell Physiol 50: 48-57, 2009 [DOI: 10.1093/pcp/pcn192]
2008
Deoxymugineic acid increases Zn translocation in Zn-deficient rice plants. M. Suzuki, T. Tsukamoto, H. Inoue, S. Watanabe, S. Matsuhashi, M. Takahashi, H. Nakanishi, S. Mori, N. K. Nishizawa. Plant Mol Biol 66: 609-617, 2008 [DOI: 10.1007/s11103-008-9292-x]
Analysis of NO3 interception of the parasitic angiosperm Orobanche spp. using a positron-emitting tracer imaging system and 13NO-3: A new method for the visualization and quantitative analysis of the NO3 interception ratio. N. Kawachi, S. Fujimaki, K. Sakamoto, N. S. Ishioka, S. Matsuhashi, H. Sekimoto. Soil Sci Plant Nutr 54: 408-416, 2008 [DOI: 10.1111/j.1747-0765.2008.00252.x]
Production of 67Cu via the 68Zn(p,2p)67Cu reaction and recovery of 68Zn target. T. Katabuchi, S. Watanabe, N. Ishioka, Y. Iida, H. Hanaoka, K. Endo, S. Matsuhashi. J Radioanal Nucl Chem 277: 467-470, 2008 [DOI: 10.1007/s10967-007-7144-9]
2007
Production of endohedral 133Xe-higher fullerenes by ion implantation. S. Watanabe, T. Katabuchi, N. S. Ishioka, S. Matsuhashi, H. Muramatsu. J Radioanal Nucl Chem 272: 467-469, 2007 [DOI: 10.1007/s10967-007-0605-3]
Synthesis of Endohedral 133Xe-Fullerenol by Using Higher Fullerene. S. Watanabe, T. Katabuchi, N. S. Ishioka, S. Matsuhashi. J Nucl Radiochem Sci 8: 105-107, 2007 [DOI: 10.14494/jnrs2000.8.105]
Mutational reconstructed ferric chelate reductase confers enhanced tolerance in rice to iron deficiency in calcareous soil. Y. Ishimaru, S. Kim, T. Tsukamoto, H. Oki, T. Kobayashi, S. Watanabe, S. Matsuhashi, M. Takahashi, H. Nakanishi, S. Mori, N. K. Nishizawa. Proc Natl Acad Sci U.S.A. 104: 7373-7378, 2007 [DOI: 10.1073/pnas.0610555104]
2006
52Mn translocation in barley monitored using a positron-emitting tracer imaging system. T. Tsukamoto, H. Nakanishi, S. Kiyomiya, S. Watanabe, S. Matsuhashi, N. K. Nishizawa, S. Mori. Soil Sci Plant Nutr 52: 717-725, 2006 [DOI: 10.1111/j.1747-0765.2006.00096.x]
Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley. M. Suzuki, M. Takahashi, T. Tsukamoto, S. Watanabe, S. Matsuhashi, J. Yazaki, N. Kishimoto, S. Kikuchi, H. Nakanishi, S. Mori, N. K. Nishizawa. Plant J 48: 85-97, 2006 [DOI: 10.1111/j.1365-313X.2006.02853.x]
A new visualization technique for the study of the accumulation of photoassimilates in wheat grains using [11C]CO2. S. Matsuhashi, S. Fujimaki, H. Uchida, N. S. Ishioka, T. Kume. Appl Radiat Isot 64: 435-440, 2006 [DOI: 10.1016/j.apradiso.2005.08.020]
Kinetic analysis of carbon-11-labeled carbon dioxide for studying photosynthesis in a leaf using positron emitting tracer imaging system. N. Kawachi, K. Sakamoto, S. Ishii, S. Fujimaki, N. Suzui, N. S. Ishioka, S. Matsuhashi. IEEE Trans Nucl Sci 53: 2991-2997, 2006 [DOI: 10.1109/TNS.2006.881063]
Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+. Y. Ishimaru, M. Suzuki, T. Tsukamoto, K. Suzuki, M. Nakazono, T. Kobayashi, Y. Wada, S. Watanabe, S. Matsuhashi, M. Takahashi, H. Nakanishi, S. Mori, N. K. Nishizawa. Plant J 45: 335-346, 2006 [DOI: 10.1111/j.1365-313X.2005.02624.x]
2005
Conversion of endohedral 133Xe-fullerene to endohedral 133Xe-fullerenol to be used in nuclear medicine. S. Watanabe, N. S. Ishioka, T. Sekine, H. Kudo, H. Shimomura, H. Muramatsu, T. Kume. J Radioanal Nucl Chem 266: 499-502, 2005 [DOI: 10.1007/s10967-005-0938-8]
Quantitative modeling of photoassimilate flow in an intact plant using the Positron Emitting Tracer Imaging System (PETIS). S. Matsuhashi, S. Fujimaki, N. Kawachi, K. Sakamoto, N. S. Ishioka, T. Kume. Soil Sci Plant Nutr 51: 417-423, 2005 [DOI: 10.1111/j.1747-0765.2005.tb00047.x]
Input-output analysis of in vivo photoassimilate translocation using Positron-Emitting Tracer Imaging System (PETIS) data. A. J. Keutgen, N. Keutgen, S. Matsuhashi, C. Mizuniwa, T. Ito, T. Fujimura, N. S. Ishioka, S. Watanabe, A. Osa, T. Sekine, H. Uchida, A. Tsuji, S. Hashimoto. J Exp Bot 56: 1419-1425, 2005 [DOI: 10.1093/jxb/eri143]
2003
Dose dependence of the production yield of endohedral 133Xe-fullerene by ion implantation. S. Watanabe, N. S. Ishioka, H. Shimomura, H. Muramatsu, T. Sekine. Nucl Instrum Methods Phys Res Sect B 206: 399-402, 2003 [DOI: 10.1016/S0168-583X(03)00771-7]
Production of endohedral 133Xe-fullerene by ion implantation. S. Watanabe, N. S. Ishioka, T. Sekine, A. Osa, M. Koizumi, H. Shimomura, K. Yoshikawa, H. Muramatsu. J Radioanal Nucl Chem 255: 495-498, 2003 [DOI: 10.1023/A:1022524214082]
Quick and reversible inhibition of soybean root nodule growth by nitrate involves a decrease in sucrose supply to nodules. H. Fujikake, A. Yamazaki, N. Ohtake, K. Sueyoshi, S. Matsuhashi, T. Ito, C. Mizuniwa, T. Kume, S. Hashimoto, N. S. Ishioka, S. Watanabe, A. Osa, T. Sekine, H. Uchida, A. Tsuji, T. Ohyama. J Exp Bot 54: 1379-1388, 2003 [DOI: 10.1093/jxb/erg147]
2002
Transfer function analysis of positron-emitting tracer imaging system (PETIS) data. N. Keutgen, S. Matsuhashi, C. Mizuniwa, T. Ito, T. Fujimura, N. S. Ishioka, S. Watanabe, T. Sekine, H. Uchida, S. Hashimoto. Appl Radiat Isot 57: 225-233, 2002 [DOI: 10.1016/S0969-8043(02)00077-5]
Effects of anion channel blockers on xylem nitrate transport in barley seedlings. T. Kawachi, C. Nishijo, H. Fujikake, S. Abdel-Latif, N. Ohtake, K. Sueyoshi, T. Ohyama, N. Shigeta-Ishioka, S. Watanabe, A. Osa, T. Sekine, S. Matsuhashi, T. Ito, C. Mizuniwa, T. Kume, S. Hashimoto, H. Uchida, A. Tsuji. Soil Sci Plant Nutr 48: 271-277, 2002 [DOI: 10.1080/00380768.2002.10409200]
2001
Effect of radiation-degraded chitosan on plants stressed with vanadium. L. Xuan Tham, N. Nagasawa, S. Matsuhashi, N. S. Ishioka, T. Ito, T. Kume. Radiat Phys Chem 61: 171-175, 2001 [DOI: 10.1016/S0969-806X(00)00388-1]
Production of positron emitters of metallic elements to study plant uptake and distribution. S. Watanabe, N. S. Ishioka, A. Ose, M. Koizumi, T. Sekine, S. Kiyomiya, H. Nakanishi, S. Mori. Radiochim Acta 89: 853-858, 2001 [DOI: 10.1524/ract.2001.89.11-12.853]
Rapid N transport to pods and seeds in N-deficient soybean plants. N. Ohtake, T. Sato, H. Fujikake, K. Sueyoshi, T. Ohyama, N. S. Ishioka, S. Watanabe, A. Osa, T. Sekine, S. Matsuhashi, T. Ito, C. Mizuniwa, T. Kume, S. Hashimoto, H. Uchida, A. Tsuji. J Exp Bot 52: 277-283, 2001 [DOI: 10.1093/jxb/52.355.277]
18F used as tracer to study water uptake and transport imaging of a cowpea plant. T. M. Nakanishi, K. Tanoi, H. Yokota, D. J. Kang, R. Ishii, N. S. Ishioka, S. Watanabe, A. Osa, T. Sekine, S. Matsuhashi, T. Ito, T. Kume, H. Uchida, A. Tsuji. J Radioanal Nucl Chem 249: 503-507, 2001 [DOI: 10.1023/A:1013217425209]
Real time visualization of 13N-translocation in rice under different environmental conditions using positron emitting tracer imaging system. S. Kiyomiya, H. Nakanishi, H. Uchida, A. Tsuji, S. Nishiyama, M. Futatsubashi, H. Tsukada, N. S. Ishioka, S. Watanabe, T. Ito, C. Mizuniwa, A. Osa, S. Matsuhashi, S. Hashimoto, T. Sekine, S. Mori. Plant Physiol 125: 1743-1753, 2001 [DOI: 10.1104/pp.125.4.1743]
Light activates H215O flow in rice: Detailed monitoring using a positron-emitting tracer imaging system (PETIS). S. Kiyomiya, H. Nakanishi, H. Uchida, S. Nishiyama, H. Tsukada, N. S. Ishioka, S. Watanabe, A. Osa, C. Mizuniwa, T. Ito, S. Matsuhashi, S. Hashimoto, T. Sekine, A. Tsuji, S. Mori. Physiol Plant 113: 359-367, 2001 [DOI: 10.1034/j.1399-3054.2001.1130309.x]
Ion chromatographic analysis of selected free amino acids and cations to investigate the change of nitrogen metabolism by herbicide stress in soybean (Glycine max). M. H. Jia, N. Keutgen, S. Matsuhashi, C. Mitzuniwa, T. Ito, T. Fujimura, S. Hashimoto. J Agric Food Chem 49: 276-280, 2001 [DOI: 10.1021/jf990344c]
Vanadium uptake and an effect of vanadium treatment on 18F-labeled water movement in a cowpea plant by positron emitting tracer imaging system (PETIS). J. Furukawa, H. Yokota, K. Tanoi, S. Ueoka, S. Matsuhashi, N. S. Ishioka, S. Watanabe, H. Uchida, A. Tsuji, T. Ito, T. Mizuniwa, A. Osa, T. Sekine, S. Hashimoto, T. M. Nakanishi. J Radioanal Nucl Chem 249: 495-498, 2001 [DOI: 10.1023/A:1013276224300]
Real-time [11C]methionine translocation in barley in relation to mugineic acid phytosiderophore biosynthesis. N. Bughio, H. Nakanishi, S. Kiyomiya, S. Matsuhashi, N. S. Ishioka, S. Watanabe, H. Uchida, A. Tsuji, A. Osa, T. Kume, S. Hashimoto, T. Sekine, S. Mori. Planta 213: 708-715, 2001 [DOI: 10.1007/s004250100552]
2000
Visualization of 15O-water flow in tomato and rice in the light and dark using a positron-emitting tracer imaging system (PETIS). S. Mori, S. Kiyomiya, H. Nakanishi, N. S. Ishioka, S. Watanabe, A. Osa, S. Matsuhashi, S. Hashimoto, T. Sekine, H. Uchida, S. Nishiyama, H. Tsukada, A. Tsuji. Soil Sci Plant Nutr 46: 975-979, 2000 [DOI: 10.1080/00380768.2000.10409163]
1999
Production of radioactive endovascular stents by implantation of 133Xe ions. S. Watanabe, A. Osa, T. Sekine, N. S. Ishioka, M. Koizumi, T. Kojima, A. Hasegawa, M. Yoshii, E. Okamoto, K. Aoyagi, A. Miyajima, R. Nagai. Appl Radiat Isot 51: 197-202, 1999 [DOI: 10.1016/S0969-8043(98)00180-8]
T. Sekine, H. Matsuoka. Production and utilization of radioisotopes. Proc. 3rd workshop on neutron science project -- Science and Technology in the 21st century opened by intense spallation neutron source--; 207, 1999
Analysis of nitrate absorption and transport in non-nodulated and nodulated soybean plants with 13NO3- and 15NO3-. T. Sato, N. Ohtake, T. Ohyama, N. S. Ishioka, S. Watanabe, A. Osa, T. Sekine, H. Uchida, A. Tsuji, S. Matsuhashi. Radioisotopes 48: 450-458, 1999 [DOI: 10.3769/radioisotopes.48.450]
Visualizing real time [11C]methionine translocation in Fe-sufficient and Fe-deficient barley using a Positron Emitting Tracer Imaging System (PETIS). H. Nakanishi, N. Bughio, S. Matsuhashi, N. S. Ishioka, H. Uchida, A. Tsuji, A. Osa, T. Sekine, T. Kume, S. Mori. J Exp Bot 50: 637-643, 1999 [DOI: 10.1093/jxb/50.334.637]
Mössbauer spectroscopy of 133Cs following the decay of 133Xe atoms implanted in metals. H. Muramatsu, H. Ishii, E. Tanaka, M. Misawa, H. Ito, T. Miura, S. Muto, M. Koizumi, A. Osa, T. Sekine, M. Yanaga. J Radioanal Nucl Chem 239: 251-255, 1999 [DOI: 10.1007/BF02349492]
13N-nitrate uptake sites and rhizobium-infectible region in a single root of common bean and soybean. H. Matsunami, Y. Arima, K. Watanabe, N. S. Ishioka, S. Watanabe, A. Osa, T. Sekine, H. Uchida, A. Tsuji, S. Matsuhashi, T. Itoh, T. Kume. Soil Sci Plant Nutr 45: 955-962, 1999 [DOI: 10.1080/00380768.1999.10414345]
The accelerator production of molybdenum-99. R. M. Lambrecht, T. Sekine, H. V. Ruiz. Production technologies for molybdenum-99 and technetium-99m. IAEA-TECDOC-1065, 75. 1999
Alice predictions on the accelerator production of molybdenum-99. R. M. Lambrecht, T. Sekine, H. V. Ruiz. Appl Radiat Isot 51: 177-182, 1999 [DOI: 10.1016/S0969-8043(98)00171-7]
Comments on the cross sections of 186Re in the 186W(p, n) and 186W(d, 2n) reactions in connection to the paper given by Z. H. Zhu et al. and correction of the calculated yields of 186Re in the 186W(p, n) reaction. N. S. Ishioka, T. Sekine, R. M. Lambrecht. J Radioanal Nucl Chem 241: 383-383, 1999 [DOI: 10.1007/BF02347480]
Production of positron emitters and application of their labeled compounds to plant studies. N. S. Ishioka, H. Matsuoka, S. Watanabe, A. Osa, M. Koizumi, T. Kume, S. Matsuhashi, T. Fujimura, A. Tsuji, H. Uchida, T. Sekine. J Radioanal Nucl Chem 239: 417-421, 1999 [DOI: 10.1007/BF02349523]
1998
Calibration and interpretation of Mössbauer isomer shift of the 81-keV transition in 133Cs. H. Muramatsu, E. Tanaka, H. Ishii, H. Ito, M. Misawa, T. Miura, Y. Fujita, K. Omata, S. Muto, M. Koizumi, A. Osa, T. Sekine, M. Yanaga, K. Endo, H. Nakahara, M. Fujioka. Phys Rev B 58: 11313, 1998 [DOI: 10.1103/PhysRevB.58.11313]
A simple retardation system for low-energy implantation of mass-separated radioactive ions. H. Muramatsu, H. Ishii, E. Tanaka, A. Osa, M. Koizumi, T. Sekine, T. Miura, M. Fujioka. Nucl Instrum Methods Phys Res Sect B 134: 126-135, 1998 [DOI: 10.1016/S0168-583X(98)80042-6]
N. S. Ishioka, T. Sekine, H. Matsuoka, S. Watanabe, A. Osa, M. Koizumi, T. Kume, S. Matsuhashi, T. Fujimura, H. Uchida, A. Tsuji, L. X. Tham, V. H. Dang. Application of positron emitters to studies on plants. Proc. of 1997 Workshop on the Utilization of Research Reactors; 349, 1998
著書・総説・解説
Dosimetry in therapy using radiopharmaceuticals, T. Sakashita, N. Ukon, T. Higashi, in T. Shirai, T. Nishio and K. Sato (eds.), ADVANCES IN ACCELERATORS AND MEDICAL PHYSICS, Elsevier Inc., 315-325, 2023
加速器を利用した新規有用アイソトープの製造とライフサイエンス分野への応用研究、渡辺茂樹、Isotope News 770: 50-51, 2020
α線放出核種を用いた RI 内用療法と放射線生物学、坂下哲哉、横田裕一郎、大島康宏、放射線生物研究 55(3): 229-247, 2020
原子力教科書放射線利用「医療における放射線利用」松橋信平、石岡典子、（株）オーム社、（2011年出版）
内分泌画像検査・診断マニュアル「褐色細胞腫の新しいPET診断薬：76Br-MBBG」石岡典子、渡邉茂樹、花岡宏史、（株）診断と治療社（2011年出版）
がん診断・治療に向けた新しいRI標識薬剤の開発.渡辺茂樹,石岡典子 放射線と産業 129,27-31,2011
76Br-MBBGを用いた褐色細胞腫のPETイメージング.渡辺茂樹,石岡典子,Isotope News 680:2-6,2010
イオンビームによる有用RIの生成とライフサイエンスへの応用.石岡典子.Isotope News 673:14-18,2010
日本のRI研究開発の現状.石岡典子.原子力eye 55(7):20-23,2009
生命科学分野で役立つポジトロン放出核種を用いた非侵襲的計測技術,石岡典子,藤巻秀.放射線と産業,124,21-26(2009).
土壌中からのカドミウムの除去技術（ファイトレメディエーション）の実用化を目指した研究におけるポジトロンイメージング技術の貢献.中村進一,茅野充男,藤巻秀,鈴井伸郎,石岡典子,河地有木,松橋信平.放射線と産業117:9-14,2008
AVFサイクロトロンによる植物研究用ポジトロン放出核種標識化合物の製造.石岡典子.放射線と産業80:11-15,1998