加齢やストレスは関節リウマチなどの免疫病だけでなく、脳血管障害や循環器障害、認知症など現代の高齢化社会では避けては通れない慢性炎症性疾患を引き起こします。私たちのこれまでの研究で、慢性炎症は病原性免疫細胞が局所的に特定の血管周囲に微小炎症を誘導し、血管を突破することで様々な臓器や組織へと侵入して引き起こされることがわかってきました。しかし、病気のもととなる微小炎症を早期に発見・除去する予防策は存在していません。この課題を解決するために、高感度量子センサなどの量子技術を用いて微小炎症の場所を可視化（添付の図参照、ここではAuナノクラスターを北海道大学大学院地球環境科学研究院 小西克明先生、七分勇勝先生との共同研究として使用）し、どのようにして慢性炎症が始まり進行していくのか明らかにしていきます。
関連リンク：Murakami Labホームページ
チームメンバー
村上 正晃 チームリーダー
田中 勇希 主任研究員 大木 出 主任研究員
小沢 聡士 業務補助員
北條 慎太郎 客員研究員 久保田 晋平 客員研究員
田井中 一貴 客員研究員 竹内 雄一 客員研究員
渡慶次 学 客員研究員 長谷部 理恵 客員研究員
北條 慎太郎 客員研究員 南 雅文 客員研究員
山崎 剛士 客員研究員
佐藤 一紀 実習生
2023年度の成果
7. Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto, Seiichiro Naito, Yuki Tanaka, Izuru Ohki, Yuta Shinohara, Norimasa Iwasaki, Akihiko Yoshimura, Jing-Jing Jiang, Daisuke Kamimura, Shintaro Hojyo, Shimpei I. Kubota, Shigeru Hashimoto, and Masaaki Murakami, Computer simulation of an IL-6 dependent rheumatoid arthritis model in F759 mice, Int Immunol., in press
6. Shiina Matsuyama, Reiji Yamamoto, Kaoru Murakami, Nobuhiko Takahashi, Rieko Nishi, Asuka Ishii, Junko Kobayashi, Nobuya Abe, Kumiko Tanaka, Jing-Jing Jiang, Tadafumi Kawamoto, Toshihiko Iwanaga, Yuta Shinohara, Takeshi Yamasaki, Izuru Ohki, Shintaro Hojyo, Rie Hasebe, Shimpei Kubota, Noriyuki Hirata, Daisuke Kamimura, Shigeru Hashimoto, Yuki Tanaka, and, Masaaki Murakami, GM-CSF promotes the survival of peripheral-derived myeloid cells in the CNS for pain-induced relapse of neuroinflammation, Journal of Immunology, in press
5. Hajime Senjo, Shinpei Harada, Shimpei Kubota, Yuki Tanaka, Takahiro Tateno, Zixuan Zhang, Satomi Okada, Xuanzhong Chen, Ryo Kikuchi, Naoki Miyashita, Masahiro Onozawa, Hideki Goto, Tomoyuki Endo, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Masaaki Murakami, Takanori Teshima, and Daigo Hashimoto, Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT, Blood, in press
4. Hiroaki Kida, Jing-Jing Jiang, Yuichiro Matsui, Ikuko Takahashi, Rie Hasebe, Makoto Kondoh, Yasuhiko Nishio, Kinya Nishida, Yoshihiro Matsuno, Tsukasa Oikawa, Shimpei Kubota, Shintaro Hojyo, Norimasa Iwasaki, Shigeru Hashimoto, Yuki Tanaka, and Masaaki Murakami, Dupuytren’s contracture-associated SNPs increase SFRP4 expression in nonimmune cells including fibroblasts to enhance inflammation development, Int Immunol., 31 January 2023, doi:10.1093/intimm/dxad004, ()Article)
3. Takeshi Yamasaki, Noriyuki Nagata, Toru Atsumi, Rie Hasebe, Yuki Tanaka, Izuru Ohki, Shimpei Kubota, Yuta Shinohara, Yong Bin Teoh, Nozomu Yokoyama, Noboru Sasaki, Kensuke Nakamura, Hiroshi Ohta, Takehiko Katsurada, Yoshihiro Matsuno, Shintaro Hojyo, Shigeru Hashimoto, Mitsuyoshi Takiguchi, Masaaki Murakami, Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients, Int Immunol. 2023 Mar 18, doi: 10.1093/intimm/dxad006. ()Article)
2. Fayrouz Naim, Rie Hasebe, Shintaro Hojyo, Yukatsu Shichibu, Asuka Ishii, Yuki Tanaka, Kazuki Tainaka, Shimpei I. Kubota, Katsuaki Konishi and Masaaki Murakami, In situ Microinflammation Detection Using Gold Nanoclusters and a Tissue-clearing Method, bio-plotocol, Vol 13, Iss 7, Apr 5, 2023 DOI: 10.21769/BioProtoc.4644, (Article)
1. Tianyue Zhai, Takashi Mitamura, Lei Wang, Shimpei I Kubota, Masaaki Murakami, Shinya Tanaka, Hidemichi Watari, Combination therapy with bevacizumab and CCR2 inhibitor for women with ovarian cancer: in vivo validation study, Cancer Medicine, 22 February 2023, doi:10.1002/cam4.5674, (Article)
2022年度の成果
8. Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, Hiromi Yamamoto, Shuhei Sakakibara, Chikako Ono, Yumi Itoh, Tommy Terooatea, Kazuo Yamashita, Toru Okamoto, Noritaka Hashii, Akiko Ishii-Watabe, Noah Butler, Yoshiharu Matsuura, Hisatake Matsumoto, Shinya Otsuka, Kei Hiraoka, Takanori Teshima, Masaaki Murakami, and Tomohiro Kurosaki, Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees, Journal of Experimental Medicine, 13 December 2022, doi:10.1084/jem.20221786, ()Article)
7. Nobuya Abe, Michihiro Kono, Michihito Kono , Takayuki Katsuyama, Kazumasa Ohmura, Taiki Sato, Kohei Karino, Yuichiro Fujieda, Masaru Kato, Rie Hasebe, Masaaki Murakami, Tatsuya Atsumi, Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis: a preliminary observational study, Frontiers in Immunology, doi:10.3389/fimmu.2022.1066916, ()Article)
6. Kaoru Murakami, Sumio Iwasaki, Satoshi Oguri, Kumiko Tanaka, Rigel Suzuki, Kasumi Hayasaka, Shinichi Fujisawa, Chiaki Watanabe, Satoshi Konno, Isao Yokota, Takasuke Fukuhara, Masaaki Murakami, Takanori Teshimach, SARS-CoV-2 Omicron detection by antigen tests using saliva, Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100109, ()Article)
5. Nobuya Abe, Masato Tarumi, Yuichiro Fujieda, Nobuhiko Takahashi, Kohei Karino, Mona Uchida, Michihito Kono, Yuki Tanaka, Rie Hasebe, Masaru Kato, Olga Amengual, Yoshiyuki Arinuma, Kenji Oku, Wakiro Sato, Khin Khin Tha, Miwako Yamasaki, Masahiko Watanabe, Tatsuya Atsumi, Masaaki Murakami, Pathogenic neuropsychiatric effect of stress-induced microglial interleukin 12/23 axis in systemic lupus erythematosus, Ann. Rheum. Dis., doi:10.1136/ard-2022-222566, () (ArticleHYPERLINK "https://www.igm.hokudai.ac.jp/neuroimmune/files/Abe_N_Ann_Rheum_Dis_2022.pdf" )
4. Nobuya Abe, Michihito Kono, Michihiro Kono, Naoki Ohnishi, Tomoya Sato, Masato Tarumi, Masaru Yoshimura, Taiki Sato, Kohei Karino, Yuka Shimizu, Yuichiro Fujieda, Masaru Kato, Rie Hasebe, Kenji Oku, Masaaki Murakami, Tatsuya Atsumi. Glycogen synthase kinase 3β/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO, British Journal of Haematology. 2022. 196(5):1194-1204.
3. Takashi Kudo, Daigo Nakazawa, Kanako Watanabe-Kusunoki, Masatoshi Kanda, Satoka Shiratori-Aso, Nobuya Abe, Saori Nishio, Jun-Ichiro Koga, Sari Iwasaki, Takahiro Tsuji, Yuichiro Fukasawa, Miwako Yamasaki, Masahiko Watanabe, Sakiko Masuda, Utano Tomaru, Masaaki Murakami, Yasuaki Aratani, Akihiro Ishizu, Tatsuya Atsumi, Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody–Associated Vasculitis, Arthritis & Rheumatology, 29 July 2022, doi: 10.1002/art.42314()Article)
2. Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa, Fuminori Kawano, Yoshinobu Ohira, Tadafumi Kawamoto, Fiona E. Yull, Timothy S. Blackwell, Junko Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, Nobuhiro Watanabe, Harumi Hotta, Toshihide Yamashita, Daisuke Kamimura, Yuki Tanaka, Masaaki Murakam, ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons. J. Exp. Med. May 2022, 219(6), doi: 10.1084/jem.20212019 ()Article)
1. Kevin J Tracey, Sangeeta Chavan, Masaaki Murakami, Introduction: Electronic Medicine in Immunology Special Issue Part 2, Int. Immunol., 29 July 2022, doi: 10.1093/intimm/dxab100 ()Article)