計測・線量評価部　生物線量評価グループ

研究内容

生物線量評価グループでは、放射線被ばくに伴う生物の染色体異常の発生頻度に基づく被ばく線量推計について、より実効的・効率的な評価手法の開発・研究を行っています。

一例としては、ディープラーニングを用いた自動染色体異常（二動原体染色体異常・染色体断片）解析システムの汎用化を目指し、画像判定手法の改良・最適化等の研究を行っています。加えて、染色体画像の関係機関とのオンライン共有及び判定を実現する体制構築にも取り組んでおり、被ばく患者が多数発生した際にも迅速に線量評価を行える環境整備に努めています。

  
​放射線被ばくによって生じた交換型染色体異常［転座染色体や二動原体染色体］※3色FISH法により検出
（左図：1番染色体・赤色；2番染色体・緑色；4番染色体・黄色、右図：対比線色・青色）

List of Papers

1. Akiyama M., Tominaga T., Takashima Y., Ishii K., Suto Y. Assessing the applicability of a modified replication banding protocol for the analysis of radiation-induced chromosomal aberrations in cultured human lymphocytes. Cytologia 89(1): 39-46; 2024. https://doi.org/10.1508/cytologia.89.39
2. Ishii K., Akiyama M., Kamimoto K., Kawai H., Suto Y. Application of automated scoring system of dicentric chromosome for biodosimetry. Cytologia 88(4): 281-282; 2023. https://doi.org/10.1508/cytologia.88.281
3. Abe Y., Takashima Y., Akiyama M., Tsuyama N., Kai T., Nakayama R., Goh V. S. T., Sugai-Takahashi M., Alkebsi L., Ishii K., Kudo K., Sakai A., Kurihara O., Miura T., Suto Y., Akashi M. A preliminary report on retrospective dose assessment by FISH translocation assay in FDNPP Nuclear Emergency Worker Study (NEWS).  Radiation Protection Dosimetry. 199(14): 1565–1571, 2023.  https://doi.org/10.1093/rpd/ncad053
4. Barquinero J-F., Abe Y., Aneva N., Endesfelder D., Georgieva D., Goh VST., Gregoire E., Hristova R., Lee Y., Martínez J-S., Meher P-K., Miura T., Port M., Pujol-Canadell M., Prieto-Rodriguez MJ., Seong K-M., Suto Y., Takebayashi K., Tsuyama N., Wojcik A., Yoon H-J., Abend M. RENEB Inter-Laboratory Comparison 2021: The FISH-Based Translocation Assay. Radiation Research 199(6): 583-590. https://doi.org/10.1667/RADE-22-00203.1
5. Endesfelder D., Oestreicher U., Bucher M., Beinke C., Siebenwirth C, Ainsbury E., Moquet J., Gruel G., Gregoire E., Martinez J.S., Vral A., Baeyens A., Valente M., Montoro A., Terzoudi G., Triantopoulou S., Pantelias A., Gil O. M., Prieto M.J., Domene M.M., Zafiropoulos D., Barquinero J.F., Pujol-Canadell M., Lumniczky K., Hargitai R., Kis E., Testa A., Patrono C., Sommer S., Hristova R., Kostova N., Atanasova M., Sevriukova O., Domínguez I., Pastor N., Güçlü I., Pajic J., Sabatier L., Brochard P., Tichy A., Milanova M., Finot F., Cuceu Petrenci C., Wilkins R.C., Beaton-Green L.A., Seong K.M., Lee Y., Lee Y.H., Balajee A.S., Maznyk N., Sypko T., Pham N.D., Tran T.M., Miura T., Suto Y., Akiyamam M., Tsuyama N., Abe Y., Goh V.S.T., Chua C.E.L., Abend M., Port M. RENEB Inter-Laboratory Comparison 2021: The Dicentric Chromosome Assay. Radiation Research 199(6): 556-570. https://doi.org/10.1667/RADE-22-00202.1
6. Suto Y., Tominaga T., Akiyama M., Hirai M. Revisiting Microscopic Observation of Chromosomal Aberrations in Cultured Human Peripheral Blood Lymphocytes at the Second Mitotic Division after Gamma Irradiation In Vitro. Cytologia 86(1): 67-77; 2021. https://doi.org/10.1508/cytologia.86.67
7. Suto Y., Tominaga T., Akiyama M., Hirai M. Cytogenetic Examination of Human Peripheral Blood Lymphocytes Cryopreserved after Gamma Irradiation: A Pilot Study. Cytologia 85(1): 71-77; 2020. https://doi.org/ 10.1508/cytologia.85.71
8. Jang S., Suto Y., Liu J., Liu Q., Zuo Y., Duy P. N., Miura T., Abe Y., Hamasaki K., Suzuki K., Kodama S. Capability of the ARADOS-WG-03 regional network for large-scale radiological and nuclear emergency situations in Asia. Radiation Protection Dosimetry 186(1): 139-142; 2019. https://doi.org/10.1093/rpd/ncy279
9. Suto Y., Gotoh T., Noda T., Akiyama M., Owaki M., Darroudi F., Hirai M. Assessing the applicability of FISH-based prematurely condensed dicentric chromosome assay in triage biodosimetry.  Health Phys 108(3): 371-376; 2015. https://doi.org/10.1097/hp.0000000000000182
10. Suto Y., Hirai M., Akiyama M., Kobashi G., Itokawa M., Akashi M., Sugiura N. Biodosimetry of restoration workers for Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Station accident. Health Phys 105(4): 366-373; 2013. https://doi.org/10.1097/hp.0b013e3182995e42