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量子生命科学研究所

量子神経マッピング制御チーム

掲載日：2025年4月1日更新
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量子神経キャッチ​

神経細胞、グリア細胞、血管など様々な機能をもつ脳の細胞群は、相互に支え合いながら恒常性を維持しています。私達は、量子計測技術（ナノ量子センサなど）を駆使して、脳の健全性を維持する脳細胞の複合的な相互作用メカニズムや、それらが破たんした時に生じる脳疾患メカニズムについて量子計測技術を駆使して調べています。ここで得られた知見を、多くの脳疾患の診断・治療法の開発につなげるように、日々努力しています。

 

田桑チームリーダー

 

 

 

 

 

チームリーダー　田桑 弘之

 

メンバー紹介

田桑　弘之　チームリーダー

高橋　真奈美　博士研究員
吉岡　正輝　博士研究員　
脇田　翔吾　実習生　（千葉大・院・医D２）
高田　彩加　研究員　（千葉大・院・量子D2）
半田　真理子　研究員　（千葉大・院・量子D1）
竹本　珠梨　QSTリサーチアシスタント　（千葉大・院・化学　M2）
大森　開生　QSTリサーチアシスタント　（千葉大・院・量子　M1）
神永　麻衣　QSTスチューデントリサーチャー（千葉大・院・量子　M1）

派遣職員（事務系1名と実験系2名）

南久松　丈晴　脳機能イメージング研究センター　技術員　（併任）

永島　圭介　専門業務員
正本　和人　協力研究員　（電気通信大・教授・情報理工学）
馬場　千聞　実習生　（電気通信大・院・情報理工学）

 

チームの研究について

研究の概要図

私達は、２光子励起レーザー顕微鏡を使って生きた動物の脳内の様々な細胞や病気の原因となるタンパク質を可視化して、脳の仕組みや認知症や脳卒中での疾患メカニズムを調べています。さらに、量子計測技術を生体脳実験に応用して、脳細胞の多様な状態を評価する方法を開発しています。

多様な脳細胞の図

上の画像は、2光子顕微鏡を使ってマウスの脳内から観察した実際の細胞や組織の画像です。ニューロンやグリア細胞、血管など様々な特徴を持った細胞がいることが分かります。生体脳イメージング技術を駆使することで、標的の細胞を数か月間何度でも繰り返し計測することができます。それは、学習前後や疾患前後、治療介入前後での細胞の状態や役割の変化をとらえることに役立ちます。

脳の病気の画像

さらに上の画像では、認知症の原因と考えられている凝集性のタンパク質を特殊な蛍光剤で標識してミクロレベルで可視化を行っています（これはQST独自の技術です）。このようなミクロな世界を観察する技術は、多様な細胞間の相互作用の理解に役立ち、脳の仕組みを明らかにできます。さらに病気の診断・治療方法の開発にも有効です。

このような技術を使って現在、主に以下の５つの課題に取り組んでいます。

1. 量子計測技術を生命科学や基礎医学に応用するための実験システムの開発
※1で開発した技術を以下の２．３．４に応用しています。
2. 免疫細胞の新規評価法を開発と認知症や脳卒中や癌の疾患メカニズムの解明
3. 脳微小領域の温度計測法の開発と脳卒中メカニズムの解明
4. 神経ネットワークの評価法の開発と脳機能の解明
5. 脳の水動態の評価系の開発と脳卒中への影響について

 

学生、若手研究者の方へ​​研究を心から楽しめる方や新しい生命現象にワクワクする方、私たちと一緒に研究しませんか？
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千葉大学 融合理工学府　量子生命科学コース（博士前期・後期課程）からも当チームの研究に参加できます。

 

 

チーム結成後（2022年以降）の表彰​

  1. 2025年  3月　千葉大学大学院「学府長賞」半田真理子　　
  2. 2024年12月　第54回千葉大学脳神経外科医会研究会「Best presentation賞（牧野賞）」吉岡正輝　
  3. 2024年10月　In Vivoイメージングフォーラム「最優秀ポスター賞」半田真理子
  4. 2024年  9月　第33回日本バイオイメージング学会「スカラーシップアウォード」半田真理子
  5. 2024年  9月　第33回日本バイオイメージング学会「スカラーシップアウォード」竹本珠梨　
  6. 2024年  3月　コニカミノルタ科学技術振興財団「コニカミノルタ画像科学奨励賞」高橋真奈美　
  7. 2023年11月　第32回日本バイオイメージング学会「ベストグラフィカルアブストラクト賞」半田真理子　
  8. 2023年  5月　量子生命科学会第5回大会「Best presentation 賞」高橋真奈美　
  9. 2022年12月　量子生命科学先端フォーラム2022「優秀発表賞」高橋真奈美

Publications​

  1. Neuronal deterioration associated with hyperexcitability under mild chronic cerebral hypoperfusion. Takuya Urushihata, Manami Takahashi, Masafumi Shimojo, Yuhei Takado, Nobuhiro Nitta, Yosuke Tajima, Kazuto Masamoto, Iwao Kanno, Yutaka Tomita, Naruhiko Sahara, Masaya Takahashi, Takayuki Obata, Hiroshi Ito, Tetsuro Yamashita, Tetsuya Suhara, Makoto Higuchi, Hiroyuki Takuwa*　J Cereb Blood Flow Metab. 2025 in press
  2. Imaging α-synuclein pathologies in animal models and patients with Parkinson‘s and related diseases. Endo H, Ono M, Takado Y, Matsuoka K, Takahashi M, Tagai K, Kataoka Y, Hirata K, Takahata K, Seki C, Kokubo N, Fujinaga M, Mori W, Nagai Y, Mimura K, Kumata K, Kikuchi T, Shimozawa A, Mishra SK, Yamaguchi Y, Shimizu H, Kakita A, Takuwa H, Shinotoh H, Shimada H, Kimura Y, Ichise M, Suhara T, Minamimoto T, Sahara N, Kawamura K, Zhang MR, Hasegawa M, Higuchi M.　Neuron. 2024 Aug 7;112(15):2540-2557.e8.
  3. Two-photon optogenetics-based assessment of neuronal connectivity in healthy and chronic hypoperfusion mice. Yoshioka M, Takahashi M, Kershaw J, Handa M, Takada A, Takuwa H*. Neurophotonics. 2024 Jul;11(3):035009. 
  4. Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model. Kudo T, Takuwa H*, Takahashi M, Urushihata T, Shimojo M, Sampei K, Yamanaka M, Tomita Y, Sahara N, Suhara T, Higuchi M.　iScience. 2023 Mar 5;26(4):106342
  5. Capillary responses to functional and pathological activations rely on the capillary states at rest. Suzuki H, Takeda H, Takuwa H, Ji B, Higuchi M, Kanno I, Masamoto K.　J Cereb Blood Flow Metab. 2023 Jun;43(6):1010-1024.
  6. Distribution of intraperitoneally administered deuterium-labeled water in aquaporin-4-knockout mouse brain after middle cerebral artery occlusion. Urushihata T, Takuwa H, Takahashi M, Kershaw J, Shibata S, Nitta N, Tachibana Y, Yasui M, Higuchi M, Obata T.　Front Neurosci. 2023 Jan 6;16:1071272.
  7. Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.　Tachida Y, Miura S, Muto Y, Takuwa H, Sahara N, Shindo A, Matsuba Y, Saito T, Taniguchi N, Kawaguchi Y, Tomimoto H, Saido T, Kitazume S. J Biol Chem. 2022 Jun;298(6):101880.
  8. MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice. Takado Yuhei, Takuwa Hiroyuki*, Kazuaki Sampei, Urushihata Takuya, Manami Takahashi, Shimojo Masafumi, Uchida Shoko, Nitta Nobuhiro, Shibata Sayaka, Nagashima Keisuke, Ochi Yoshihiro, Ono Maiko, Maeda Jun, Tomita Yutaka, Sahara Naruhiko, Jamie Near, Aoki Ichio, Shibata Kazuhisa, Higuchi Makoto. Journal of Cerebral Blood Flow & Metabolism, 2022, 197 – 212, DOI:10.1177/0271678X211045449
  9. Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI. Takuya Urushihata, Hiroyuki Takuwa, Manami Takahashi, Jeff Kershaw, Yasuhiko Tachibana, Nobuhiro Nitta, Sayaka Shibata, Masato Yasui, Makoto Higuchi, Takayuki Obata European radiology experimental, 5(1), 44, 2021, DOI:10.1186/s41747-021-00244-y
  10. Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model. Hideaki Sato, Yuhei Takado, Sakiko Toyoda, Masako Tsukamoto-Yasui, Keiichiro Minatohara, Hiroyuki Takuwa, Takuya Urushihata, Manami Takahashi, Masafumi Shimojo, Maiko Ono, Jun Maeda, Asumi Orihara, Naruhiko Sahara, Ichio Aoki, Sachise Karakawa, Muneki Isokawa, Noriko Kawasaki, Mika Kawasaki, Satoko Ueno, Mayuka Kanda, Mai Nishimura, Katsuya Suzuki, Akira Mitsui, Kenji Nagao, Akihiko Kitamura, Makoto Higuchi Science advances, 7(43), eabd5046, 2021, DOI:10.1126/sciadv.abd5046
  11. A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains Masafumi Shimojo,  Maiko Ono,  Hiroyuki Takuwa,  Masayuki Fujinaga,  Tatsuya Kikuchi,  Maki Okada,  Koki Mimura,  Yuji Nagai,  Chie Seki,  Masaki Tokunaga,  Jun Maeda,  Yuhei Takado,  Manami Takahashi,  Takeharu Minamihisamatsu,  Ming-Rong Zhang,  Yutaka Tomita,  Norihiro Suzuki,  Takafumi Minamimoto,  Anton Maximov,  Tetsuya Suhara,  Naruhiko Sahara,  Makoto Higuchi EMBO Journal, 40(22), e107757, 2021, DOI:10.15252/embj.2021107757  
  12. Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models Manabu Kubota, Yasuyuki Kimura, Masafumi Shimojo, Yuhei Takado, Joao M.N. Duarte, Hiroyuki Takuwa, Chie Seki, Hitoshi Shimada, Hitoshi Shinotoh, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Kenji Tagai, Takayuki Obata, Jin Nakahara, Yutaka Tomita, Masaki Tokunaga, Jun Maeda, Kazunori Kawamura, Ming-Rong Zhang, Masanori Ichise, Tetsuya Suhara, Makoto Higuchi JCBFM, J Cereb Blood Flow Metab, 2021, 2928-2943, Doi: 10.1177/0271678X211004150.
  13. Three-dimensional microvascular network reconstruction from in vivo images with adaptation of the regional inhomogeneity in the signal-to-noise ratio Sugashi Takuma, Hiroya Yuki, Tomoya Niizawa, Takuwa Hiroyuki, Kanno Iwao, Masamoto Kazuto Microcirculation, 28(5), e12697, 2021, DOI:10.1111/micc.12697
  14. Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin Yoko Ikoma, Hiroyuki Takuwa, Asuka Nishino, Jun Maeda, Kazunori Kawamura, Takayuki Obata, Ming-Rong Zhang, Makoto Higuchi, Tetsuya Suhara Annals of nuclear medicine, 955-965, 2021, DOI:10.1007/s12149-021-01633-4
  15. Time Series Tracking of Crebral Microvascular Adaptation to Hypoxia and Hyperoxia Imaged with Repeated In Vivo Two-Photon Microscopy. Takuma Sugashi, Tomoya Niizawa, Hiroki Suzuki, Hiroyuki Takuwa, Miyuki Unekawa, Yutaka Tomita, Iwao Kanno, Kazuto Masamoto Adv Exp Med Biol, 323-327, 2021. Doi: 10.1007/978-3-030-48238-1_51.
  16. Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons Nao Hatakeyama, Unekawa Miyuki, Juri Murata, Tomita Yutaka, Norihiro Suzuki, Jin Nakahara, Takuwa Hiroyuki, Kanno Iwao, Ko Matsu, Kenji F Tanaka, Masamoto Kazuto Journal of Cerebral Blood Flow & Metabolism, 2676-2689, 2021, DOI:10.1177/0271678X211010355
  17. High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies Kenji Tagai,  Maiko Ono,  Manabu Kubota,  Soichiro Kitamura,  Keisuke Takahata,  Chie Seki,  Yuhei Takado,  Hitoshi Shinoto,  Yasunori Sano,  Yasuharu Yamamoto,  Kiwamu Matsuoka,  Hiroyuki Takuwa,  Masafumi Shimojo,  Takahashi Manami,  Kazunori Kawamura,  Tatsuya Kikuchi,  Maki Okada,  Haruhiko Akiyama,  Hisaomi Suzuki,  Mitsumoto Onaya,  Takahiro Takeda,  Kimihito Arai,  Nobutaka Arai,  Nobuyuki Araki,  Yuko Saito,  John Q. Trojanowski,  Virginia M.Y. Lee,  Sushil K. Mishra,  Yoshiki Yamaguchi,  Yasuyuki Kimura,  Masanori Ichise,  Yutaka Tomita,  Ming-Rong Zhang,  Tetsuya Suhara,  Masahiro Shigeta,  Naruhiko Sahara,  Makoto Higuchi,  Hitoshi Shimada Neuron, 1 - 17, 2021, DOI:10.1016/j.neuron.2020.09.042
  18. Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model. Masafumi Shimojo, Hiroyuki Takuwa Yuhei Takado,Masaki Tokunaga,  Satoshi Tsukamoto,  Keiichiro Minatohara,  Maiko Ono,  Chie Seki,  Jun Maeda,  Takuya Urushihata,  Takeharu Minamihisamatsu,  Ichio Aoki,  Kazunori Kawamura,  Ming-Rong Zhang,  Tetsuya Suhara,  Naruhiko Sahara,  Makoto Higuchi Journal of Neuroscience, 3491 - 3501, 2020, DOI:10.1523/JNEUROSCI.2880-19.2020
  19. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys Yuji Nagai,  Naohisa Miyakawa,  Hiroyuki Takuwa,  Yukiko Hori,  Kei Oyama,  Bin Ji,  Takahashi Manami,  Xi-Ping Huang,  Samuel T. Slocum,  Jeffrey F. DiBerto,  Yan Xiong,  Takuya Urushihata,  Toshiyuki Hirabayashi,  Atsushi Fujimoto,  Koki Mimura,  Justin G. English,  Jing Liu,  Ken-ichi Inoue,  Katsushi Kumata,  Chie Seki,  Maiko Ono,  Masafumi Shimojo,  Ming-Rong Zhang,  Yutaka Tomita,  Jin Nakahara ,  Tetsuya Suhara,  Masahiko Takada,  Makoto Higuchi,  Jian Jin,  Bryan L. Roth,  Takafumi Minamimoto Nature Neuroscience, 1157 - 1167, 2020, DOI:10.1038/s41593-020-0661-3
  20. Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells. Takayuki Obata, Jeff Kershaw, Yasuhiko Tachibana, Takayuki Miyauchi, Yoichiro Abe, Sayaka Shibata, Hiroshi Kawaguchi, Yoko Ikoma, Hiroyuki Takuwa, Ichio Aoki, Masato Yasui Scientific reports, 17954, 2018, DOI:10.1038/s41598-018-36264-9
  21. Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with 64Cu-labeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts Yukie Yoshii, Mitsuyoshi Yoshimoto Hiroki Matsumoto Hideaki Tashima Yuma Iwao,  Hiroyuki Takuwa,  Eiji Yoshida,  Hidekatsu Wakizaka,  Taiga Yamaya,  Ming-Rong Zhang,  Aya Sugyo,  Sayaka Hanadate,  Atsushi Tsuji,  Tatsuya Higashi Oncotarget, 28935 - 28950, 2018, DOI:10.18632/oncotarget.25649
  22. Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow. Takuya Urushihata,  Hiroyuki Takuwa,  Chie Seki,  Yasuhiko Tachibana,  Manami Takahashi,  Jeff Kershaw,  Yuhei Takado,  Ichio Aoki,  Makoto Higuchi,  Hiroshi Ito,  Takayuki Obata an official journal of Japan Society of Magnetic Resonance in Medicine, , 318 - 324, 2018, DOI:10.2463/mrms.mp.2017-0149
  23. Imaging of neuronal activity in awake mice by measurements of flavoprotein autofluorescence corrected for cerebral blood flow Takahashi Manami,  Takuya Urushihata,  Hiroyuki Takuwa*,  Kazumi Sakata,  Yuhei Takado,  Eiji Shimizu,  Tetsuya Suhara,  Makoto Higuchi,  Hiroshi Ito Frontiers Neuroscience, 11(723), 2018, DOI:10.3389/fnins.2017.00723
  24. In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510 Ai Ishikawa,  Masaki Tokunaga,  Jun Maeda,  Takeharu Minamihisamatsu,  Masafumi Shimojo,  Hiroyuki Takuwa,  Maiko Ono,  Ruiqing Ni,  Shigeki Hirano ,  Satoshi Kuwabara,  Bin Ji,  Ming-Rong Zhang,  Ichio Aoki,  Tetsuya Suhara,  Makoto Higuchi,  Naruhiko Sahara Journal of Alzheimer's Disease, 1037 - 1052, 2018, DOI:10.3233/JAD-170509
  25. Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia. Iwao Kanno,  Chie Seki,  Hiroyuki Takuwa,  Zhao-Hui Jin,  Didier Boturyn,  Pascal Dumy,  Takako Furukawa,  Tsuneo Saga,  Hiroshi Ito,  Kazuto Masamoto Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia. Journal of cerebral blood flow and metabolism : journal of Cerebral Blood Flow and Metabolism, 687 - 696, 2018, DOI:10.1177/0271678X1668980
  26. In vivo tau imaging for a diagnostic platform of tauopathy using the rTg4510 mouse line Naruhiko Sahara,  Masafumi Shimojo,  Maiko Ono,  Hiroyuki Takuwa,  Febo Marcelo,  Makoto Higuchi,  Tetsuya Suhara Frontiers in Neurology, 8(663), 2017, DOI:10.3389/fneur.2017.00663
  27. Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine  transporters, and dopamine D2 receptors Hiroshi Ito,  Hiroshi Kawaguchi,  Fumitoshi Kodaka,  Hiroyuki Takuwa*,  Yoko Ikoma,  Hitoshi Shimada,  Yasuyuki Kimura,  Chie Seki,  Hitoshi Kubo,  Shiro Ishii,  Harumasa Takano,  Tetsuya Suhara NeuroImage,12 - 17, 2017, DOI:10.1016/j.neuroimage.2017.06.066
  28. Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis Hiroshi Ito, Yoko Ikoma, Chie Seki, Yasuyuki Kimura, Hiroshi Kawaguchi, Hiroyuki Takuwa, Masanori Ichise, Tetsuya Suhara, Iwao Kanno Annals of Nuclear Medicine, 273 - 282, 2017, DOI:10.1007/s12149-017-1155-6
  29. Development of a Simultaneous Optical / PET Imaging System for Awake Hiroyuki Takuwa*, Yoko Ikoma,  Eiji Yoshida,  Hideaki Tashima,  Hidekatsu Wakizaka,  Tetsuya Shinaji,  Taiga Yamaya Physics in Medicine and Biology, 6430 - 6440, 2016, DOI:10.1088/0031-9155/61/17/6430
  30. Food Search Strategy Changes in Caenorhabditis elegans under Chronic Starvation Conditions. Takuya Urushihata, Hiroyuki Takuwa*, Asuka Nishino, Aki Kikuchi, Akiyoshi Ichijo, Chie Obara, Tokumitsu Wakabayashi, Kazumi Sakata, Tetsuya Matsuura Journal of experimental zoology. Part A, Ecological genetics and physiology, 409 - 414, 2016, DOI:10.1002/jez.2025
  31. Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope. Hiroshi Ito Hiroyuki Takuwa*,  Yosuke Tajima,  Hiroshi Kawaguchi,  Takuya Urushihata,  Junko Taniguchi,  Yoko Ikoma,  Chie Seki,  Masanobu Ibaraki,  Kazuto Masamoto,  Iwao Kanno The journal of physiological sciences : JPS, 325 - 330, 2017, DOI:10.1007/s12576-016-0466-z
  32. Inhibitory effects of caffeine on gustatory plasticity in the nematode Caenorhabditis elegans. Takuya Urushihata,  Hiroyuki Takuwa*,  Yukako Higuchi,  Kazumi Sakata,  Tokumitsu Wakabayashi,  Asuka Nishino,  Tetsuya Matsuura Bioscience, biotechnology, and biochemistry, 1990 - 1994, 2016, DOI:10.1080/09168451.2016.1191327
  33. Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model. Asuka Nishino, Yosuke Tajima  Hiroyuki Takuwa*,  Kazuto Masamoto,  Junko Taniguchi,  Hidekatsu Wakizaka,  Daisuke Kokuryo,  Takuya Urushihata,  Ichio Aoki,  Iwao Kanno,  Yutaka Tomita,  Norihiro Suzuki,  Yoko Ikoma,  Hiroshi Ito Scientific Reports, 25072-1 - 25072-8, 2016, DOI:10.1038/srep25072
  34. Dynamic flow velocity mapping from fluorescent dye transit times in the brain surface microcirculation of anesthetized rats and mice. Ryo Hoshikawa,  Hiroshi Kawaguchi,  Hiroyuki Takuwa,  Yoko Ikoma,  Yutaka Tomita,  Miyuki Unekawa,  Norihiro Suzuki,  Iwao Kanno,  Kazuto Masamoto Microcirculation (New York, N.Y. : 1994), 416 - 425, 2016, DOI:10.1111/micc.12285
  35. Washout rate in rat brain irradiated by a (11)C beam after acetazolamide loading using a small single-ring OpenPET prototype. Yoshiyuki Hirano  Hiroyuki Takuwa,  Eiji Yoshida,  Fumihiko Nishikido,  Yasunori Nakajima,  Hidekatsu Wakizaka,  Taiga Yamaya Physics in medicine and biology, 1875 - 1887, 2016, DOI:10.1088/0031-9155/61/5/1875
  36. Establishment and evaluation of a new highly metastatic tumor cell line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent protein. Hitomi Sudo, Atsushi B Tsuji, Aya Sugyo, Hiroyuki Takuwa, Kazuto Masamoto Yutaka Tomita,Norihiro Suzuki,  Takeshi Imamura,  Mitsuru Koizumi,  Tsuneo Saga International journal of oncology, 525 - 532, 2016, DOI:10.3892/ijo.2015.3300
  37. Vasodilation mechanism of cerebral microvessels induced by neural activation under high baseline CBF level results from hypercapnia in awake mice Asuka Nishino,  Hiroyuki Takuwa*,  Takuya Urushihata,  Hiroshi Ito,  Yoko Ikoma,  Tetsuya Matsuura Microcirculation, 744 - 752, 2016, DOI:doi:10.1111/micc.12250
  38. [(11) C]Raclopride binding in the striatum of minimally restrained and free-walking awake mice in a positron emission tomography study. Hiroyuki Takuwa*, Jun Maeda,  Yoko Ikoma,  Masaki Tokunaga,  Hidekatsu Wakizaka,  Shouko Uchida,  Iwao Kanno,  Junko Taniguchi,  Hiroshi Ito,  Makoto Higuchi Synapse (New York, N.Y.), 600 - 606, 2015, DOI:10.1002/syn.21864
  39. Sensitive Period for the Recovery of the Response Rate of the Wind-Evoked Escape Behavior of Unilaterally Cercus-Ablated Crickets (Gryllus bimaculatus). Hiroyuki Takuwa*, Masamichi Kanou Zoological science, 119 - 123, 2015
  40. Development of new optical imaging systems of oxygen metabolism and simultaneous measurement in hemodynamic changes using awake mice. Hiroyuki Takuwa, Tetsuya Matsuura, Asuka Nishino, Kazumi Sakata, Yosuke Tajima, Hiroshi Ito Journal of neuroscience methods, 9 - 15, 2014, DOI:10.1016/j.jneumeth.2014.08.022
  41. Pial arteries respond earlier than penetrating arterioles to neural activation in the somatosensory cortex in awake mice exposed to chronic hypoxia: an additional mechanism to proximal integration signaling? Yuta Sekiguchi,  Hiroyuki Takuwa,  Hiroshi Kawaguchi,  Takahiro Kikuchi,  Eiji Okada,  Iwao Kanno,  Hiroshi Ito,  Yutaka Tomita,  Yoshiaki Itoh,  Norihiro Suzuki,  Ryo Sudo,  Kazuo Tanishita,  Kazuto Masamoto Journal of cerebral blood flow and metabolism, 1761 - 1770, 2014, DOI:10.1038/jcbfm.2014.140
  42. Changes in cortical microvasculature during misery perfusion measured by two-photon laser scanning microscopy. Yosuke Tajima, Hiroyuki Takuwa, Daisuke Kokuryo, Hiroshi Kawaguchi, Chie Seki, Kazuto Masamoto, Yoko Ikoma, Junko Taniguchi, Ichio Aoki, Yutaka Tomita, Norihiro Suzuki, Iwao Kanno, Naokatsu Saeki, Hiroshi Ito Journal of cerebral blood flow and metabolism, 1363 - 1372, 2014, DOI:10.1038/jcbfm.2014.91
  43. Effects of visual information on the wind-evoked escape behavior of the cricket, Gryllus bimaculatus Masamichi Kanou,  Akane Matsuyama,  Hiroyuki Takuwa Zoological Science, 559 - 564, 2014, DOI:http://dx.doi.org/10.2108/zs130218
  44. Cerebral hemodynamic response to acute hyperoxia in awake mice. Yosuke Tajima, Hiroyuki Takuwa, Asuka Nishino, Tetsuya Matsuura, Hiroshi Kawaguchi, Yoko Ikoma, Junko Taniguchi, Chie Seki, Kazuto Masamoto, Iwao Kanno, Naokatsu Saeki, Hiroshi Ito Brain research, 155 - 63, 2014, DOI:10.1016/j.brainres.2014.01.053
  45. Automated image analysis for diameters and branching points of cerebral penetrating arteries and veins captured with two-photon microscopy. Takuma Sugashi, Kouichi Yoshihara, Hiroshi Kawaguchi, Hiroyuki Takuwa, Hiroshi Ito, Iwao Kanno, Yukio Yamada, Kazuto Masamoto Advances in experimental medicine and biology, 209 - 215, 2014
  46. Vessel specific imaging of glucose transfer with fluorescent glucose analogue in anesthetized mouse cortex. Rei Murata, Yuki Takada, Hiroyuki Takuwa, Hiroshi Kawaguchi, Hiroshi Ito, Iwao Kanno, Naotomo Tottori, Yukio Yamada, Yutaka Tomita, Yoshiaki Itoh, Norihiro Suzuki, Katsuya Yamada, Kazuto Masamoto Advances in experimental medicine and biology, 241 - 246, 2014
  47. Reproducibility of measuring cerebral blood flow by laser-Doppler flowmetry in mice Yosuke Tajima, Hiroyuki Takuwa, Hiroshi Kawaguchi, Kazuto Masamoto, Yoko Ikoma, Chie Seki, Junko Taniguchi, Iwao Kanno, Naokatsu Saeki, Hiroshi Ito Frontiers in Bioscience Elite Edition, 62 - 68, 2014, DOI:10.2741/E691
  48. Evaluation of Rho-Kinase Activity in Mice Brain Using N-[(11)C]Methyl-hydroxyfasudil with Positron Emission Tomography. Junko Taniguchi, Chie Seki, Hiroyuki Takuwa, Hiroshi Kawaguchi, Yoko Ikoma, Masayuki Fujinaga, Iwao Kanno, Ming-Rong Zhang, Satoshi Kuwabara, Hiroshi Ito Molecular imaging and biology:  MIB : the official publication of the Academy of Molecular Imaging, 395 - 402, 2014, DOI:10.1007/s11307-013-0695-y
  49. Microvascular sprouting, extension, and creation of new capillary connections with adaptation of the neighboring astrocytes in adult muose cortex under chronic hypoxia Kazuto Masamoto, Hiroyuki Takuwa, Chie Seki, Junko Taniguchi, Yoshiaki Itoh, Yutaka Tomita, Haruki Toriumi, Miyuki Unekawa, Hiroshi Kawaguchi, Hiroshi Ito, Norihiro Suzuki, Iwao Kanno Journal of Cerebral Blood Flow & Metabolism, 325 - 331, 2014, DOI:10.1038/jcbfm.2013.201
  50. Hemodynamic changes during neural deactivation in awake mice: A measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis Hiroyuki Takuwa, Yousuke Tajima, Daisuke Kokuryo, Tetsuya Matsuura, Hiroshi Kawaguchi, Kazuto Masamoto, Jyunko Taniguchi, Yoko Ikoma, Chie Seki, Ichio Aoki, Yutaka Tomita, Norihiro Suzuki, Iwao Kanno, Hiroshi Ito Brain Research, 350 - 355, 2013
  51. Measuring the vascular diameter of brain surface and parenchymal arteries in awake mouse. Yuta Sekiguchi, Kazuto Masamoto, Hiroyuki Takuwa, Hiroshi Kawaguchi, Iwao Kanno, Hiroshi Ito, Yutaka Tomita, Yoshiaki Itoh, Norihiro Suzuki, Ryo Sudo, Kazuo Tanishita Advances in Experimental Medicine and Biology ; v.789, 419 - 425, 2013
  52. Layer-specific dilation of penetrating arteries induced by stimulation of the nucleus basalis of Meynert in the mouse frontal cortex Harumi Hotta, Kazuto Masamoto, Sae Uchida, Yuta Sekiguchi, Hiroyuki Takuwa, Hiroshi Kawaguchi, Ryo Sudo, Kazuo Tanishita, Hiroshi Ito, Iwao Kanno, et.al Journal of Cerebral Blood Flow and Metabolism, 1440 - 1447, 2013, DOI:10.1038/jcbfm.2013.92
  53. Hypoxia-Induced Cerebral Angiogenesis in Mouse Cortex with Two-Photon MicroscopyKazuto Masamoto, Hiroyuki Takuwa, Yutaka Tomita, Haruki Toriumi, Miyuki Unekawa, Jyunko Taniguchi, Hiroshi Kawaguchi, Yoshiaki Itoh, Norihiro Suzuki, Hiroshi Ito, Iwao Kanno Advances in Experimental Medicine and Biology ; v.789, 15 - 20, 2013
  54. Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice Jun-Ichiro Shimada, Jyunko Taniguchi, Masahiro Mori, Yasunori Sato, Hiroyuki Takuwa, Hiroshi Ito, Satoshi Kuwabara Experimental Neurology, 182 - 187, 2013
  55. Long-term adaptation of cerebral hemodynamic response to somatosensory stimulation during chronic hypoxia in awake mice Hiroyuki Takuwa, Kazuto Masamoto, Kyoko Yamazaki, Hiroshi Kawaguchi, Yoko Ikoma, Yousuke Tajima, Takayuki Obata, Iwao Kanno, Hiroshi Ito, Journal of Cerebral Blood Flow and Metabolism, 774 - 779, 2013, DOI:10.1038/jcbfm.2013.16
  56. Effects of the delay and duration of self-generated wind on behavioral compensation in unilaterally cercus-ablated crickets, Gryllus bimaculatus Hiroyuki Takuwa, Masamich Kanou, Zoological Science, 339 - 344, 2013
  57. 3D analysis of intracortical microvasculature during chronic hypoxia in mouse brains Kouichi Yoshihara, Hiroyuki Takuwa, Iwao Kanno, Yukio Yamada, Kazuto Masamoto, et.al Advances in Experimental Medicine and Biology ; v. 765, 357 - 363, 2012
  58. Repeated longitudinal in vivo imaging of neuro-glio-vascular unit at the peripheral boundary of ischemia in mouse cerebral cortex Kazuto Masamoto, Yutaka Tomita, Haruki Toriumi, Ichio Aoki, Miyuki Unekawa, Hiroyuki Takuwa, Yoshiaki Itoh, Norihiro Suzuki, Iwao Kanno Neuroscience, 212, 190 - 200, 2012
  59. Hemodynamic changes during somatosensory stimulation in awake and isoflurane-anesthetized mice measured by laser-Doppler flowmetry Hiroyuki Takuwa, Tetsuya Matsuura, Takayuki Obata, Hiroshi Kawaguchi, Iwao Kanno, Hiroshi Ito, 1472, 107 - 112, 2012
  60. Reproducibility and Variance of a Stimulation-Induced Hemodynamic Response in Barrel Cortex of Awake Behaving Mice Hiroyuki Takuwa, Autio Joonas, Haruka Nakayama, Tetsuya Matsuura, Takayuki Obata, Eiji Okada, Kazuto Masamoto, Iwao Kanno Brain Research, 1369, 103 - 111, 2011, DOI:10.1016/j.brainres.2010.11.007
  61. Contribution of nitric oxide to cerebral blood flow regulation under hypoxia in rats. Hiroyuki Takuwa, Tetsuya Matsuura, Rumiana Bakalova-Zheleva, Takayuki Obata, Iwao Kanno The Journal of Physiological Sciences, 60(6), 399 - 406, 2010, DOI:10.1007/s12576-010-0108-9
  62. Effect of cyclooxygenase-2 on the regulation of cerebral blood flow during neuronal activation in the rat. Tetsuya Matsuura, Hiroyuki Takuwa, Rumiana Bakalova-Zheleva, Takayuki Obata, Iwao Kanno Neuroscience Research, 65(1), 64 - 70, 2009, DOI:10.1016/j.neures.2009.05.006
  63. Rearing under different conditions results in different functional recoveries of giant interneurons in unilaterally cercus-ablated crickets, Gryllus bimaculatus. Masamich Kanou, Hiroyuki Takuwa Zoological Science, 25(6), 653 - 661, 2008
  64. Rearing under different conditions results in different functional recoveries of giant interneurons in unilaterally cercus-ablated crickets, Gryllus bimaculatus. Hiroyuki Kuroishi, Hiroyuki Takuwa, Masamich Kanou Zoological Science, 25(3), 235 - 241, 2008
  65. Effects of self-generated wind on compensational recovery of escape direction in unilaterally cercus-ablated crickets, Gryllus bimaculatus. Hiroyuki Takuwa, Ota Shinji, Masamich Kanoul Zoological Science, 25(3), 235 - 241, 2008
  66. Sensitive period in which walking affects recovery of direction of wind-evoked escape in cricket. Hiroyuki Takuwa, Masamich Kanoul Zoological Science, 24, 331 - 3371, 2007

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